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- W2891097572 abstract "Gene transfer in haematopoietic stem cells is used in two ways : to investigate molecules involved in the regulation of haemotopoiesis, and to treat genetic disorders. In order to obtain the long-term expression of the transduced gene, required for both purposes, we must (1) reach rare primitive stem cells, with extensive capacities for proliferation and differentiation, (2) integrate the gene of interest in the genome of these cells and (3) maintain and control the expression of this gene during the in vivo differentiation of these cells. Retroviruses are, for the time being, the tools which best fulfil these requirements. However, the result obtained when they are used on large animals, including humans, are disappointing. Moreover, a number of studies shows the limited extent to which retroviruses transduce haematopoietic stem cells. They are restricted mainly by the requirements of cell cycle and virus receptor expression, but also by the difficulties of obtaining controlled gene expression. These limitations highlight the need for new vectors, cytokines or experimental models so that efficient, long-term, in vivo gene expression in normal haematopoietic cells can be achieved." @default.
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- W2891097572 date "1995-06-15" @default.
- W2891097572 modified "2023-10-18" @default.
- W2891097572 title "Gene transfer in haematopoietic stem cells" @default.
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