FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891042090> ?p ?o ?g. }

• W2891042090 endingPage "4680" @default.
• W2891042090 startingPage "4665" @default.
• W2891042090 abstract "Key points The female hormone oestrogen may protect muscle from injury by reducing inflammation but this is debatable. In this study, the inflammatory response of injured muscle from oestrogen‐replete mice was comprehensively compared to that from oestrogen‐deficient mice. We show that oestrogen markedly promotes movement of neutrophils, an inflammatory white blood cell type, into muscle over the first few days after injury but has only a minor effect on the movement of macrophages, another inflammatory cell type. Despite the enhancement of inflammation by oestrogen in injured muscle, we found strength in oestrogen‐replete mice to recover faster and to a greater extent than it does in oestrogen‐deficient mice. Our study and others indicate that lower doses of oestrogen, such as that used in our study, may affect muscle inflammation and injury differently from higher doses. Abstract Oestrogen has been shown to protect against skeletal muscle injury and a reduced inflammatory response has been suggested as a possible protective mechanism. There are, however, dissenting reports. Our objective was to conduct an unbiased, comprehensive study of the effect of oestradiol on the inflammatory response following muscle injury. Female C57BL6/J mice were ovariectomized and supplemented with and without oestradiol. Tibialis anterior muscles were freeze injured and studied primarily at 1–4 days post‐injury. Oestradiol supplementation increased injured muscle gene expression of neutrophil chemoattractants ( Cxcl1 and Cxcl5 ) and to a lesser extent that of monocyte/macrophage chemoattractants ( Ccl2 and Spp1 ). Oestradiol markedly increased gene expression of the neutrophil cell surface marker ( Ly6g ) but had less consistent effects on the monocyte/macrophage cell surface markers ( Cd68 , Cd163 and Cd206 ). These results were confirmed at the protein level by immunoblot with oestradiol increasing LY6G/C content and having no significant effect on CD163 content. These findings were confirmed with fluorescence‐activated cell sorting counts of neutrophils and macrophages in injured muscles; oestradiol increased the proportion of CD45 + cells that were neutrophils (LY6G + ) but not the proportion that were macrophages (CD68 + or CD206 + ). Physiological impact of the oestradiol‐enhanced neutrophil response was assessed by strength measurements. There was no significant difference in strength between oestradiol‐supplemented and ‐unsupplemented mice until 2 weeks post‐injury; strength was 13–24% greater in supplemented mice at 2–6 weeks post‐injury. In conclusion, a moderate level of oestradiol supplementation enhances neutrophil infiltration in injured muscle and this is associated with a beneficial effect on strength recovery." @default.
• W2891042090 created "2018-09-27" @default.
• W2891042090 creator A5021803788 @default.
• W2891042090 creator A5029843883 @default.
• W2891042090 creator A5033848476 @default.
• W2891042090 creator A5041716623 @default.
• W2891042090 creator A5042196872 @default.
• W2891042090 creator A5058149977 @default.
• W2891042090 creator A5080250954 @default.
• W2891042090 creator A5086929851 @default.
• W2891042090 date "2018-08-24" @default.
• W2891042090 modified "2023-10-18" @default.
• W2891042090 title "A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated" @default.
• W2891042090 cites W1766236253 @default.
• W2891042090 cites W1829471102 @default.
• W2891042090 cites W1840622518 @default.
• W2891042090 cites W1894449564 @default.
• W2891042090 cites W1966338375 @default.
• W2891042090 cites W1973416055 @default.
• W2891042090 cites W1979209500 @default.
• W2891042090 cites W1983047478 @default.
• W2891042090 cites W1987499470 @default.
• W2891042090 cites W1994272750 @default.
• W2891042090 cites W1997766067 @default.
• W2891042090 cites W1999353686 @default.
• W2891042090 cites W1999417131 @default.
• W2891042090 cites W1999837506 @default.
• W2891042090 cites W2004726232 @default.
• W2891042090 cites W2015471032 @default.
• W2891042090 cites W2019431332 @default.
• W2891042090 cites W2028194205 @default.
• W2891042090 cites W2037716289 @default.
• W2891042090 cites W2039686723 @default.
• W2891042090 cites W2040201653 @default.
• W2891042090 cites W2050516070 @default.
• W2891042090 cites W2065487494 @default.
• W2891042090 cites W2068066679 @default.
• W2891042090 cites W2068382500 @default.
• W2891042090 cites W2068515330 @default.
• W2891042090 cites W2071065778 @default.
• W2891042090 cites W2072475154 @default.
• W2891042090 cites W2081090696 @default.
• W2891042090 cites W2083047168 @default.
• W2891042090 cites W2083315142 @default.
• W2891042090 cites W2088148916 @default.
• W2891042090 cites W2088755431 @default.
• W2891042090 cites W2099249565 @default.
• W2891042090 cites W2101116633 @default.
• W2891042090 cites W2106835200 @default.
• W2891042090 cites W2106994385 @default.
• W2891042090 cites W2112876140 @default.
• W2891042090 cites W2116809283 @default.
• W2891042090 cites W2119032894 @default.
• W2891042090 cites W2119434539 @default.
• W2891042090 cites W2120038817 @default.
• W2891042090 cites W2121373623 @default.
• W2891042090 cites W2142379278 @default.
• W2891042090 cites W2143082806 @default.
• W2891042090 cites W2157129857 @default.
• W2891042090 cites W2159203244 @default.
• W2891042090 cites W2166196669 @default.
• W2891042090 cites W2168806734 @default.
• W2891042090 cites W2263931661 @default.
• W2891042090 cites W2269278230 @default.
• W2891042090 cites W2338484349 @default.
• W2891042090 cites W2508233170 @default.
• W2891042090 cites W2766307829 @default.
• W2891042090 cites W59013584 @default.
• W2891042090 doi "https://doi.org/10.1113/jp276432" @default.
• W2891042090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166067" @default.
• W2891042090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30035314" @default.
• W2891042090 hasPublicationYear "2018" @default.
• W2891042090 type Work @default.
• W2891042090 sameAs 2891042090 @default.
• W2891042090 citedByCount "27" @default.
• W2891042090 countsByYear W28910420902018 @default.
• W2891042090 countsByYear W28910420902019 @default.
• W2891042090 countsByYear W28910420902020 @default.
• W2891042090 countsByYear W28910420902021 @default.
• W2891042090 countsByYear W28910420902022 @default.
• W2891042090 countsByYear W28910420902023 @default.
• W2891042090 crossrefType "journal-article" @default.
• W2891042090 hasAuthorship W2891042090A5021803788 @default.
• W2891042090 hasAuthorship W2891042090A5029843883 @default.
• W2891042090 hasAuthorship W2891042090A5033848476 @default.
• W2891042090 hasAuthorship W2891042090A5041716623 @default.
• W2891042090 hasAuthorship W2891042090A5042196872 @default.
• W2891042090 hasAuthorship W2891042090A5058149977 @default.
• W2891042090 hasAuthorship W2891042090A5080250954 @default.
• W2891042090 hasAuthorship W2891042090A5086929851 @default.
• W2891042090 hasBestOaLocation W28910420901 @default.
• W2891042090 hasConcept C101666144 @default.
• W2891042090 hasConcept C126322002 @default.
• W2891042090 hasConcept C13373296 @default.
• W2891042090 hasConcept C134018914 @default.
• W2891042090 hasConcept C202751555 @default.
• W2891042090 hasConcept C2775858924 @default.
• W2891042090 hasConcept C2776914184 @default.

• next