FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891072134> ?p ?o ?g. }

• W2891072134 abstract "When draining lymph nodes become infected by Yersinia pestis (Y. pestis), a massive influx of phagocytic cells occurs, resulting in distended and necrotic structures known as buboes. The bubonic stage of the Y. pestis life cycle precedes septicemia, which is facilitated by trafficking of infected mononuclear phagocytes through these buboes. However, how Y. pestis convert these immunocytes recruited by host to contain the pathogen into vehicles for bacterial dispersal and the role of immune cell death in this context are unknown. We show that the lymphatic spread requires Yersinia outer protein J (YopJ), which triggers death of infected macrophages by downregulating a suppressor of receptor-interacting protein kinase 1–mediated (RIPK1-mediated) cell death programs. The YopJ-triggered cell death was identified as necroptotic, which released intracellular bacteria, allowing them to infect new neighboring cell targets. Dying macrophages also produced chemotactic sphingosine 1-phosphate, enhancing cell-to-cell contact, further promoting infection. This necroptosis-driven expansion of infected macrophages in buboes maximized the number of bacteria-bearing macrophages reaching secondary lymph nodes, leading to sepsis. In support, necrostatins confined bacteria within macrophages and protected mice from lethal infection. These findings define necrotization of buboes as a mechanism for bacterial spread and a potential target for therapeutic intervention." @default.
• W2891072134 created "2018-09-27" @default.
• W2891072134 creator A5013187415 @default.
• W2891072134 creator A5015291887 @default.
• W2891072134 creator A5030259389 @default.
• W2891072134 creator A5084537176 @default.
• W2891072134 creator A5088694505 @default.
• W2891072134 creator A5088859022 @default.
• W2891072134 date "2018-09-20" @default.
• W2891072134 modified "2023-09-25" @default.
• W2891072134 title "Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes" @default.
• W2891072134 cites W1957547301 @default.
• W2891072134 cites W1966369019 @default.
• W2891072134 cites W1973437785 @default.
• W2891072134 cites W1975593978 @default.
• W2891072134 cites W1982289244 @default.
• W2891072134 cites W1990424021 @default.
• W2891072134 cites W1991380853 @default.
• W2891072134 cites W1996162233 @default.
• W2891072134 cites W1998983498 @default.
• W2891072134 cites W2001366460 @default.
• W2891072134 cites W2002301651 @default.
• W2891072134 cites W2005473844 @default.
• W2891072134 cites W2008911461 @default.
• W2891072134 cites W2015354948 @default.
• W2891072134 cites W2020514731 @default.
• W2891072134 cites W2032897380 @default.
• W2891072134 cites W2048588387 @default.
• W2891072134 cites W2054941036 @default.
• W2891072134 cites W2059972136 @default.
• W2891072134 cites W2062306005 @default.
• W2891072134 cites W2071272846 @default.
• W2891072134 cites W2081053802 @default.
• W2891072134 cites W2087232320 @default.
• W2891072134 cites W2088573055 @default.
• W2891072134 cites W2090661916 @default.
• W2891072134 cites W2091018472 @default.
• W2891072134 cites W2093916833 @default.
• W2891072134 cites W2114832810 @default.
• W2891072134 cites W2116896168 @default.
• W2891072134 cites W2124202816 @default.
• W2891072134 cites W2136722399 @default.
• W2891072134 cites W2139552156 @default.
• W2891072134 cites W2145912774 @default.
• W2891072134 cites W2155850284 @default.
• W2891072134 cites W2158662692 @default.
• W2891072134 cites W2172282307 @default.
• W2891072134 cites W2319054200 @default.
• W2891072134 cites W2346022839 @default.
• W2891072134 cites W2517997111 @default.
• W2891072134 cites W2556305777 @default.
• W2891072134 cites W2584580415 @default.
• W2891072134 cites W2612992363 @default.
• W2891072134 cites W26583394 @default.
• W2891072134 cites W2751962761 @default.
• W2891072134 cites W2766414596 @default.
• W2891072134 cites W3025007532 @default.
• W2891072134 doi "https://doi.org/10.1172/jci.insight.122188" @default.
• W2891072134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237236" @default.
• W2891072134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30232285" @default.
• W2891072134 hasPublicationYear "2018" @default.
• W2891072134 type Work @default.
• W2891072134 sameAs 2891072134 @default.
• W2891072134 citedByCount "21" @default.
• W2891072134 countsByYear W28910721342019 @default.
• W2891072134 countsByYear W28910721342020 @default.
• W2891072134 countsByYear W28910721342021 @default.
• W2891072134 countsByYear W28910721342022 @default.
• W2891072134 countsByYear W28910721342023 @default.
• W2891072134 crossrefType "journal-article" @default.
• W2891072134 hasAuthorship W2891072134A5013187415 @default.
• W2891072134 hasAuthorship W2891072134A5015291887 @default.
• W2891072134 hasAuthorship W2891072134A5030259389 @default.
• W2891072134 hasAuthorship W2891072134A5084537176 @default.
• W2891072134 hasAuthorship W2891072134A5088694505 @default.
• W2891072134 hasAuthorship W2891072134A5088859022 @default.
• W2891072134 hasBestOaLocation W28910721341 @default.
• W2891072134 hasConcept C104317684 @default.
• W2891072134 hasConcept C153726182 @default.
• W2891072134 hasConcept C190283241 @default.
• W2891072134 hasConcept C203014093 @default.
• W2891072134 hasConcept C2776550021 @default.
• W2891072134 hasConcept C2777353990 @default.
• W2891072134 hasConcept C2778222588 @default.
• W2891072134 hasConcept C31573885 @default.
• W2891072134 hasConcept C55493867 @default.
• W2891072134 hasConcept C60987743 @default.
• W2891072134 hasConcept C79879829 @default.
• W2891072134 hasConcept C86803240 @default.
• W2891072134 hasConcept C8891405 @default.
• W2891072134 hasConcept C89423630 @default.
• W2891072134 hasConcept C94030615 @default.
• W2891072134 hasConcept C95444343 @default.
• W2891072134 hasConceptScore W2891072134C104317684 @default.
• W2891072134 hasConceptScore W2891072134C153726182 @default.
• W2891072134 hasConceptScore W2891072134C190283241 @default.
• W2891072134 hasConceptScore W2891072134C203014093 @default.
• W2891072134 hasConceptScore W2891072134C2776550021 @default.
• W2891072134 hasConceptScore W2891072134C2777353990 @default.
• W2891072134 hasConceptScore W2891072134C2778222588 @default.

• next