FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891037544> ?p ?o ?g. }

• W2891037544 endingPage "422" @default.
• W2891037544 startingPage "414" @default.
• W2891037544 abstract "The mode of action (MOA) plays a key role in the risk assessment of pollutants in water. Although fish is a key model organism used in the risk assessment of pollutants in water, the MOAs have not been compared between fish and embryo toxicity for classified compounds. In this paper, regression analysis was carried out for fish and embryo toxicities against the calculated molecular descriptors and MOAs were evaluated from toxicity ratio. The toxicity significantly related with the chemical hydrophobicity for baseline and less inert compounds, respectively, indicates that these two classes of compounds share the same MOAs between fish and embryos. Comparison of the toxicity ratios shows that reactive compounds exhibit excess toxicity to both fish and embryos. These compounds can react covalently with biologically target molecules through nucleophilic addition reactions, Michael addition oxidation, or amination. Comparing with baseline, less inert and reactive compounds, many specifically-acting compounds have strong docking capacity with protein molecules. Some specifically-acting compounds, such as fungicides, have very similar toxic effect to both fish and embryos. However, insecticides are more toxic to fish than embryos; herbicides and medications are more toxic to embryos than fish. Differences in the interactions of chemicals with target molecules or bioconcentration potentials between fish and embryos may result in the differences in toxic effects. There are some factors that influence the identification of MOAs, such as quality of toxicity data, bioavailability and ionization. These factors should be considered in the identification of MOAs in the risk assessment of organic pollutants." @default.
• W2891037544 created "2018-09-27" @default.
• W2891037544 creator A5003753200 @default.
• W2891037544 creator A5005279115 @default.
• W2891037544 creator A5009703036 @default.
• W2891037544 creator A5013291648 @default.
• W2891037544 creator A5033632697 @default.
• W2891037544 creator A5048936273 @default.
• W2891037544 creator A5082268344 @default.
• W2891037544 creator A5088794437 @default.
• W2891037544 date "2018-12-01" @default.
• W2891037544 modified "2023-09-27" @default.
• W2891037544 title "Comparison of modes of action between fish and zebrafish embryo toxicity for baseline, less inert, reactive and specifically-acting compounds" @default.
• W2891037544 cites W1591329553 @default.
• W2891037544 cites W1968138977 @default.
• W2891037544 cites W1968621055 @default.
• W2891037544 cites W1969712562 @default.
• W2891037544 cites W1975650851 @default.
• W2891037544 cites W1975743313 @default.
• W2891037544 cites W1980498387 @default.
• W2891037544 cites W1987901992 @default.
• W2891037544 cites W1993636014 @default.
• W2891037544 cites W2002842896 @default.
• W2891037544 cites W2012536183 @default.
• W2891037544 cites W2018408493 @default.
• W2891037544 cites W2039965406 @default.
• W2891037544 cites W2046975558 @default.
• W2891037544 cites W2047942099 @default.
• W2891037544 cites W2049476219 @default.
• W2891037544 cites W2051190954 @default.
• W2891037544 cites W2066921279 @default.
• W2891037544 cites W2071974614 @default.
• W2891037544 cites W2076147571 @default.
• W2891037544 cites W2083632909 @default.
• W2891037544 cites W2085808198 @default.
• W2891037544 cites W2090497107 @default.
• W2891037544 cites W2092324560 @default.
• W2891037544 cites W2093217911 @default.
• W2891037544 cites W2105712492 @default.
• W2891037544 cites W2107892117 @default.
• W2891037544 cites W2133358624 @default.
• W2891037544 cites W2248075703 @default.
• W2891037544 cites W2295139731 @default.
• W2891037544 cites W2315142590 @default.
• W2891037544 cites W2517184241 @default.
• W2891037544 cites W2588932771 @default.
• W2891037544 cites W2767645080 @default.
• W2891037544 cites W2839351936 @default.
• W2891037544 cites W4249612817 @default.
• W2891037544 cites W4250736707 @default.
• W2891037544 doi "https://doi.org/10.1016/j.chemosphere.2018.09.072" @default.
• W2891037544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243207" @default.
• W2891037544 hasPublicationYear "2018" @default.
• W2891037544 type Work @default.
• W2891037544 sameAs 2891037544 @default.
• W2891037544 citedByCount "6" @default.
• W2891037544 countsByYear W28910375442020 @default.
• W2891037544 countsByYear W28910375442022 @default.
• W2891037544 countsByYear W28910375442023 @default.
• W2891037544 crossrefType "journal-article" @default.
• W2891037544 hasAuthorship W2891037544A5003753200 @default.
• W2891037544 hasAuthorship W2891037544A5005279115 @default.
• W2891037544 hasAuthorship W2891037544A5009703036 @default.
• W2891037544 hasAuthorship W2891037544A5013291648 @default.
• W2891037544 hasAuthorship W2891037544A5033632697 @default.
• W2891037544 hasAuthorship W2891037544A5048936273 @default.
• W2891037544 hasAuthorship W2891037544A5082268344 @default.
• W2891037544 hasAuthorship W2891037544A5088794437 @default.
• W2891037544 hasConcept C104317684 @default.
• W2891037544 hasConcept C107872376 @default.
• W2891037544 hasConcept C116263406 @default.
• W2891037544 hasConcept C178790620 @default.
• W2891037544 hasConcept C185592680 @default.
• W2891037544 hasConcept C196843134 @default.
• W2891037544 hasConcept C2776878037 @default.
• W2891037544 hasConcept C29730261 @default.
• W2891037544 hasConcept C33070731 @default.
• W2891037544 hasConcept C505870484 @default.
• W2891037544 hasConcept C55493867 @default.
• W2891037544 hasConcept C82685317 @default.
• W2891037544 hasConcept C86803240 @default.
• W2891037544 hasConceptScore W2891037544C104317684 @default.
• W2891037544 hasConceptScore W2891037544C107872376 @default.
• W2891037544 hasConceptScore W2891037544C116263406 @default.
• W2891037544 hasConceptScore W2891037544C178790620 @default.
• W2891037544 hasConceptScore W2891037544C185592680 @default.
• W2891037544 hasConceptScore W2891037544C196843134 @default.
• W2891037544 hasConceptScore W2891037544C2776878037 @default.
• W2891037544 hasConceptScore W2891037544C29730261 @default.
• W2891037544 hasConceptScore W2891037544C33070731 @default.
• W2891037544 hasConceptScore W2891037544C505870484 @default.
• W2891037544 hasConceptScore W2891037544C55493867 @default.
• W2891037544 hasConceptScore W2891037544C82685317 @default.
• W2891037544 hasConceptScore W2891037544C86803240 @default.
• W2891037544 hasFunder F4320321001 @default.
• W2891037544 hasLocation W28910375441 @default.
• W2891037544 hasLocation W28910375442 @default.
• W2891037544 hasOpenAccess W2891037544 @default.

• next