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• W2891040609 abstract "Further chemical examination of a coral-associated fungus Aspergillus versicolor LZD-14-1 by the PHLC-DAD detection resulted in the isolation of six new polycyclic alkaloids, namely versiquinazolines L-Q (1-6). Their structures were determined by extensive analyses of spectroscopic data, including quantum ECD calculation and X-ray single crystal diffraction for the assignment of absolute configurations. Versiquinazoline L bearing a d-Ala residue and versiquinazoline M containing an l-serine residue are rarely found in the fumiquinazoline-type alkaloids, while versiquinazoline P displayed an unusual scaffold with a spiro-γ-lactone. Versiquinazolines P and Q exhibited significant inhibition against thioredoxin reductase (TrxR) with IC50 values of 13.6 ± 0.6 and 12.2 ± 0.7 μM, which showed higher activity than the positive control curcumin (IC50 = 25 μM). The weak cytotoxicity and potent inhibition toward TrxR suggested that versiquinazolines P and Q are potential for microenvironmental regulation of tumor progression and metastasis." @default.
• W2891040609 created "2018-09-27" @default.
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• W2891040609 date "2018-01-01" @default.
• W2891040609 modified "2023-10-13" @default.
• W2891040609 title "Versiquinazolines L–Q, new polycyclic alkaloids from the marine-derived fungus <i>Aspergillus versicolor</i>" @default.
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• W2891040609 doi "https://doi.org/10.1039/c8ra06854b" @default.
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