FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891078833> ?p ?o ?g. }

• W2891078833 endingPage "236" @default.
• W2891078833 startingPage "225" @default.
• W2891078833 abstract "Visfatin is an adipokine which has an endocrine effect on reproductive functions and regulates ovarian steroidogenesis. There is scant information about the expression, regulation, and functions of visfatin in the mammalian uterus. The present study examined expression and localization of visfatin in the mouse uterus at various stages of the natural estrous cycle, effects of estrogen and progesterone on localization and expression of visfatin in the ovariectomised mouse uterus and effect of visfatin inhibition by a specific inhibitor, FK866 on proliferation and apoptosis in the uterus. Western blot analysis of visfatin showed high expression in proestrus and metestrus while it declined in estrus and diestrus. Immulocalization study also showed strong immunostaining in the cells of endometrium, myometrium, luminal and glandular epithelium during proestrus and metestrus that estrus and diestrus. The uterine visfatin expression closely related to the increased estrogen levels in proestrus and suppressed when progesterone rose to a high level in diestrus. The treatment with estrogen to ovariectomised mice up-regulates visfatin, PCNA, and active caspase3 whereas progesterone up-regulates PCNA and down-regulates visfatin and active caspase3 expression in mouse uterus. The co-treatment with estrogen and progesterone up-regulates visfatin and down-regulates PCNA and active caspase3. In vitro study showed endogenous visfatin inhibition by FK866 increased expression of PCNA and BCL2 increased catalase activity while FK866 treatment decreased expression of active caspase3 and BAX with decreased SOD and GPx activity. BrdU labeling showed that inhibition of visfatin modulates the uterine proliferation. This study showed that expression of visfatin protein is steroid dependent in mouse uterus which is involved in the regulation of proliferation and apoptosis via modulating antioxidant system in the uterus of mice during the reproductive cycle." @default.
• W2891078833 created "2018-09-27" @default.
• W2891078833 creator A5003143095 @default.
• W2891078833 creator A5003682130 @default.
• W2891078833 creator A5015261199 @default.
• W2891078833 date "2019-01-01" @default.
• W2891078833 modified "2023-09-27" @default.
• W2891078833 title "Estrogen and progesterone dependent expression of visfatin/NAMPT regulates proliferation and apoptosis in mice uterus during estrous cycle" @default.
• W2891078833 cites W1481148238 @default.
• W2891078833 cites W1694069654 @default.
• W2891078833 cites W1969229097 @default.
• W2891078833 cites W1971619616 @default.
• W2891078833 cites W1978590803 @default.
• W2891078833 cites W1978996572 @default.
• W2891078833 cites W1986238452 @default.
• W2891078833 cites W1991553723 @default.
• W2891078833 cites W1998767886 @default.
• W2891078833 cites W2000339122 @default.
• W2891078833 cites W2010303619 @default.
• W2891078833 cites W2016006057 @default.
• W2891078833 cites W2035750052 @default.
• W2891078833 cites W2038740845 @default.
• W2891078833 cites W2042152630 @default.
• W2891078833 cites W2050668885 @default.
• W2891078833 cites W2051051060 @default.
• W2891078833 cites W2052671441 @default.
• W2891078833 cites W2057519141 @default.
• W2891078833 cites W2059778973 @default.
• W2891078833 cites W2060269801 @default.
• W2891078833 cites W2061310823 @default.
• W2891078833 cites W2061354027 @default.
• W2891078833 cites W2062344353 @default.
• W2891078833 cites W2068180728 @default.
• W2891078833 cites W2073278300 @default.
• W2891078833 cites W2076738420 @default.
• W2891078833 cites W2078606682 @default.
• W2891078833 cites W2084398491 @default.
• W2891078833 cites W2088940658 @default.
• W2891078833 cites W2095333638 @default.
• W2891078833 cites W2095393797 @default.
• W2891078833 cites W2101422765 @default.
• W2891078833 cites W2102800356 @default.
• W2891078833 cites W2104625179 @default.
• W2891078833 cites W2105040246 @default.
• W2891078833 cites W2112376881 @default.
• W2891078833 cites W2118197078 @default.
• W2891078833 cites W2118647245 @default.
• W2891078833 cites W2124312207 @default.
• W2891078833 cites W2130765681 @default.
• W2891078833 cites W2135110328 @default.
• W2891078833 cites W2139088926 @default.
• W2891078833 cites W2140793920 @default.
• W2891078833 cites W2151005604 @default.
• W2891078833 cites W2155867477 @default.
• W2891078833 cites W2157292968 @default.
• W2891078833 cites W2172189712 @default.
• W2891078833 cites W2256378035 @default.
• W2891078833 cites W2276792665 @default.
• W2891078833 cites W2294249660 @default.
• W2891078833 cites W2396871358 @default.
• W2891078833 cites W2478386963 @default.
• W2891078833 cites W2551785631 @default.
• W2891078833 cites W2566622217 @default.
• W2891078833 cites W2583744084 @default.
• W2891078833 cites W2584840157 @default.
• W2891078833 cites W2606514169 @default.
• W2891078833 cites W2621308663 @default.
• W2891078833 cites W4293247451 @default.
• W2891078833 doi "https://doi.org/10.1016/j.jsbmb.2018.09.010" @default.
• W2891078833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227242" @default.
• W2891078833 hasPublicationYear "2019" @default.
• W2891078833 type Work @default.
• W2891078833 sameAs 2891078833 @default.
• W2891078833 citedByCount "30" @default.
• W2891078833 countsByYear W28910788332019 @default.
• W2891078833 countsByYear W28910788332020 @default.
• W2891078833 countsByYear W28910788332021 @default.
• W2891078833 countsByYear W28910788332022 @default.
• W2891078833 countsByYear W28910788332023 @default.
• W2891078833 crossrefType "journal-article" @default.
• W2891078833 hasAuthorship W2891078833A5003143095 @default.
• W2891078833 hasAuthorship W2891078833A5003682130 @default.
• W2891078833 hasAuthorship W2891078833A5015261199 @default.
• W2891078833 hasConcept C126322002 @default.
• W2891078833 hasConcept C134018914 @default.
• W2891078833 hasConcept C1998276 @default.
• W2891078833 hasConcept C2777164284 @default.
• W2891078833 hasConcept C2779066055 @default.
• W2891078833 hasConcept C71924100 @default.
• W2891078833 hasConcept C86803240 @default.
• W2891078833 hasConceptScore W2891078833C126322002 @default.
• W2891078833 hasConceptScore W2891078833C134018914 @default.
• W2891078833 hasConceptScore W2891078833C1998276 @default.
• W2891078833 hasConceptScore W2891078833C2777164284 @default.
• W2891078833 hasConceptScore W2891078833C2779066055 @default.
• W2891078833 hasConceptScore W2891078833C71924100 @default.
• W2891078833 hasConceptScore W2891078833C86803240 @default.
• W2891078833 hasFunder F4320320719 @default.

• next