FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891035315> ?p ?o ?g. }

• W2891035315 endingPage "1955" @default.
• W2891035315 startingPage "1948" @default.
• W2891035315 abstract "OBJECTIVES To determine whether antidepressant use is associated with dementia risk. DESIGN Prospective cohort study. SETTING Kaiser Permanente Washington (KPWA), an integrated healthcare delivery system. PARTICIPANTS Community‐dwelling individuals aged 65 and older without dementia and with 10 years or more of KPWA enrollment at baseline (N=3,059). MEASUREMENTS Primary exposures were selective serotonin reuptake inhibitors (paroxetine vs other), tricyclic antidepressants, and serotonin antagonist and reuptake inhibitors. Using health plan pharmacy data, we calculated cumulative medication exposure, defined as total standardized daily doses (TSDDs), over rolling 10‐year windows. Exposure in the most recent year was excluded to avoid use related to prodromal symptoms. The Cognitive Abilities Screening Instrument was administered every 2 years; low scores triggered clinical evaluation and consensus diagnosis procedures. Dementia risk was estimated according to medication use using Cox proportional hazards models. RESULTS During a mean follow‐up of 7.7 years, 775 participants (25%) developed dementia; 659 (22%) developed possible or probable Alzheimer's disease. Individual antidepressant classes were not associated with differences in dementia risk, although paroxetine use was associated with higher risk of dementia for all TSDD categories than no use (0–90 TSDDs: hazard ratio (HR)=1.69, 95% confidence interval (CI)=1.18–2.42; 91–365 TSDDs: HR=1.40, 95% CI=0.88–2.23; 366–1095 TSDDs: HR=2.13, 95% CI=1.32–3.43; ≥1095 TSDDs: HR=1.42, 95% CI=0.82–2.46). CONCLUSION Most commonly prescribed nonanticholinergic depression medications used in late life do not appear to be associated with dementia risk. Paroxetine and other anticholinergic antidepressants may be exceptions in older individuals. Future studies are warranted to improve scientific understanding of potential associations in other settings and populations." @default.
• W2891035315 created "2018-09-27" @default.
• W2891035315 creator A5010801722 @default.
• W2891035315 creator A5012859357 @default.
• W2891035315 creator A5016213068 @default.
• W2891035315 creator A5022790378 @default.
• W2891035315 creator A5035154676 @default.
• W2891035315 creator A5050170858 @default.
• W2891035315 creator A5069885394 @default.
• W2891035315 creator A5073761403 @default.
• W2891035315 date "2018-09-17" @default.
• W2891035315 modified "2023-09-25" @default.
• W2891035315 title "Cumulative Antidepressant Use and Risk of Dementia in a Prospective Cohort Study" @default.
• W2891035315 cites W1506063558 @default.
• W2891035315 cites W1968551454 @default.
• W2891035315 cites W1969375208 @default.
• W2891035315 cites W1986777050 @default.
• W2891035315 cites W1987604172 @default.
• W2891035315 cites W2002371642 @default.
• W2891035315 cites W2005982631 @default.
• W2891035315 cites W2015172698 @default.
• W2891035315 cites W2024012851 @default.
• W2891035315 cites W2034460449 @default.
• W2891035315 cites W2044651963 @default.
• W2891035315 cites W2045872917 @default.
• W2891035315 cites W2072983755 @default.
• W2891035315 cites W2076143792 @default.
• W2891035315 cites W2082270426 @default.
• W2891035315 cites W2085892085 @default.
• W2891035315 cites W2089142670 @default.
• W2891035315 cites W2092129469 @default.
• W2891035315 cites W2096513004 @default.
• W2891035315 cites W2116698967 @default.
• W2891035315 cites W2136264604 @default.
• W2891035315 cites W2138680402 @default.
• W2891035315 cites W2140009431 @default.
• W2891035315 cites W2154569902 @default.
• W2891035315 cites W2156220037 @default.
• W2891035315 cites W2168499550 @default.
• W2891035315 cites W2260796177 @default.
• W2891035315 cites W2306793661 @default.
• W2891035315 cites W2323745265 @default.
• W2891035315 cites W2341378930 @default.
• W2891035315 cites W2547934802 @default.
• W2891035315 cites W2559732081 @default.
• W2891035315 cites W2561565201 @default.
• W2891035315 cites W2605242528 @default.
• W2891035315 cites W2605803966 @default.
• W2891035315 cites W2618335481 @default.
• W2891035315 cites W2800521692 @default.
• W2891035315 cites W2801236946 @default.
• W2891035315 cites W4206611663 @default.
• W2891035315 cites W4294185218 @default.
• W2891035315 doi "https://doi.org/10.1111/jgs.15508" @default.
• W2891035315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221747" @default.
• W2891035315 hasPublicationYear "2018" @default.
• W2891035315 type Work @default.
• W2891035315 sameAs 2891035315 @default.
• W2891035315 citedByCount "25" @default.
• W2891035315 countsByYear W28910353152019 @default.
• W2891035315 countsByYear W28910353152020 @default.
• W2891035315 countsByYear W28910353152021 @default.
• W2891035315 countsByYear W28910353152022 @default.
• W2891035315 countsByYear W28910353152023 @default.
• W2891035315 crossrefType "journal-article" @default.
• W2891035315 hasAuthorship W2891035315A5010801722 @default.
• W2891035315 hasAuthorship W2891035315A5012859357 @default.
• W2891035315 hasAuthorship W2891035315A5016213068 @default.
• W2891035315 hasAuthorship W2891035315A5022790378 @default.
• W2891035315 hasAuthorship W2891035315A5035154676 @default.
• W2891035315 hasAuthorship W2891035315A5050170858 @default.
• W2891035315 hasAuthorship W2891035315A5069885394 @default.
• W2891035315 hasAuthorship W2891035315A5073761403 @default.
• W2891035315 hasConcept C118552586 @default.
• W2891035315 hasConcept C126322002 @default.
• W2891035315 hasConcept C139719470 @default.
• W2891035315 hasConcept C162324750 @default.
• W2891035315 hasConcept C188816634 @default.
• W2891035315 hasConcept C201903717 @default.
• W2891035315 hasConcept C207103383 @default.
• W2891035315 hasConcept C2776867660 @default.
• W2891035315 hasConcept C2777828372 @default.
• W2891035315 hasConcept C2779134260 @default.
• W2891035315 hasConcept C2779177272 @default.
• W2891035315 hasConcept C2779483572 @default.
• W2891035315 hasConcept C2780092697 @default.
• W2891035315 hasConcept C2781161787 @default.
• W2891035315 hasConcept C44249647 @default.
• W2891035315 hasConcept C50382708 @default.
• W2891035315 hasConcept C71924100 @default.
• W2891035315 hasConcept C72563966 @default.
• W2891035315 hasConcept C88879693 @default.
• W2891035315 hasConceptScore W2891035315C118552586 @default.
• W2891035315 hasConceptScore W2891035315C126322002 @default.
• W2891035315 hasConceptScore W2891035315C139719470 @default.
• W2891035315 hasConceptScore W2891035315C162324750 @default.
• W2891035315 hasConceptScore W2891035315C188816634 @default.
• W2891035315 hasConceptScore W2891035315C201903717 @default.

• next