FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891040066> ?p ?o ?g. }

• W2891040066 endingPage "34915" @default.
• W2891040066 startingPage "34905" @default.
• W2891040066 abstract "Biofilms contribute to persistent bacterial infections as well as formidable resistances to conventional antibiotics. However, it is still a major challenge to establish an advanced antibacterial nanoplatform that can efficiently eradicate biofilms while overcoming bacterial resistances. Taking advantage of the stimuli-responsive technique and the magnetic guidance strategy, here we present a highly efficient nanoplatform for planktonic inactivation and biofilm disruption. The multilayer films consisting of antibiotic gentamicin (Gen), tannic acid, and silver nanoparticles (AgNPs) were fabricated and coated on magnetic nanoparticles via electrostatic interactions. To achieve controlled drug release and improved biocompatibility, biodegradable hyaluronic acid was capped on the outer surface as a responsive shell. In vitro release profiles suggested that the nanocomposites showed both enzyme and pH-responsive release properties. The nanoplatform could be employed as a powerful nanocarrier for small molecular Gen and AgNPs delivery and on-demand release in response to bacterial infection microenvironment. The nanocomposites also showed satisfying antibacterial capacities against planktonic Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Intriguingly, with magnetic field navigation (NdFeB, 2000 gauss), the nanocomposites could be guided to handily penetrate into S. aureus biofilm and performed dual-responsive release, showing significantly enhanced biofilm disruption. Moreover, excess reactive oxygen species production resulting from the nanocomposites contributed to the decomposition of biofilm matrix and ultimate biofilm eradication. As a consequence, the ingenious antibacterial nanoplatform could be promising for combating biofilm infections while overcoming bacterial resistances with extra environmental factors such as magnetic field." @default.
• W2891040066 created "2018-09-27" @default.
• W2891040066 creator A5001195818 @default.
• W2891040066 creator A5005034052 @default.
• W2891040066 creator A5019694374 @default.
• W2891040066 creator A5020014821 @default.
• W2891040066 creator A5022526821 @default.
• W2891040066 creator A5024071206 @default.
• W2891040066 creator A5038510055 @default.
• W2891040066 creator A5042947574 @default.
• W2891040066 creator A5077068949 @default.
• W2891040066 date "2018-09-21" @default.
• W2891040066 modified "2023-10-14" @default.
• W2891040066 title "Microenvironment-Responsive Magnetic Nanocomposites Based on Silver Nanoparticles/Gentamicin for Enhanced Biofilm Disruption by Magnetic Field" @default.
• W2891040066 cites W1832531745 @default.
• W2891040066 cites W1974795936 @default.
• W2891040066 cites W1981224435 @default.
• W2891040066 cites W1997352644 @default.
• W2891040066 cites W2001875667 @default.
• W2891040066 cites W2007331931 @default.
• W2891040066 cites W2008511209 @default.
• W2891040066 cites W2017413302 @default.
• W2891040066 cites W2031518807 @default.
• W2891040066 cites W2032808656 @default.
• W2891040066 cites W2034634701 @default.
• W2891040066 cites W2037966968 @default.
• W2891040066 cites W2038200149 @default.
• W2891040066 cites W2039258127 @default.
• W2891040066 cites W2039832386 @default.
• W2891040066 cites W2044751381 @default.
• W2891040066 cites W2070300719 @default.
• W2891040066 cites W2074598258 @default.
• W2891040066 cites W2076505260 @default.
• W2891040066 cites W2078311490 @default.
• W2891040066 cites W2080936059 @default.
• W2891040066 cites W2089244161 @default.
• W2891040066 cites W2094428846 @default.
• W2891040066 cites W2096007043 @default.
• W2891040066 cites W2099018092 @default.
• W2891040066 cites W2105173502 @default.
• W2891040066 cites W2105403316 @default.
• W2891040066 cites W2113744963 @default.
• W2891040066 cites W2122115838 @default.
• W2891040066 cites W2122836009 @default.
• W2891040066 cites W2125399207 @default.
• W2891040066 cites W2125603952 @default.
• W2891040066 cites W2144440398 @default.
• W2891040066 cites W2145789959 @default.
• W2891040066 cites W2162994037 @default.
• W2891040066 cites W2169313488 @default.
• W2891040066 cites W2205651952 @default.
• W2891040066 cites W2309290067 @default.
• W2891040066 cites W2316592839 @default.
• W2891040066 cites W2324018042 @default.
• W2891040066 cites W2342005825 @default.
• W2891040066 cites W2353656468 @default.
• W2891040066 cites W2415505959 @default.
• W2891040066 cites W2416839921 @default.
• W2891040066 cites W2468052411 @default.
• W2891040066 cites W2508969842 @default.
• W2891040066 cites W2524708063 @default.
• W2891040066 cites W2527952809 @default.
• W2891040066 cites W2561721367 @default.
• W2891040066 cites W2580336020 @default.
• W2891040066 cites W2598995550 @default.
• W2891040066 cites W2619438879 @default.
• W2891040066 cites W271497590 @default.
• W2891040066 cites W2769212526 @default.
• W2891040066 cites W2784428636 @default.
• W2891040066 cites W2795229641 @default.
• W2891040066 doi "https://doi.org/10.1021/acsami.8b10972" @default.
• W2891040066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240195" @default.
• W2891040066 hasPublicationYear "2018" @default.
• W2891040066 type Work @default.
• W2891040066 sameAs 2891040066 @default.
• W2891040066 citedByCount "63" @default.
• W2891040066 countsByYear W28910400662019 @default.
• W2891040066 countsByYear W28910400662020 @default.
• W2891040066 countsByYear W28910400662021 @default.
• W2891040066 countsByYear W28910400662022 @default.
• W2891040066 countsByYear W28910400662023 @default.
• W2891040066 crossrefType "journal-article" @default.
• W2891040066 hasAuthorship W2891040066A5001195818 @default.
• W2891040066 hasAuthorship W2891040066A5005034052 @default.
• W2891040066 hasAuthorship W2891040066A5019694374 @default.
• W2891040066 hasAuthorship W2891040066A5020014821 @default.
• W2891040066 hasAuthorship W2891040066A5022526821 @default.
• W2891040066 hasAuthorship W2891040066A5024071206 @default.
• W2891040066 hasAuthorship W2891040066A5038510055 @default.
• W2891040066 hasAuthorship W2891040066A5042947574 @default.
• W2891040066 hasAuthorship W2891040066A5077068949 @default.
• W2891040066 hasConcept C12554922 @default.
• W2891040066 hasConcept C155672457 @default.
• W2891040066 hasConcept C171250308 @default.
• W2891040066 hasConcept C18150654 @default.
• W2891040066 hasConcept C191897082 @default.
• W2891040066 hasConcept C192562407 @default.
• W2891040066 hasConcept C2777230088 @default.

• next