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• W2891100690 endingPage "336" @default.
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• W2891100690 abstract "Human neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein present in a wide variety of tissues and cell types. NGAL exists as a 25 kDa monomer, a 46 kDa homodimer (the most abundant form in healthy subjects) and a 130 kDa disulfide-linked heterodimer bound to latent matrix metalloproteinase-9. Dysregulated expression of NGAL in human malignancies suggests its value as a clinical marker. A growing body of evidence is highlighting NGAL's paradoxical (i.e., both beneficial and detrimental) effects on cellular processes associated with tumor development (proliferation, survival, migration, invasion, and multidrug resistance). At least two distinct cell surface receptors are identified for NGAL. This review (i) summarizes our current knowledge of NGAL's expression profiles in solid tumors and leukemias, and (ii) critically evaluates the beneficial and detrimental activities of NGAL having been documented in a diverse range of cancer-derived cell lines. A better understanding of the causal relationships between NGAL dysregulation and tumor development will require a fine analysis of the molecular aspects and biological role(s) of NGAL both in primary tumors and at different stages of disease. Having an accurate picture of NGAL's contribution to tumor progression is a prerequisite for attempting to modulate this protein as a putative therapeutic target." @default.
• W2891100690 created "2018-09-27" @default.
• W2891100690 creator A5064064307 @default.
• W2891100690 creator A5070668456 @default.
• W2891100690 date "2018-09-18" @default.
• W2891100690 modified "2023-10-03" @default.
• W2891100690 title "Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?" @default.
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• W2891100690 doi "https://doi.org/10.3390/cancers10090336" @default.
• W2891100690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162539" @default.
• W2891100690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30231474" @default.
• W2891100690 hasPublicationYear "2018" @default.
• W2891100690 type Work @default.

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