FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891073452> ?p ?o ?g. }

• W2891073452 abstract "Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) was found in HCC tissues, and which could affect HCC cells biological processes. However, the potential molecular mechanism of ANRIL in HCC is still unclear. The study aimed to uncover the effect of ANRIL on HepG2 cells growth, migration and invasion.The knockdown expression vectors of ANRIL were transfected into HepG2 cells, and qRT-PCR, CCK-8, flow cytometry, Transwell and western blot assays were performed to analyze the effect of ANRIL on cell proliferation, apoptosis, migration and invasion. The relative expression of miR-191 was then examined in ANRIL knockdown vector transfected cells. These experiments were repeated again for exploring the effect of miR-191 on HepG2 cells. NF-κB and Wnt/β-catenin signaling pathways were examined by using western blot assay.Knockdown of ANRIL inhibited proliferation, induced apoptosis, meanwhile suppressed migration and invasion of HepG2 cells. Additionally, the results showed that the expression level of miR-191 was down-regulated by ANRIL knockdown in HepG2 cells. Importantly, overexpression of miR-191 reversed the anti-tumor effect of ANRIL on cell proliferation, apoptosis, migration and invasion in HepG2 cells. Besides, we found that ANRIL knockdown inactivated NF-κB and Wnt/β-catenin pathways by regulating miR-191.These data demonstrated that ANRIL knockdown suppressed proliferation, migration, invasion, and promoted apoptosis in HepG2 cells by down-regulating miR-191 and inactivating NF-κB and Wnt/β-catenin signaling pathways." @default.
• W2891073452 created "2018-09-27" @default.
• W2891073452 creator A5001411084 @default.
• W2891073452 creator A5002656825 @default.
• W2891073452 creator A5016722004 @default.
• W2891073452 creator A5054408684 @default.
• W2891073452 creator A5068080767 @default.
• W2891073452 creator A5078689478 @default.
• W2891073452 creator A5085669615 @default.
• W2891073452 creator A5090366405 @default.
• W2891073452 date "2018-09-24" @default.
• W2891073452 modified "2023-10-17" @default.
• W2891073452 title "Knockdown long non-coding RNA ANRIL inhibits proliferation, migration and invasion of HepG2 cells by down-regulation of miR-191" @default.
• W2891073452 cites W129592507 @default.
• W2891073452 cites W1439006730 @default.
• W2891073452 cites W1573240323 @default.
• W2891073452 cites W1573789855 @default.
• W2891073452 cites W1896234258 @default.
• W2891073452 cites W1952134382 @default.
• W2891073452 cites W1967417833 @default.
• W2891073452 cites W2004714113 @default.
• W2891073452 cites W2015863218 @default.
• W2891073452 cites W2019122937 @default.
• W2891073452 cites W2027807256 @default.
• W2891073452 cites W2042720937 @default.
• W2891073452 cites W2044722598 @default.
• W2891073452 cites W2067765119 @default.
• W2891073452 cites W2088195401 @default.
• W2891073452 cites W2107303578 @default.
• W2891073452 cites W2109931287 @default.
• W2891073452 cites W2137794530 @default.
• W2891073452 cites W2164752294 @default.
• W2891073452 cites W2214897603 @default.
• W2891073452 cites W2421772005 @default.
• W2891073452 cites W2533778219 @default.
• W2891073452 cites W2565206604 @default.
• W2891073452 cites W2585615799 @default.
• W2891073452 cites W2588898490 @default.
• W2891073452 cites W2590925133 @default.
• W2891073452 cites W2606660292 @default.
• W2891073452 cites W2620345959 @default.
• W2891073452 cites W2747000876 @default.
• W2891073452 cites W2759367669 @default.
• W2891073452 cites W2761687184 @default.
• W2891073452 cites W2765722748 @default.
• W2891073452 cites W2766912540 @default.
• W2891073452 cites W2767886606 @default.
• W2891073452 cites W2778063035 @default.
• W2891073452 cites W2782884500 @default.
• W2891073452 cites W2792531398 @default.
• W2891073452 cites W2917837889 @default.
• W2891073452 cites W4232085893 @default.
• W2891073452 doi "https://doi.org/10.1186/s12885-018-4831-6" @default.
• W2891073452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6154945" @default.
• W2891073452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249208" @default.
• W2891073452 hasPublicationYear "2018" @default.
• W2891073452 type Work @default.
• W2891073452 sameAs 2891073452 @default.
• W2891073452 citedByCount "29" @default.
• W2891073452 countsByYear W28910734522019 @default.
• W2891073452 countsByYear W28910734522020 @default.
• W2891073452 countsByYear W28910734522021 @default.
• W2891073452 countsByYear W28910734522022 @default.
• W2891073452 countsByYear W28910734522023 @default.
• W2891073452 crossrefType "journal-article" @default.
• W2891073452 hasAuthorship W2891073452A5001411084 @default.
• W2891073452 hasAuthorship W2891073452A5002656825 @default.
• W2891073452 hasAuthorship W2891073452A5016722004 @default.
• W2891073452 hasAuthorship W2891073452A5054408684 @default.
• W2891073452 hasAuthorship W2891073452A5068080767 @default.
• W2891073452 hasAuthorship W2891073452A5078689478 @default.
• W2891073452 hasAuthorship W2891073452A5085669615 @default.
• W2891073452 hasAuthorship W2891073452A5090366405 @default.
• W2891073452 hasBestOaLocation W28910734521 @default.
• W2891073452 hasConcept C104317684 @default.
• W2891073452 hasConcept C137620995 @default.
• W2891073452 hasConcept C137738243 @default.
• W2891073452 hasConcept C1491633281 @default.
• W2891073452 hasConcept C153911025 @default.
• W2891073452 hasConcept C173396325 @default.
• W2891073452 hasConcept C185592680 @default.
• W2891073452 hasConcept C190283241 @default.
• W2891073452 hasConcept C502942594 @default.
• W2891073452 hasConcept C54009773 @default.
• W2891073452 hasConcept C54355233 @default.
• W2891073452 hasConcept C62112901 @default.
• W2891073452 hasConcept C62203573 @default.
• W2891073452 hasConcept C62478195 @default.
• W2891073452 hasConcept C67705224 @default.
• W2891073452 hasConcept C81885089 @default.
• W2891073452 hasConcept C86803240 @default.
• W2891073452 hasConcept C95444343 @default.
• W2891073452 hasConceptScore W2891073452C104317684 @default.
• W2891073452 hasConceptScore W2891073452C137620995 @default.
• W2891073452 hasConceptScore W2891073452C137738243 @default.
• W2891073452 hasConceptScore W2891073452C1491633281 @default.
• W2891073452 hasConceptScore W2891073452C153911025 @default.
• W2891073452 hasConceptScore W2891073452C173396325 @default.
• W2891073452 hasConceptScore W2891073452C185592680 @default.
• W2891073452 hasConceptScore W2891073452C190283241 @default.

• next