Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891094027> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2891094027 abstract "Author(s): Cao, Kevin Jay | Advisor(s): Yang, Jerry C | Abstract: At the molecular level, neurodegeneration is characterized by the appearance of aggregates of misfolded proteins known as amyloids. These assemblies are often associated with neurotoxicity and are classically the defining feature of neurodegenerative diseases such as Alzheimer’s Disease (AD). The appearance of these aggregates in the brain often preludes the clinical symptoms of neurodegeneration, and thus are valuable targets for the early diagnoses of the diseases. This thesis documents the development of amino-naphthalene cyanoacrylate (ANCA) fluorophores and their use towards detecting these amyloid aggregates. Chapters 2 and 3 describe the rational design and synthesis of the ANCA family and their colorimetric sensitivity to different amyloid species. This unique capability was found to originate from their environmentally sensitive molecular structure, which was utilized to characterize amyloids based on their fluorescence emission lambda max. Chapter 4 describes the development of an in vivo imaging methodology to detect amyloidosis in the retina of AD and prion mice using the fluorescence of an ANCA derivative, ARCAM-1. This preliminary study on retinal imaging supports the use of the eye as a window to peer into the central nervous system. Finally, Chapter 5 presents the utility of ARCAM-1 as a sensor for the detection of the smaller, transient oligomeric amyloid species by use of fluorescence correlation spectroscopy (FCS), and as a sensor for amyloidosis in the urine of pregnant women with pre-eclampsia (PE)." @default.
- W2891094027 created "2018-09-27" @default.
- W2891094027 creator A5014891096 @default.
- W2891094027 date "2016-01-01" @default.
- W2891094027 modified "2023-09-23" @default.
- W2891094027 title "Development of Fluorescent Methods for the Detection of Amyloidosis in Neurodegeneration" @default.
- W2891094027 hasPublicationYear "2016" @default.
- W2891094027 type Work @default.
- W2891094027 sameAs 2891094027 @default.
- W2891094027 citedByCount "0" @default.
- W2891094027 crossrefType "journal-article" @default.
- W2891094027 hasAuthorship W2891094027A5014891096 @default.
- W2891094027 hasConcept C121332964 @default.
- W2891094027 hasConcept C142724271 @default.
- W2891094027 hasConcept C169760540 @default.
- W2891094027 hasConcept C185592680 @default.
- W2891094027 hasConcept C2776925932 @default.
- W2891094027 hasConcept C2777633098 @default.
- W2891094027 hasConcept C2779134260 @default.
- W2891094027 hasConcept C2779951007 @default.
- W2891094027 hasConcept C62520636 @default.
- W2891094027 hasConcept C71924100 @default.
- W2891094027 hasConcept C86803240 @default.
- W2891094027 hasConcept C91881484 @default.
- W2891094027 hasConceptScore W2891094027C121332964 @default.
- W2891094027 hasConceptScore W2891094027C142724271 @default.
- W2891094027 hasConceptScore W2891094027C169760540 @default.
- W2891094027 hasConceptScore W2891094027C185592680 @default.
- W2891094027 hasConceptScore W2891094027C2776925932 @default.
- W2891094027 hasConceptScore W2891094027C2777633098 @default.
- W2891094027 hasConceptScore W2891094027C2779134260 @default.
- W2891094027 hasConceptScore W2891094027C2779951007 @default.
- W2891094027 hasConceptScore W2891094027C62520636 @default.
- W2891094027 hasConceptScore W2891094027C71924100 @default.
- W2891094027 hasConceptScore W2891094027C86803240 @default.
- W2891094027 hasConceptScore W2891094027C91881484 @default.
- W2891094027 hasLocation W28910940271 @default.
- W2891094027 hasOpenAccess W2891094027 @default.
- W2891094027 hasPrimaryLocation W28910940271 @default.
- W2891094027 hasRelatedWork W119675255 @default.
- W2891094027 hasRelatedWork W1555242229 @default.
- W2891094027 hasRelatedWork W190061041 @default.
- W2891094027 hasRelatedWork W1968224331 @default.
- W2891094027 hasRelatedWork W1991805750 @default.
- W2891094027 hasRelatedWork W2027442107 @default.
- W2891094027 hasRelatedWork W2044826697 @default.
- W2891094027 hasRelatedWork W2056597104 @default.
- W2891094027 hasRelatedWork W2073464277 @default.
- W2891094027 hasRelatedWork W2125757707 @default.
- W2891094027 hasRelatedWork W2147638023 @default.
- W2891094027 hasRelatedWork W2414281610 @default.
- W2891094027 hasRelatedWork W2736908165 @default.
- W2891094027 hasRelatedWork W2751899177 @default.
- W2891094027 hasRelatedWork W2774913368 @default.
- W2891094027 hasRelatedWork W2973598512 @default.
- W2891094027 hasRelatedWork W3004475249 @default.
- W2891094027 hasRelatedWork W3150252105 @default.
- W2891094027 hasRelatedWork W3158996866 @default.
- W2891094027 hasRelatedWork W2109221961 @default.
- W2891094027 isParatext "false" @default.
- W2891094027 isRetracted "false" @default.
- W2891094027 magId "2891094027" @default.
- W2891094027 workType "article" @default.