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• W2891038139 abstract "The goal of this study was to determine the chronic impact of stroke on the manifestation of Alzheimer's disease (AD) related pathology and behavioral impairments in mice. To accomplish this goal, we used two distinct models. First, we experimentally induced ischemic stroke in aged wildtype (wt) C57BL/6 mice to determine if stroke leads to the manifestation of AD-associated pathological β-amyloid (Aβ) and tau in aged versus young adult wt mice. Second, we utilized a transgenic (Tg) mouse model of AD (hAPP-SL) to determine if stroke leads to the worsening of pre-existing AD pathology, as well as the development of pathology in brain regions not typically expressed in AD Tg mice. In the wt mice, there was delayed motor recovery and an accelerated development of cognitive deficits in aged mice compared to young adult mice following stroke. This corresponded with increased brain atrophy, increased cholinergic degeneration, and a focal increase of Aβ in areas of axonal degeneration in the ipsilateral hemisphere of the aged animals. By contrast, in the hAPP-SL mice, we found that ischemia induced aggravated behavioral deficits in conjunction with a global increase in Aβ, tau, and cholinergic pathology compared to hAPP-SL mice that underwent a sham stroke procedure. With regard to a potential mechanism, in both models, we found that the stroke-induced Aβ and tau deposits co-localized with increased levels of β-secretase 1 (BACE1), along with its substrate, neuregulin 1 (NGR1) type III, both of which are proteins integral for myelin repair. Based on these findings, we propose that the chronic sequelae of stroke may be ratcheting-up a myelin repair pathway, and that the consequent increase in BACE1 could be causing an inadvertent cleavage of its alternative substrate, AβPP, resulting in greater Aβ seeding and pathogenesis." @default.
• W2891038139 created "2018-09-27" @default.
• W2891038139 creator A5007509761 @default.
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• W2891038139 creator A5079084859 @default.
• W2891038139 date "2018-09-24" @default.
• W2891038139 modified "2023-10-15" @default.
• W2891038139 title "Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia" @default.
• W2891038139 cites W1504534905 @default.
• W2891038139 cites W1508658753 @default.
• W2891038139 cites W1515977320 @default.
• W2891038139 cites W1520721690 @default.
• W2891038139 cites W1607385122 @default.
• W2891038139 cites W1615217034 @default.
• W2891038139 cites W1644122431 @default.
• W2891038139 cites W1692550889 @default.
• W2891038139 cites W1741002350 @default.
• W2891038139 cites W1743841615 @default.
• W2891038139 cites W1962489230 @default.
• W2891038139 cites W1964117773 @default.
• W2891038139 cites W1966702161 @default.
• W2891038139 cites W1968232509 @default.
• W2891038139 cites W1968419213 @default.
• W2891038139 cites W1978043286 @default.
• W2891038139 cites W1981343019 @default.
• W2891038139 cites W1986344581 @default.
• W2891038139 cites W1987466993 @default.
• W2891038139 cites W1989477751 @default.
• W2891038139 cites W1990632702 @default.
• W2891038139 cites W1996499871 @default.
• W2891038139 cites W1999235115 @default.
• W2891038139 cites W2000045165 @default.
• W2891038139 cites W2001163111 @default.
• W2891038139 cites W2009898502 @default.
• W2891038139 cites W2014186370 @default.
• W2891038139 cites W2034286717 @default.
• W2891038139 cites W2034361661 @default.
• W2891038139 cites W2037426713 @default.
• W2891038139 cites W2041512773 @default.
• W2891038139 cites W2044659008 @default.
• W2891038139 cites W2046627719 @default.
• W2891038139 cites W2052092391 @default.
• W2891038139 cites W2052248444 @default.
• W2891038139 cites W2052466705 @default.
• W2891038139 cites W2055713476 @default.
• W2891038139 cites W2058355219 @default.
• W2891038139 cites W2059547926 @default.
• W2891038139 cites W2060171712 @default.
• W2891038139 cites W2067682988 @default.
• W2891038139 cites W2067727468 @default.
• W2891038139 cites W2075444764 @default.
• W2891038139 cites W2076929722 @default.
• W2891038139 cites W2081868034 @default.
• W2891038139 cites W2082377406 @default.
• W2891038139 cites W2090434536 @default.
• W2891038139 cites W2093374391 @default.
• W2891038139 cites W2093650784 @default.
• W2891038139 cites W2094115917 @default.
• W2891038139 cites W2094785614 @default.
• W2891038139 cites W2095430905 @default.
• W2891038139 cites W2096312363 @default.
• W2891038139 cites W2096766291 @default.
• W2891038139 cites W2101715910 @default.
• W2891038139 cites W2102320098 @default.
• W2891038139 cites W2104227586 @default.
• W2891038139 cites W2107493006 @default.
• W2891038139 cites W2112135302 @default.
• W2891038139 cites W2121469208 @default.
• W2891038139 cites W2121581237 @default.
• W2891038139 cites W2125271940 @default.
• W2891038139 cites W2125985978 @default.
• W2891038139 cites W2126760605 @default.
• W2891038139 cites W2127604118 @default.
• W2891038139 cites W2130418945 @default.
• W2891038139 cites W2130824857 @default.
• W2891038139 cites W2131712664 @default.
• W2891038139 cites W2132194942 @default.
• W2891038139 cites W2134590632 @default.
• W2891038139 cites W2139018071 @default.
• W2891038139 cites W2153140546 @default.
• W2891038139 cites W2157317643 @default.
• W2891038139 cites W2162670203 @default.
• W2891038139 cites W2164878533 @default.
• W2891038139 cites W2165804706 @default.
• W2891038139 cites W2170818431 @default.
• W2891038139 cites W2299145287 @default.
• W2891038139 cites W2299896901 @default.
• W2891038139 cites W2317889588 @default.
• W2891038139 cites W2317915347 @default.
• W2891038139 cites W2402030719 @default.
• W2891038139 cites W2460155242 @default.
• W2891038139 cites W2469466281 @default.
• W2891038139 cites W2510727969 @default.
• W2891038139 cites W2511335713 @default.

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