Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891084049> ?p ?o ?g. }
- W2891084049 endingPage "580" @default.
- W2891084049 startingPage "569" @default.
- W2891084049 abstract "Mitochondria are currently known as novel targets for treating cancer, especially for tumors displaying multidrug resistance (MDR). This present study aimed to develop a mitochondria-targeted delivery system by using triphenylphosphonium cation (TPP+)-conjugated Brij 98 as the functional stabilizer to modify paclitaxel (PTX) nanocrystals (NCs) against drug-resistant cancer cells. Evaluations were performed on 2D monolayer and 3D multicellular spheroids (MCs) of MCF-7 cells and MCF-7/ADR cells. In comparison with free PTX and the non-targeted PTX NCs, the targeted PTX NCs showed the strongest cytotoxicity against both 2D MCF-7 and MCF-7/ADR cells, which was correlated with decreased mitochondrial membrane potential. The targeted PTX NCs exhibited deeper penetration on MCF-7 MCs and more significant growth inhibition on both MCF-7 and MCF-7/ADR MCs. The proposed strategy indicated that the TPP+-modified NCs represent a potentially viable approach for targeted chemotherapeutic molecules to mitochondria. This strategy might provide promising therapeutic outcomes to overcome MDR." @default.
- W2891084049 created "2018-09-27" @default.
- W2891084049 creator A5003395715 @default.
- W2891084049 creator A5004553261 @default.
- W2891084049 creator A5014173912 @default.
- W2891084049 creator A5019551624 @default.
- W2891084049 creator A5023152887 @default.
- W2891084049 creator A5024848339 @default.
- W2891084049 creator A5055389013 @default.
- W2891084049 date "2019-09-01" @default.
- W2891084049 modified "2023-10-17" @default.
- W2891084049 title "Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance" @default.
- W2891084049 cites W1677199798 @default.
- W2891084049 cites W1990937156 @default.
- W2891084049 cites W1993373375 @default.
- W2891084049 cites W1994354502 @default.
- W2891084049 cites W1998492012 @default.
- W2891084049 cites W2001110762 @default.
- W2891084049 cites W2001610336 @default.
- W2891084049 cites W2002486553 @default.
- W2891084049 cites W2003110090 @default.
- W2891084049 cites W2003335129 @default.
- W2891084049 cites W2004934153 @default.
- W2891084049 cites W2009680181 @default.
- W2891084049 cites W2012889594 @default.
- W2891084049 cites W2012996470 @default.
- W2891084049 cites W2021680808 @default.
- W2891084049 cites W2036671354 @default.
- W2891084049 cites W2038232490 @default.
- W2891084049 cites W2040683552 @default.
- W2891084049 cites W2078053367 @default.
- W2891084049 cites W2099653180 @default.
- W2891084049 cites W2105876629 @default.
- W2891084049 cites W2129276841 @default.
- W2891084049 cites W2149064045 @default.
- W2891084049 cites W2149959721 @default.
- W2891084049 cites W2170663303 @default.
- W2891084049 cites W2313304731 @default.
- W2891084049 cites W2317124209 @default.
- W2891084049 cites W2405553906 @default.
- W2891084049 cites W2500682313 @default.
- W2891084049 cites W2528055649 @default.
- W2891084049 cites W2529586600 @default.
- W2891084049 cites W2610788148 @default.
- W2891084049 cites W2613630131 @default.
- W2891084049 cites W2613959205 @default.
- W2891084049 cites W2723060781 @default.
- W2891084049 cites W2726063857 @default.
- W2891084049 cites W2734768350 @default.
- W2891084049 cites W2757407086 @default.
- W2891084049 cites W2762360743 @default.
- W2891084049 cites W2767577044 @default.
- W2891084049 cites W2771049469 @default.
- W2891084049 doi "https://doi.org/10.1016/j.ajps.2018.06.006" @default.
- W2891084049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7032231" @default.
- W2891084049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32104484" @default.
- W2891084049 hasPublicationYear "2019" @default.
- W2891084049 type Work @default.
- W2891084049 sameAs 2891084049 @default.
- W2891084049 citedByCount "31" @default.
- W2891084049 countsByYear W28910840492019 @default.
- W2891084049 countsByYear W28910840492020 @default.
- W2891084049 countsByYear W28910840492021 @default.
- W2891084049 countsByYear W28910840492022 @default.
- W2891084049 countsByYear W28910840492023 @default.
- W2891084049 crossrefType "journal-article" @default.
- W2891084049 hasAuthorship W2891084049A5003395715 @default.
- W2891084049 hasAuthorship W2891084049A5004553261 @default.
- W2891084049 hasAuthorship W2891084049A5014173912 @default.
- W2891084049 hasAuthorship W2891084049A5019551624 @default.
- W2891084049 hasAuthorship W2891084049A5023152887 @default.
- W2891084049 hasAuthorship W2891084049A5024848339 @default.
- W2891084049 hasAuthorship W2891084049A5055389013 @default.
- W2891084049 hasBestOaLocation W28910840491 @default.
- W2891084049 hasConcept C109316439 @default.
- W2891084049 hasConcept C114851261 @default.
- W2891084049 hasConcept C121608353 @default.
- W2891084049 hasConcept C126322002 @default.
- W2891084049 hasConcept C133936738 @default.
- W2891084049 hasConcept C185592680 @default.
- W2891084049 hasConcept C190283241 @default.
- W2891084049 hasConcept C202751555 @default.
- W2891084049 hasConcept C2777292972 @default.
- W2891084049 hasConcept C28859421 @default.
- W2891084049 hasConcept C501593827 @default.
- W2891084049 hasConcept C502942594 @default.
- W2891084049 hasConcept C55493867 @default.
- W2891084049 hasConcept C71924100 @default.
- W2891084049 hasConcept C86803240 @default.
- W2891084049 hasConcept C89423630 @default.
- W2891084049 hasConcept C96232424 @default.
- W2891084049 hasConcept C98274493 @default.
- W2891084049 hasConceptScore W2891084049C109316439 @default.
- W2891084049 hasConceptScore W2891084049C114851261 @default.
- W2891084049 hasConceptScore W2891084049C121608353 @default.
- W2891084049 hasConceptScore W2891084049C126322002 @default.
- W2891084049 hasConceptScore W2891084049C133936738 @default.
- W2891084049 hasConceptScore W2891084049C185592680 @default.