FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891097734> ?p ?o ?g. }

• W2891097734 endingPage "698" @default.
• W2891097734 startingPage "686" @default.
• W2891097734 abstract "Innate immune cells in different niches are differently affected by postprandial signals, which depend on the chyme composition. Postprandial signals are integrated at the bile acid (BA)–microbiome interface to differentially modulate the ability of innate immune cells to fight infections or sterile insults. The microbiome modulates BA signaling properties to potentiate their immune effects in the enterohepatic circulation. Reciprocally, BAs control microbiome growth and affect its ability to educate the immune system. The NLRP3 inflammasome is emerging as a central modulator of nutrition-induced inflammation. Nutrition metabolites imprint persistent changes on innate immune cell homeostasis, which might modulate their capacity to fight infections. Altered nutritional behavior in Western societies has unleashed numerous metabolic disorders, intimately linked to profound disruptions of the immune system. Here we summarize how nutrition modulates innate immunity. We outline recent findings regarding nutrient signaling and we particularly focus on the collateral impact of nutrition on the microbiome and on the bile acid (BA) pool. We discuss how the integration of postprandial signals by the gut microbiota, along with the absorption routes of metabolites, differentially affects immune niches to orchestrate immune responses. Finally, we discuss the potential consequences of these signals in the light of trained immunity. A better understanding of nutrition signaling will permit the optimization of therapeutic and dietary strategies against the arising immune disorders. Altered nutritional behavior in Western societies has unleashed numerous metabolic disorders, intimately linked to profound disruptions of the immune system. Here we summarize how nutrition modulates innate immunity. We outline recent findings regarding nutrient signaling and we particularly focus on the collateral impact of nutrition on the microbiome and on the bile acid (BA) pool. We discuss how the integration of postprandial signals by the gut microbiota, along with the absorption routes of metabolites, differentially affects immune niches to orchestrate immune responses. Finally, we discuss the potential consequences of these signals in the light of trained immunity. A better understanding of nutrition signaling will permit the optimization of therapeutic and dietary strategies against the arising immune disorders." @default.
• W2891097734 created "2018-09-27" @default.
• W2891097734 creator A5017294918 @default.
• W2891097734 creator A5028908166 @default.
• W2891097734 creator A5089314256 @default.
• W2891097734 date "2018-10-01" @default.
• W2891097734 modified "2023-10-02" @default.
• W2891097734 title "Nutritional Modulation of Innate Immunity: The Fat–Bile–Gut Connection" @default.
• W2891097734 cites W1515023627 @default.
• W2891097734 cites W1593760300 @default.
• W2891097734 cites W1636391291 @default.
• W2891097734 cites W1771440738 @default.
• W2891097734 cites W1910361842 @default.
• W2891097734 cites W1965707743 @default.
• W2891097734 cites W1966579300 @default.
• W2891097734 cites W1967056255 @default.
• W2891097734 cites W1977536320 @default.
• W2891097734 cites W1990305302 @default.
• W2891097734 cites W2002703043 @default.
• W2891097734 cites W2017362076 @default.
• W2891097734 cites W2017364473 @default.
• W2891097734 cites W2019676650 @default.
• W2891097734 cites W2022279737 @default.
• W2891097734 cites W2024183493 @default.
• W2891097734 cites W2048469790 @default.
• W2891097734 cites W2051303794 @default.
• W2891097734 cites W2059839808 @default.
• W2891097734 cites W2059861417 @default.
• W2891097734 cites W2067003464 @default.
• W2891097734 cites W2067401763 @default.
• W2891097734 cites W2067993711 @default.
• W2891097734 cites W2073247934 @default.
• W2891097734 cites W2075781716 @default.
• W2891097734 cites W2078599166 @default.
• W2891097734 cites W2081262717 @default.
• W2891097734 cites W2083260532 @default.
• W2891097734 cites W2085673449 @default.
• W2891097734 cites W2093009918 @default.
• W2891097734 cites W2094173870 @default.
• W2891097734 cites W2099604050 @default.
• W2891097734 cites W2099913817 @default.
• W2891097734 cites W2103703433 @default.
• W2891097734 cites W2104004584 @default.
• W2891097734 cites W2106069785 @default.
• W2891097734 cites W2107953386 @default.
• W2891097734 cites W2108733091 @default.
• W2891097734 cites W2109247985 @default.
• W2891097734 cites W2112671019 @default.
• W2891097734 cites W2116797415 @default.
• W2891097734 cites W2118918019 @default.
• W2891097734 cites W2119711390 @default.
• W2891097734 cites W2122292170 @default.
• W2891097734 cites W2124688365 @default.
• W2891097734 cites W2126811287 @default.
• W2891097734 cites W2129917444 @default.
• W2891097734 cites W2130896556 @default.
• W2891097734 cites W2132109696 @default.
• W2891097734 cites W2134897177 @default.
• W2891097734 cites W2134928825 @default.
• W2891097734 cites W2137211946 @default.
• W2891097734 cites W2138024339 @default.
• W2891097734 cites W2142179862 @default.
• W2891097734 cites W2143814738 @default.
• W2891097734 cites W2146805064 @default.
• W2891097734 cites W2148103005 @default.
• W2891097734 cites W2148345765 @default.
• W2891097734 cites W2149515881 @default.
• W2891097734 cites W2151335106 @default.
• W2891097734 cites W2156274620 @default.
• W2891097734 cites W2162778157 @default.
• W2891097734 cites W2165729840 @default.
• W2891097734 cites W2169078659 @default.
• W2891097734 cites W2170595651 @default.
• W2891097734 cites W2175465469 @default.
• W2891097734 cites W2184035191 @default.
• W2891097734 cites W2190117335 @default.
• W2891097734 cites W2201019342 @default.
• W2891097734 cites W2335821079 @default.
• W2891097734 cites W2341425007 @default.
• W2891097734 cites W2396518873 @default.
• W2891097734 cites W2412773516 @default.
• W2891097734 cites W2428595929 @default.
• W2891097734 cites W2467200611 @default.
• W2891097734 cites W2508233001 @default.
• W2891097734 cites W2510684933 @default.
• W2891097734 cites W2522715783 @default.
• W2891097734 cites W2523977787 @default.
• W2891097734 cites W2559354755 @default.
• W2891097734 cites W2560579106 @default.
• W2891097734 cites W2563363162 @default.
• W2891097734 cites W2578607799 @default.
• W2891097734 cites W2582309181 @default.
• W2891097734 cites W2585731231 @default.
• W2891097734 cites W2589672195 @default.
• W2891097734 cites W2596984373 @default.
• W2891097734 cites W2602758134 @default.
• W2891097734 cites W2613151721 @default.
• W2891097734 cites W2618592868 @default.

• next