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• W2891093378 abstract "<b><i>Objective:</i></b> Lysozyme and lactoferrin have anti-candidal activity. <i>Candida dubliniensis</i> is associated with oral candidiasis. <i>Candida</i> infections are managed with nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine. <i>Candida</i> species undergo a brief exposure to therapeutic agents in the mouth. There is no data on the influence of limited exposure to antimycotics on the sensitivity of <i>C. dubliniensis</i> to lactoferrin and lysozyme. Hence, this study observed the changes in the sensitivity of <i>C. dubliniensis</i> to anti-candidal action of lactoferrin and lysozyme after transitory exposure to sub-lethal concentrations of antifungals. <b><i>Materials and Methods:</i></b> After determination of the minimum inhibitory concentration (MIC), 20 <i>C. dubliniensis</i> isolates were exposed to twice the concentration of MIC of nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine for 1 h. Drugs were removed by dilution and thereafter the susceptibility of these isolates to lysozyme and lactoferrin was determined by colony-forming unit quantification assay. <b><i>Results:</i></b> Exposure of <i>C. dubliniensis</i> to nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine resulted in an increase in susceptibility to lysozyme by 9.45, 30.82, 30.04, 50.64, 55.60, and 50.18%, respectively (<i>p</i> &#x3c; 0.05 to <i>p</i> <i>&#x3c;</i> 0.001). Exposure of <i>C. dubliniensis</i> to nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine resulted in an increase in susceptibility to lactoferrin by 13.54, 16.43, 17.58, 19.60, 21.32, and 18.73, respectively (<i>p</i> &#x3c; 0.05 to <i>p &#x3c;</i> 0.001). <b><i>Conclusion:</i></b> Brief exposure to nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine enhances the antifungal effect of lysozyme and lactoferrin on <i>C. dubliniensis</i> isolates in vitro." @default.
• W2891093378 created "2018-09-27" @default.
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• W2891093378 date "2018-01-01" @default.
• W2891093378 modified "2023-09-28" @default.
• W2891093378 title "Impact of Brief Exposure to Drugs with Antifungal Properties on the Susceptibility of Oral Candida dubliniensis Isolates to Lysozyme and Lactoferrin" @default.
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• W2891093378 doi "https://doi.org/10.1159/000493391" @default.
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