FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891096074> ?p ?o ?g. }

• W2891096074 abstract "Specialists in addiction medicine continue to debate whether baclofen is still indicated to treat alcohol use disorders in view of conflicting results as to its efficacy. This review summarizes current knowledge on self-poisoning with baclofen focusing of alcohol-use disorder in order to provide an overview of the reliable scientific knowledge on management of such an intoxication. Moreover, as alcohol-dependent patients experience many psychiatric co-morbidities, the risk in suicide attempt using baclofen seems real. Numerous studies have suggested that patients given daily-doses of baclofen higher than 80 mg/day are more likely to attempt suicides than others. Following an ingestion of a large amount of baclofen, central nervous system depression is usually observed. Seizures require the patient to be admitted in intensive care unit and should be treated like other toxicological seizures. Cardiac complications include prolonged QTc interval, degree heart block, premature atrial contractions, and supraventricular tachycardia, hypotension and bradycardia. In cases of intoxication, the elimination half-life of baclofen may last between 12 and 36 h post-overdose and renal failure is known to delay its clearance. Rarely measured in clinical practice, the toxic level of baclofen blood level ranges from 1.1 to 3.5 mg/l, and coma or fatal intoxication are observed from 6 to 9.6 mg/. Baclofen withdrawal has been observed but making the diagnosis of withdrawal in case of suspected self-poisoning is difficult as baclofen intoxication and baclofen withdrawal share many clinical signs. Admission to hospital to manage of suicide attempt with baclofen is mandatory and should not be limited to baclofen alone. It needs to include other aspects of the overall care of patients with alcohol disorders (psychological and psychosocial interventions, management of comorbid mental conditions and physical complications)." @default.
• W2891096074 created "2018-09-27" @default.
• W2891096074 creator A5003391709 @default.
• W2891096074 creator A5022809900 @default.
• W2891096074 creator A5063118702 @default.
• W2891096074 creator A5083462165 @default.
• W2891096074 date "2018-09-04" @default.
• W2891096074 modified "2023-10-14" @default.
• W2891096074 title "How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates" @default.
• W2891096074 cites W1589454228 @default.
• W2891096074 cites W1802167042 @default.
• W2891096074 cites W1876827663 @default.
• W2891096074 cites W1965953580 @default.
• W2891096074 cites W1984305071 @default.
• W2891096074 cites W1997121650 @default.
• W2891096074 cites W1999537503 @default.
• W2891096074 cites W2036254563 @default.
• W2891096074 cites W2042421076 @default.
• W2891096074 cites W2053050909 @default.
• W2891096074 cites W2056339411 @default.
• W2891096074 cites W2059557922 @default.
• W2891096074 cites W2073663966 @default.
• W2891096074 cites W2073692266 @default.
• W2891096074 cites W2078594409 @default.
• W2891096074 cites W2101997000 @default.
• W2891096074 cites W2115467627 @default.
• W2891096074 cites W2136006910 @default.
• W2891096074 cites W2136475835 @default.
• W2891096074 cites W2145176659 @default.
• W2891096074 cites W2148671901 @default.
• W2891096074 cites W2149419184 @default.
• W2891096074 cites W2161224937 @default.
• W2891096074 cites W2172137255 @default.
• W2891096074 cites W2198390448 @default.
• W2891096074 cites W2276145920 @default.
• W2891096074 cites W2294987587 @default.
• W2891096074 cites W2513566524 @default.
• W2891096074 cites W2552950400 @default.
• W2891096074 cites W2584269700 @default.
• W2891096074 cites W2596217090 @default.
• W2891096074 cites W2609673557 @default.
• W2891096074 cites W2615387563 @default.
• W2891096074 cites W2615499841 @default.
• W2891096074 cites W2734562413 @default.
• W2891096074 cites W2751962976 @default.
• W2891096074 cites W2759678140 @default.
• W2891096074 cites W2803107654 @default.
• W2891096074 doi "https://doi.org/10.3389/fpsyt.2018.00417" @default.
• W2891096074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6132193" @default.
• W2891096074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30233433" @default.
• W2891096074 hasPublicationYear "2018" @default.
• W2891096074 type Work @default.
• W2891096074 sameAs 2891096074 @default.
• W2891096074 citedByCount "7" @default.
• W2891096074 countsByYear W28910960742019 @default.
• W2891096074 countsByYear W28910960742020 @default.
• W2891096074 countsByYear W28910960742021 @default.
• W2891096074 crossrefType "journal-article" @default.
• W2891096074 hasAuthorship W2891096074A5003391709 @default.
• W2891096074 hasAuthorship W2891096074A5022809900 @default.
• W2891096074 hasAuthorship W2891096074A5063118702 @default.
• W2891096074 hasAuthorship W2891096074A5083462165 @default.
• W2891096074 hasBestOaLocation W28910960741 @default.
• W2891096074 hasConcept C100136789 @default.
• W2891096074 hasConcept C120665830 @default.
• W2891096074 hasConcept C121332964 @default.
• W2891096074 hasConcept C126322002 @default.
• W2891096074 hasConcept C170493617 @default.
• W2891096074 hasConcept C177713679 @default.
• W2891096074 hasConcept C185592680 @default.
• W2891096074 hasConcept C2776376669 @default.
• W2891096074 hasConcept C2776860028 @default.
• W2891096074 hasConcept C2777495988 @default.
• W2891096074 hasConcept C2777953023 @default.
• W2891096074 hasConcept C2778938600 @default.
• W2891096074 hasConcept C2779442783 @default.
• W2891096074 hasConcept C2781066024 @default.
• W2891096074 hasConcept C2781201050 @default.
• W2891096074 hasConcept C42219234 @default.
• W2891096074 hasConcept C55493867 @default.
• W2891096074 hasConcept C71924100 @default.
• W2891096074 hasConcept C84393581 @default.
• W2891096074 hasConceptScore W2891096074C100136789 @default.
• W2891096074 hasConceptScore W2891096074C120665830 @default.
• W2891096074 hasConceptScore W2891096074C121332964 @default.
• W2891096074 hasConceptScore W2891096074C126322002 @default.
• W2891096074 hasConceptScore W2891096074C170493617 @default.
• W2891096074 hasConceptScore W2891096074C177713679 @default.
• W2891096074 hasConceptScore W2891096074C185592680 @default.
• W2891096074 hasConceptScore W2891096074C2776376669 @default.
• W2891096074 hasConceptScore W2891096074C2776860028 @default.
• W2891096074 hasConceptScore W2891096074C2777495988 @default.
• W2891096074 hasConceptScore W2891096074C2777953023 @default.
• W2891096074 hasConceptScore W2891096074C2778938600 @default.
• W2891096074 hasConceptScore W2891096074C2779442783 @default.
• W2891096074 hasConceptScore W2891096074C2781066024 @default.
• W2891096074 hasConceptScore W2891096074C2781201050 @default.
• W2891096074 hasConceptScore W2891096074C42219234 @default.
• W2891096074 hasConceptScore W2891096074C55493867 @default.
• W2891096074 hasConceptScore W2891096074C71924100 @default.

• next