Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891097004> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2891097004 abstract "Myostatin gene (MSTN) can inhibit the proliferation of myoblast, which in turn promotes muscle growth and inhibits adipocyte differentiation in livestock. MSTN mutation may lead to muscle hypertrophy or double-muscled (DM) phenotype. MSTN mutation animal, such as sheep, dog, and rabbit have been generated through CRISPR/Cas9 technology. However, goats with promising MSTN mutation have not been generated. We designed two sgRNAs loci targetting exon3 of MSTN gene to destroy the MSTN cysteines knots. We got seven goats from seven recipients, in which six were MSTN knocked-out (KO) goats, with a mutation rate of 85.7%. Destroyed cysteine knots caused MSTN structure inactivation. The average body weight gain (BWG) per day of MSTN KO goats was significantly higher than that of wild-type (WT) goats. MSTN KO goats showed abnormal sugar, fat, and protein metabolism compared with wild-type controls (MSTN+/+). Inheritance of mutations was observed in offspring of MSTN KO goats by PCR analysis." @default.
- W2891097004 created "2018-09-27" @default.
- W2891097004 creator A5009265926 @default.
- W2891097004 creator A5009507074 @default.
- W2891097004 creator A5012380108 @default.
- W2891097004 creator A5017879709 @default.
- W2891097004 creator A5042152019 @default.
- W2891097004 creator A5067742620 @default.
- W2891097004 creator A5088174174 @default.
- W2891097004 date "2018-11-14" @default.
- W2891097004 modified "2023-10-03" @default.
- W2891097004 title "Use of CRISPR/Cas9 technology efficiently targetted goat myostatin through zygotes microinjection resulting in double-muscled phenotype in goats" @default.
- W2891097004 cites W1577387537 @default.
- W2891097004 cites W1972641070 @default.
- W2891097004 cites W1974343902 @default.
- W2891097004 cites W1974626477 @default.
- W2891097004 cites W1982846895 @default.
- W2891097004 cites W1988075836 @default.
- W2891097004 cites W1995465696 @default.
- W2891097004 cites W2011968886 @default.
- W2891097004 cites W2051255304 @default.
- W2891097004 cites W2054368198 @default.
- W2891097004 cites W2056512830 @default.
- W2891097004 cites W2085993152 @default.
- W2891097004 cites W2096261947 @default.
- W2891097004 cites W2114796514 @default.
- W2891097004 cites W2130122556 @default.
- W2891097004 cites W2146923536 @default.
- W2891097004 cites W2224398381 @default.
- W2891097004 cites W2339045168 @default.
- W2891097004 cites W2344375869 @default.
- W2891097004 cites W2404457298 @default.
- W2891097004 cites W2562658921 @default.
- W2891097004 doi "https://doi.org/10.1042/bsr20180742" @default.
- W2891097004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6239268" @default.
- W2891097004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30201688" @default.
- W2891097004 hasPublicationYear "2018" @default.
- W2891097004 type Work @default.
- W2891097004 sameAs 2891097004 @default.
- W2891097004 citedByCount "47" @default.
- W2891097004 countsByYear W28910970042019 @default.
- W2891097004 countsByYear W28910970042020 @default.
- W2891097004 countsByYear W28910970042021 @default.
- W2891097004 countsByYear W28910970042022 @default.
- W2891097004 countsByYear W28910970042023 @default.
- W2891097004 crossrefType "journal-article" @default.
- W2891097004 hasAuthorship W2891097004A5009265926 @default.
- W2891097004 hasAuthorship W2891097004A5009507074 @default.
- W2891097004 hasAuthorship W2891097004A5012380108 @default.
- W2891097004 hasAuthorship W2891097004A5017879709 @default.
- W2891097004 hasAuthorship W2891097004A5042152019 @default.
- W2891097004 hasAuthorship W2891097004A5067742620 @default.
- W2891097004 hasAuthorship W2891097004A5088174174 @default.
- W2891097004 hasBestOaLocation W28910970041 @default.
- W2891097004 hasConcept C104317684 @default.
- W2891097004 hasConcept C127716648 @default.
- W2891097004 hasConcept C134018914 @default.
- W2891097004 hasConcept C153911025 @default.
- W2891097004 hasConcept C167414201 @default.
- W2891097004 hasConcept C2777488582 @default.
- W2891097004 hasConcept C501734568 @default.
- W2891097004 hasConcept C54355233 @default.
- W2891097004 hasConcept C86803240 @default.
- W2891097004 hasConcept C98108389 @default.
- W2891097004 hasConceptScore W2891097004C104317684 @default.
- W2891097004 hasConceptScore W2891097004C127716648 @default.
- W2891097004 hasConceptScore W2891097004C134018914 @default.
- W2891097004 hasConceptScore W2891097004C153911025 @default.
- W2891097004 hasConceptScore W2891097004C167414201 @default.
- W2891097004 hasConceptScore W2891097004C2777488582 @default.
- W2891097004 hasConceptScore W2891097004C501734568 @default.
- W2891097004 hasConceptScore W2891097004C54355233 @default.
- W2891097004 hasConceptScore W2891097004C86803240 @default.
- W2891097004 hasConceptScore W2891097004C98108389 @default.
- W2891097004 hasIssue "6" @default.
- W2891097004 hasLocation W28910970041 @default.
- W2891097004 hasLocation W28910970042 @default.
- W2891097004 hasLocation W28910970043 @default.
- W2891097004 hasLocation W28910970044 @default.
- W2891097004 hasOpenAccess W2891097004 @default.
- W2891097004 hasPrimaryLocation W28910970041 @default.
- W2891097004 hasRelatedWork W138964897 @default.
- W2891097004 hasRelatedWork W1530402712 @default.
- W2891097004 hasRelatedWork W2056833586 @default.
- W2891097004 hasRelatedWork W2077190448 @default.
- W2891097004 hasRelatedWork W2114796514 @default.
- W2891097004 hasRelatedWork W2143066563 @default.
- W2891097004 hasRelatedWork W2157166663 @default.
- W2891097004 hasRelatedWork W2764165019 @default.
- W2891097004 hasRelatedWork W2964199853 @default.
- W2891097004 hasRelatedWork W3179054707 @default.
- W2891097004 hasVolume "38" @default.
- W2891097004 isParatext "false" @default.
- W2891097004 isRetracted "false" @default.
- W2891097004 magId "2891097004" @default.
- W2891097004 workType "article" @default.