FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891091085> ?p ?o ?g. }

• W2891091085 endingPage "1791" @default.
• W2891091085 startingPage "1782" @default.
• W2891091085 abstract "Lysine-specific demethylase 1 (LSD1) is one of the flavin-dependent oxidases and is involved in many cellular processes by controlling the methylation of histone H3. Recently, it has been reported that LSD1 is associated with several diseases such as cancer, metabolic disorders, and psychiatric diseases. Thus, LSD1 is an attractive molecular target for the treatment of these diseases, and its inhibitors are predicted as therapeutic agents. Although a variety of LSD1 inhibitors have been reported to date, many of them show insufficient activities and selectivity toward LSD1. Meanwhile, we identified several LSD1-selective inhibitors using target-guided synthesis strategies based on our original ideas. Our LSD1 inhibitors show not only potent LSD1-selective inhibitory activities, but also unique bioactivities both in vitro and in vivo. This account highlights our drug design concepts for and identification of LSD1-selective inhibitors." @default.
• W2891091085 created "2018-09-27" @default.
• W2891091085 creator A5014972330 @default.
• W2891091085 creator A5044997693 @default.
• W2891091085 date "2018-09-11" @default.
• W2891091085 modified "2023-10-16" @default.
• W2891091085 title "Drug Design Concepts for LSD1‐Selective Inhibitors" @default.
• W2891091085 cites W1603797292 @default.
• W2891091085 cites W1830559800 @default.
• W2891091085 cites W1978820716 @default.
• W2891091085 cites W1978876482 @default.
• W2891091085 cites W1985159629 @default.
• W2891091085 cites W1985444222 @default.
• W2891091085 cites W1985712067 @default.
• W2891091085 cites W1994287097 @default.
• W2891091085 cites W2001232767 @default.
• W2891091085 cites W2001417240 @default.
• W2891091085 cites W2006229882 @default.
• W2891091085 cites W2009089729 @default.
• W2891091085 cites W2010407535 @default.
• W2891091085 cites W2013810007 @default.
• W2891091085 cites W2014021851 @default.
• W2891091085 cites W2019620912 @default.
• W2891091085 cites W2019712140 @default.
• W2891091085 cites W2024770800 @default.
• W2891091085 cites W2034191525 @default.
• W2891091085 cites W2040025688 @default.
• W2891091085 cites W2040365591 @default.
• W2891091085 cites W2048082241 @default.
• W2891091085 cites W2050723217 @default.
• W2891091085 cites W2054153251 @default.
• W2891091085 cites W2054621094 @default.
• W2891091085 cites W2058223580 @default.
• W2891091085 cites W2068166663 @default.
• W2891091085 cites W2068201305 @default.
• W2891091085 cites W2069010058 @default.
• W2891091085 cites W2072677280 @default.
• W2891091085 cites W2081567264 @default.
• W2891091085 cites W2092282705 @default.
• W2891091085 cites W2094221767 @default.
• W2891091085 cites W2097599440 @default.
• W2891091085 cites W2099050199 @default.
• W2891091085 cites W2102044580 @default.
• W2891091085 cites W2102156431 @default.
• W2891091085 cites W2104209180 @default.
• W2891091085 cites W2112494606 @default.
• W2891091085 cites W2120450507 @default.
• W2891091085 cites W2122814930 @default.
• W2891091085 cites W2125161768 @default.
• W2891091085 cites W2126504590 @default.
• W2891091085 cites W2137678309 @default.
• W2891091085 cites W2138220879 @default.
• W2891091085 cites W2139977642 @default.
• W2891091085 cites W2143658931 @default.
• W2891091085 cites W2147439095 @default.
• W2891091085 cites W2157771031 @default.
• W2891091085 cites W2163767810 @default.
• W2891091085 cites W2168582787 @default.
• W2891091085 cites W2171598595 @default.
• W2891091085 cites W2190862378 @default.
• W2891091085 cites W2197346077 @default.
• W2891091085 cites W2259755988 @default.
• W2891091085 cites W2268683612 @default.
• W2891091085 cites W2275087445 @default.
• W2891091085 cites W2288097186 @default.
• W2891091085 cites W2312844872 @default.
• W2891091085 cites W2315254005 @default.
• W2891091085 cites W2334698107 @default.
• W2891091085 cites W2340876231 @default.
• W2891091085 cites W2396035051 @default.
• W2891091085 cites W2407406252 @default.
• W2891091085 cites W2413188065 @default.
• W2891091085 cites W2425374734 @default.
• W2891091085 cites W2460507268 @default.
• W2891091085 cites W2507527547 @default.
• W2891091085 cites W2520154031 @default.
• W2891091085 cites W2551819484 @default.
• W2891091085 cites W2559423762 @default.
• W2891091085 cites W2582322962 @default.
• W2891091085 cites W2586445984 @default.
• W2891091085 cites W2588321737 @default.
• W2891091085 cites W2600734330 @default.
• W2891091085 cites W2602027562 @default.
• W2891091085 cites W2618283214 @default.
• W2891091085 cites W2627044895 @default.
• W2891091085 cites W2738161330 @default.
• W2891091085 cites W2739264716 @default.
• W2891091085 cites W2760255113 @default.
• W2891091085 cites W2769426369 @default.
• W2891091085 cites W2781956532 @default.
• W2891091085 cites W2784788365 @default.
• W2891091085 cites W2786022490 @default.
• W2891091085 cites W2789533953 @default.
• W2891091085 cites W2794180511 @default.
• W2891091085 cites W4212766227 @default.
• W2891091085 cites W4236664640 @default.
• W2891091085 cites W4244691648 @default.
• W2891091085 cites W4249984318 @default.

• next