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• W2891054828 abstract "Background This meta‐analysis aimed to assess the cardiac safety profile of domperidone treatment for the risk of cardiovascular (CV) event and QT prolongation. Methods Data from nine studies involving 101,155 patients were used for the analysis of CV event risk, while data from eight studies involving 390 patients were used for the analysis of QT prolongation risk. Results Meta‐analysis findings suggested a significant increase in CV risk under domperidone as compared to no treatment for domperidone doses of >30 mg/day (OR: 3.14, 95% CI, 1.191 to 8.304, p = 0.021), no significant increase in QT prolongation event rates with domperidone (3.54%, 95% CI, 1.73% to 7.10%) and a significantly lower CV risk for domperidone than for metoclopramide (OR: 0.63, 95% CI, 0.58 to 0.70, p < 0.001). Conclusions The present meta‐analysis indicates that domperidone treatment may not be associated with an overall CV event risk increase at doses ≤30 mg/day and does not result in QT prolongation." @default.
• W2891054828 created "2018-09-27" @default.
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• W2891054828 date "2018-11-01" @default.
• W2891054828 modified "2023-09-26" @default.
• W2891054828 title "A meta‐analysis on the cardiac safety profile of domperidone compared to metoclopramide" @default.
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• W2891054828 doi "https://doi.org/10.1177/2050640618799153" @default.
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