FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891088504> ?p ?o ?g. }

• W2891088504 endingPage "1550" @default.
• W2891088504 startingPage "1544" @default.
• W2891088504 abstract "Two water-soluble polysaccharides named CPP1a and CPP1c were isolated from C. pilosula Nannf. var. modesta L.T.Shen by hot-water extraction and purified by graded alcohol precipitation and DEAE-52 cellulose column. The structure of CPP1c with higher yield has been characterized while its antitumor activities has not been elucidated. In this study, we firstly analyzed the chemical structure of CPP1a. The results of instrumental analysis combined with chemical analysis showed that CPP1a was composed of →1)- β‑l‑Rhap‑(4→, →1)- β‑Arap‑(5→, →1)- β‑d‑GalpA‑(4→, →1)- β‑d‑Galp‑(6→, terminal‑β‑d‑Glcp in a molar ratio of 1:12:1:10:3 and its relative and absolute molecular weight were 1.01 × 105 Da and 1.03 × 105 Da respectively. Further, the cytotoxicity assay indicated that CPP1a and CPP1c were more sensitive to HepG2 cells than cervical carcinoma Hela cells and gastric carcinoma MKN45 cells. Both of CPP1a and CPP1c could influence cell morphology, inhibit the migration and induce apoptosis by affecting the G2/M phase of HepG2 cells. Preliminary mechanism studies confirmed that CPP1a and CPP1c could induce apoptosis through up-regulating the ratio of Bax/Bcl-2 and activating caspase-3. According to previous research, we might speculate that the reason for the stronger cytotoxicity and pro-apoptotic effect of CPP1c than that of CPP1a can be attributed to its high uronic acid content." @default.
• W2891088504 created "2018-09-27" @default.
• W2891088504 creator A5005215310 @default.
• W2891088504 creator A5012051639 @default.
• W2891088504 creator A5023394614 @default.
• W2891088504 creator A5039207465 @default.
• W2891088504 creator A5065273787 @default.
• W2891088504 creator A5081813017 @default.
• W2891088504 creator A5082234675 @default.
• W2891088504 date "2018-12-01" @default.
• W2891088504 modified "2023-09-29" @default.
• W2891088504 title "Cytotoxicity of two water-soluble polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L.T.Shen against human hepatocellular carcinoma HepG2 cells and its mechanism" @default.
• W2891088504 cites W1965083187 @default.
• W2891088504 cites W1967913284 @default.
• W2891088504 cites W1969015047 @default.
• W2891088504 cites W1969382600 @default.
• W2891088504 cites W1971230960 @default.
• W2891088504 cites W1973967253 @default.
• W2891088504 cites W1981365194 @default.
• W2891088504 cites W1997268490 @default.
• W2891088504 cites W1997863511 @default.
• W2891088504 cites W1998023330 @default.
• W2891088504 cites W2002981217 @default.
• W2891088504 cites W2009096884 @default.
• W2891088504 cites W2013098957 @default.
• W2891088504 cites W2013503255 @default.
• W2891088504 cites W2026305726 @default.
• W2891088504 cites W2029157729 @default.
• W2891088504 cites W2032828829 @default.
• W2891088504 cites W2039512150 @default.
• W2891088504 cites W2063252342 @default.
• W2891088504 cites W2069166544 @default.
• W2891088504 cites W2070704969 @default.
• W2891088504 cites W2076615302 @default.
• W2891088504 cites W2086947055 @default.
• W2891088504 cites W2095479445 @default.
• W2891088504 cites W2163347536 @default.
• W2891088504 cites W2196208937 @default.
• W2891088504 cites W2300083744 @default.
• W2891088504 cites W2463475103 @default.
• W2891088504 cites W2508036849 @default.
• W2891088504 cites W2520855004 @default.
• W2891088504 cites W2525166379 @default.
• W2891088504 cites W2528949276 @default.
• W2891088504 cites W2580567425 @default.
• W2891088504 cites W2591131220 @default.
• W2891088504 cites W2807640523 @default.
• W2891088504 cites W419122150 @default.
• W2891088504 doi "https://doi.org/10.1016/j.ijbiomac.2018.09.123" @default.
• W2891088504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248423" @default.
• W2891088504 hasPublicationYear "2018" @default.
• W2891088504 type Work @default.
• W2891088504 sameAs 2891088504 @default.
• W2891088504 citedByCount "46" @default.
• W2891088504 countsByYear W28910885042019 @default.
• W2891088504 countsByYear W28910885042020 @default.
• W2891088504 countsByYear W28910885042021 @default.
• W2891088504 countsByYear W28910885042022 @default.
• W2891088504 countsByYear W28910885042023 @default.
• W2891088504 crossrefType "journal-article" @default.
• W2891088504 hasAuthorship W2891088504A5005215310 @default.
• W2891088504 hasAuthorship W2891088504A5012051639 @default.
• W2891088504 hasAuthorship W2891088504A5023394614 @default.
• W2891088504 hasAuthorship W2891088504A5039207465 @default.
• W2891088504 hasAuthorship W2891088504A5065273787 @default.
• W2891088504 hasAuthorship W2891088504A5081813017 @default.
• W2891088504 hasAuthorship W2891088504A5082234675 @default.
• W2891088504 hasConcept C100817775 @default.
• W2891088504 hasConcept C109316439 @default.
• W2891088504 hasConcept C153911025 @default.
• W2891088504 hasConcept C185592680 @default.
• W2891088504 hasConcept C190283241 @default.
• W2891088504 hasConcept C202751555 @default.
• W2891088504 hasConcept C2777366897 @default.
• W2891088504 hasConcept C2778019345 @default.
• W2891088504 hasConcept C2778284416 @default.
• W2891088504 hasConcept C2780161600 @default.
• W2891088504 hasConcept C502942594 @default.
• W2891088504 hasConcept C55493867 @default.
• W2891088504 hasConcept C86803240 @default.
• W2891088504 hasConceptScore W2891088504C100817775 @default.
• W2891088504 hasConceptScore W2891088504C109316439 @default.
• W2891088504 hasConceptScore W2891088504C153911025 @default.
• W2891088504 hasConceptScore W2891088504C185592680 @default.
• W2891088504 hasConceptScore W2891088504C190283241 @default.
• W2891088504 hasConceptScore W2891088504C202751555 @default.
• W2891088504 hasConceptScore W2891088504C2777366897 @default.
• W2891088504 hasConceptScore W2891088504C2778019345 @default.
• W2891088504 hasConceptScore W2891088504C2778284416 @default.
• W2891088504 hasConceptScore W2891088504C2780161600 @default.
• W2891088504 hasConceptScore W2891088504C502942594 @default.
• W2891088504 hasConceptScore W2891088504C55493867 @default.
• W2891088504 hasConceptScore W2891088504C86803240 @default.
• W2891088504 hasFunder F4320325927 @default.
• W2891088504 hasLocation W28910885041 @default.
• W2891088504 hasLocation W28910885042 @default.
• W2891088504 hasOpenAccess W2891088504 @default.
• W2891088504 hasPrimaryLocation W28910885041 @default.

• next