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- W2891036643 abstract "Summary To better understand the mechanisms of bacterial adaptation in oxygen environments, we explored the aerobic living‐associated genes in bacteria by comparing Clusters of Orthologous Groups of proteins’ (COGs) frequencies and gene expression analyses and 38 COGs were detected at significantly higher frequencies ( p ‐value less than 1e−6) in aerobes than in anaerobes. Differential expression analyses between two conditions further narrowed the prediction to 27 aerobe‐specific COGs. Then, we annotated the enzymes associated with these COGs. Literature review revealed that 14 COGs contained enzymes catalysing oxygen‐involved reactions or products involved in aerobic pathways, suggesting their important roles for survival in aerobic environments. Additionally, protein–protein interaction analyses and step length comparisons of metabolic networks suggested that the other 13 COGs may function relevantly with the 14 enzymes‐corresponding COGs, indicating that these genes may be highly associated with oxygen utilization. Phylogenetic and evolutionary analyses showed that the 27 COGs did not have similar trees, and all suffered purifying selection pressures. The divergent times of species containing or lacking aerobic COGs validated that the appearing time of oxygen‐utilizing gene was approximately 2.80 Gyr ago. In addition to help better understand oxygen adaption, our method may be extended to identify genes relevant to other living environments." @default.
- W2891036643 created "2018-09-27" @default.
- W2891036643 creator A5032443397 @default.
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- W2891036643 date "2018-10-01" @default.
- W2891036643 modified "2023-09-26" @default.
- W2891036643 title "Comprehensive exploration of the enzymes catalysing oxygen-involved reactions and COGs relevant to bacterial oxygen utilization" @default.
- W2891036643 cites W1037240140 @default.
- W2891036643 cites W1270834676 @default.
- W2891036643 cites W1550566612 @default.
- W2891036643 cites W1564233804 @default.
- W2891036643 cites W1565252999 @default.
- W2891036643 cites W1606892626 @default.
- W2891036643 cites W1651947609 @default.
- W2891036643 cites W1658174274 @default.
- W2891036643 cites W1826970303 @default.
- W2891036643 cites W1966749659 @default.
- W2891036643 cites W1969989079 @default.
- W2891036643 cites W1971166054 @default.
- W2891036643 cites W1974828111 @default.
- W2891036643 cites W1979579160 @default.
- W2891036643 cites W1983526625 @default.
- W2891036643 cites W1989765404 @default.
- W2891036643 cites W1990453950 @default.
- W2891036643 cites W1991915828 @default.
- W2891036643 cites W1993476352 @default.
- W2891036643 cites W2026205682 @default.
- W2891036643 cites W2033334698 @default.
- W2891036643 cites W2036681907 @default.
- W2891036643 cites W2042529592 @default.
- W2891036643 cites W2043244351 @default.
- W2891036643 cites W2045641994 @default.
- W2891036643 cites W2047510552 @default.
- W2891036643 cites W2053996331 @default.
- W2891036643 cites W2055043387 @default.
- W2891036643 cites W2056511259 @default.
- W2891036643 cites W2065903286 @default.
- W2891036643 cites W2069511429 @default.
- W2891036643 cites W2070939819 @default.
- W2891036643 cites W2079525244 @default.
- W2891036643 cites W2080001360 @default.
- W2891036643 cites W2081304299 @default.
- W2891036643 cites W2081383679 @default.
- W2891036643 cites W2091115575 @default.
- W2891036643 cites W2094514994 @default.
- W2891036643 cites W2095753590 @default.
- W2891036643 cites W2103148772 @default.
- W2891036643 cites W2104749114 @default.
- W2891036643 cites W2108487003 @default.
- W2891036643 cites W2108639691 @default.
- W2891036643 cites W2110335151 @default.
- W2891036643 cites W2117260150 @default.
- W2891036643 cites W2117913657 @default.
- W2891036643 cites W2118088024 @default.
- W2891036643 cites W2120875291 @default.
- W2891036643 cites W2131635947 @default.
- W2891036643 cites W2136632285 @default.
- W2891036643 cites W2137015675 @default.
- W2891036643 cites W2145450659 @default.
- W2891036643 cites W2146512944 @default.
- W2891036643 cites W2148231054 @default.
- W2891036643 cites W2148998200 @default.
- W2891036643 cites W2149292210 @default.
- W2891036643 cites W2152207030 @default.
- W2891036643 cites W2154384871 @default.
- W2891036643 cites W2156615630 @default.
- W2891036643 cites W2157668625 @default.
- W2891036643 cites W2162142896 @default.
- W2891036643 cites W2162237022 @default.
- W2891036643 cites W2163291758 @default.
- W2891036643 cites W2168183908 @default.
- W2891036643 cites W2168546553 @default.
- W2891036643 cites W2169929748 @default.
- W2891036643 cites W2178043251 @default.
- W2891036643 cites W2223752691 @default.
- W2891036643 cites W2319077307 @default.
- W2891036643 cites W2336330109 @default.
- W2891036643 cites W2537623931 @default.
- W2891036643 cites W2567496106 @default.
- W2891036643 cites W2576098192 @default.
- W2891036643 cites W2590320639 @default.
- W2891036643 cites W2741072118 @default.
- W2891036643 cites W2765689343 @default.
- W2891036643 cites W2804260305 @default.
- W2891036643 cites W4246755122 @default.
- W2891036643 cites W2321553288 @default.
- W2891036643 doi "https://doi.org/10.1111/1462-2920.14399" @default.
- W2891036643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30187624" @default.
- W2891036643 hasPublicationYear "2018" @default.
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