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- W2891053351 abstract "Autophagy is a conserved catabolic pathway with emerging functions in mammalian neurodevelopment and human neurodevelopmental diseases. The mechanisms controlling autophagy in neuronal development are not fully understood. Here, we found that conditional deletion of the Forkhead Box O transcription factors FoxO1, FoxO3, and FoxO4 strongly impaired autophagic flux in developing neurons of the adult mouse hippocampus. Moreover, FoxO deficiency led to altered dendritic morphology, increased spine density, and aberrant spine positioning in adult-generated neurons. Strikingly, pharmacological induction of autophagy was sufficient to correct abnormal dendrite and spine development of FoxO-deficient neurons. Collectively, these findings reveal a novel link between FoxO transcription factors, autophagic flux, and maturation of developing neurons." @default.
- W2891053351 created "2018-09-27" @default.
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- W2891053351 date "2018-09-01" @default.
- W2891053351 modified "2023-10-18" @default.
- W2891053351 title "FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis" @default.
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- W2891053351 doi "https://doi.org/10.1016/j.neuron.2018.08.017" @default.
- W2891053351 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186958" @default.