Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891053092> ?p ?o ?g. }
- W2891053092 endingPage "1105" @default.
- W2891053092 startingPage "1081" @default.
- W2891053092 abstract "NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-permeable component of excitatory neurotransmission in the central nervous system (CNS). They are expressed throughout the CNS and play key physiological roles in synaptic function, such as synaptic plasticity, learning, and memory. NMDA receptors are also implicated in the pathophysiology of several CNS disorders and more recently have been identified as a locus for disease-associated genomic variation. NMDA receptors exist as a diverse array of subtypes formed by variation in assembly of seven subunits (GluN1, GluN2A-D, and GluN3A-B) into tetrameric receptor complexes. These NMDA receptor subtypes show unique structural features that account for their distinct functional and pharmacological properties allowing precise tuning of their physiological roles. Here, we review the relationship between NMDA receptor structure and function with an emphasis on emerging atomic resolution structures, which begin to explain unique features of this receptor." @default.
- W2891053092 created "2018-09-27" @default.
- W2891053092 creator A5015251858 @default.
- W2891053092 creator A5018800292 @default.
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- W2891053092 creator A5039738992 @default.
- W2891053092 creator A5072982241 @default.
- W2891053092 creator A5083615197 @default.
- W2891053092 date "2018-07-23" @default.
- W2891053092 modified "2023-10-14" @default.
- W2891053092 title "Structure, function, and allosteric modulation of NMDA receptors" @default.
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