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• W2891052260 abstract "Background: Maternal diet during pregnancy has been shown to influence the child neuro-developmental outcomes. Studies examining effects of dietary patterns on offspring behavior are sparse. Objective: Determine if maternal adherence to a Mediterranean diet is associated with child behavioral outcomes assessed early in life, and to evaluate the role of differentially methylated regions (DMRs) regulating genomically imprinted genes in these associations. Methods: Among 325 mother/infant pairs, we used regression models to evaluate the association between tertiles of maternal periconceptional Mediterranean diet adherence (MDA) scores derived from a Food Frequency Questionnaire, and social and emotional scores derived from the Infant Toddler Social and Emotional Assessment (ITSEA) questionnaire in the second year of life. Methylation of nine genomically imprinted genes was measured to determine if MDA was associated with CpG methylation. Results: Child depression was significantly associated with maternal MDA (Bonferroni-corrected p = 0.048). While controlling for false-discovery, compared to offspring of women with the lowest MDA tertile, those with MDA scores in middle and high MDA tertiles had decreased odds for atypical behaviors (OR (95%CI) = 0.40 (0.20, 0.78) for middle and 0.40 (0.17, 0.92) for highest tertile)), for maladaptive behaviors (0.37 (0.18, 0.72) for middle tertile and 0.42 (0.18, 0.95) for highest tertile) and for an index of autism spectrum disorder behaviors (0.46 (0.23, 0.90) for middle and 0.35 (0.15, 0.80) for highest tertile). Offspring of women with the highest MDA tertile were less likely to exhibit depressive (OR=0.28 (0.12, 0.64)) and anxiety (0.42 (0.18, 0.97)) behaviors and increased odds of social relatedness (2.31 (1.04, 5.19)) behaviors when compared to low MDA mothers. Some associations varied by sex. Perinatal MDA score was associated with methylation differences for imprinted control regions of PEG10/SGCE (females: Beta (95%CI) = 1.66 (0.52, 2.80) - Bonferroni-corrected p = 0.048; males: -0.56 (-1.13, -0.00)), as well as both MEG3 and IGF2 in males (0.97 (0.00, 1.94)) and -0.92 (-1.65, -0.19) respectively. Conclusions: In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs." @default.
• W2891052260 created "2018-09-27" @default.
• W2891052260 creator A5000205628 @default.
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• W2891052260 date "2018-09-07" @default.
• W2891052260 modified "2023-10-14" @default.
• W2891052260 title "Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes" @default.
• W2891052260 cites W1513618424 @default.
• W2891052260 cites W1549931432 @default.
• W2891052260 cites W1560520670 @default.
• W2891052260 cites W1579185664 @default.
• W2891052260 cites W1764553207 @default.
• W2891052260 cites W1820855395 @default.
• W2891052260 cites W1934656702 @default.
• W2891052260 cites W1958967044 @default.
• W2891052260 cites W1974300927 @default.
• W2891052260 cites W1974569044 @default.
• W2891052260 cites W1976542144 @default.
• W2891052260 cites W1981873184 @default.
• W2891052260 cites W1988219271 @default.
• W2891052260 cites W1988465169 @default.
• W2891052260 cites W1990570458 @default.
• W2891052260 cites W1998425791 @default.
• W2891052260 cites W1999943142 @default.
• W2891052260 cites W2000181161 @default.
• W2891052260 cites W2002163484 @default.
• W2891052260 cites W2003006766 @default.
• W2891052260 cites W2007817385 @default.
• W2891052260 cites W2010645487 @default.
• W2891052260 cites W2014433485 @default.
• W2891052260 cites W2015746229 @default.
• W2891052260 cites W2025828552 @default.
• W2891052260 cites W2027493903 @default.
• W2891052260 cites W2028462657 @default.
• W2891052260 cites W2032788228 @default.
• W2891052260 cites W2042334010 @default.
• W2891052260 cites W2046646957 @default.
• W2891052260 cites W2047547312 @default.
• W2891052260 cites W2051834276 @default.
• W2891052260 cites W2054077939 @default.
• W2891052260 cites W2054200483 @default.
• W2891052260 cites W2059475596 @default.
• W2891052260 cites W2072801868 @default.
• W2891052260 cites W2073640645 @default.
• W2891052260 cites W2083690675 @default.
• W2891052260 cites W2086029165 @default.
• W2891052260 cites W2089939809 @default.
• W2891052260 cites W2091981232 @default.
• W2891052260 cites W2092781707 @default.
• W2891052260 cites W2096031403 @default.
• W2891052260 cites W2098028662 @default.
• W2891052260 cites W2099176640 @default.
• W2891052260 cites W2100297272 @default.
• W2891052260 cites W2101940313 @default.
• W2891052260 cites W2103387193 @default.
• W2891052260 cites W2104792408 @default.
• W2891052260 cites W2106490877 @default.
• W2891052260 cites W2106686662 @default.
• W2891052260 cites W2107042561 @default.
• W2891052260 cites W2110506858 @default.
• W2891052260 cites W2110525019 @default.
• W2891052260 cites W2111418881 @default.
• W2891052260 cites W2113112389 @default.
• W2891052260 cites W2118793575 @default.
• W2891052260 cites W2126000893 @default.
• W2891052260 cites W2129246334 @default.
• W2891052260 cites W2131617895 @default.
• W2891052260 cites W2136206589 @default.
• W2891052260 cites W2136358279 @default.
• W2891052260 cites W2137779457 @default.
• W2891052260 cites W2146463166 @default.
• W2891052260 cites W2148462747 @default.
• W2891052260 cites W2150628272 @default.
• W2891052260 cites W2152436391 @default.
• W2891052260 cites W2158060077 @default.
• W2891052260 cites W2161089645 @default.
• W2891052260 cites W2167015768 @default.
• W2891052260 cites W2177368991 @default.
• W2891052260 cites W2179949314 @default.
• W2891052260 cites W2237525649 @default.
• W2891052260 cites W2239420344 @default.
• W2891052260 cites W2264936145 @default.
• W2891052260 cites W2274615431 @default.
• W2891052260 cites W2321428363 @default.
• W2891052260 cites W2335704194 @default.
• W2891052260 cites W2338546211 @default.
• W2891052260 cites W2339699192 @default.
• W2891052260 cites W2345953938 @default.
• W2891052260 cites W2347155688 @default.
• W2891052260 cites W2497480418 @default.
• W2891052260 cites W2513373784 @default.
• W2891052260 cites W2551628330 @default.

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