Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891131877> ?p ?o ?g. }
- W2891131877 endingPage "296" @default.
- W2891131877 startingPage "283" @default.
- W2891131877 abstract "Depression is one of the most prevalent, recurrent and life-threatening mental illnesses. However, the precise mechanism underlying the disorder is not yet clearly understood. It is therefore, essential to identify the novel biomarkers which may help in the development of effective treatment.In this milieu, the profile of the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were considered as biomarkers in the light of pathophysiology of depression and its treatment.Previously, we have reported that BDNF level in the postmortem brain of suicide victims was significantly lower than those of normal controls. We also found decreased BDNF levels in the specific brain regions of the learned helplessness model of depression in rat, and was found to increase normal level following chronic fluoxetine hydrochloride treatment. NGF is another important member of neurotrophin, which is dysregulated in the pathophysiology of depression in some models of peripheral nerve damage and stress. The results shown evidences of the effect of antidepressants on modulating depression via the NGF in preclinical and clinical models of depression, but conflicted, therefore make it currently difficult to affirm the therapeutic role of antidepressants.Here, we review some of the preclinical and clinical studies aimed at disclosing the role of BDNF and NGF mediated pathophysiological mechanisms of depression and the new therapeutic approaches targeting those key molecules. In addition, an important link between BDNF, NGF and depression has been discussed in the light of current existing knowledge." @default.
- W2891131877 created "2018-09-27" @default.
- W2891131877 creator A5018920683 @default.
- W2891131877 creator A5070760178 @default.
- W2891131877 date "2018-11-27" @default.
- W2891131877 modified "2023-10-05" @default.
- W2891131877 title "Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment" @default.
- W2891131877 cites W1487628011 @default.
- W2891131877 cites W1593725384 @default.
- W2891131877 cites W1793700335 @default.
- W2891131877 cites W1963967066 @default.
- W2891131877 cites W1965596654 @default.
- W2891131877 cites W1966209805 @default.
- W2891131877 cites W1966589541 @default.
- W2891131877 cites W1969611389 @default.
- W2891131877 cites W1969713762 @default.
- W2891131877 cites W1972986786 @default.
- W2891131877 cites W1974065417 @default.
- W2891131877 cites W1974215491 @default.
- W2891131877 cites W1976070936 @default.
- W2891131877 cites W1979017394 @default.
- W2891131877 cites W1979668038 @default.
- W2891131877 cites W1980059968 @default.
- W2891131877 cites W1980166225 @default.
- W2891131877 cites W1980232800 @default.
- W2891131877 cites W1980854813 @default.
- W2891131877 cites W1983660540 @default.
- W2891131877 cites W1985978450 @default.
- W2891131877 cites W1987041766 @default.
- W2891131877 cites W1987947540 @default.
- W2891131877 cites W1989335928 @default.
- W2891131877 cites W1989944301 @default.
- W2891131877 cites W1990282352 @default.
- W2891131877 cites W1991576048 @default.
- W2891131877 cites W1993681982 @default.
- W2891131877 cites W1994140763 @default.
- W2891131877 cites W1994403951 @default.
- W2891131877 cites W1995290481 @default.
- W2891131877 cites W1996443737 @default.
- W2891131877 cites W1999476423 @default.
- W2891131877 cites W2001273234 @default.
- W2891131877 cites W2003008123 @default.
- W2891131877 cites W2003052375 @default.
- W2891131877 cites W2003117281 @default.
- W2891131877 cites W2006923280 @default.
- W2891131877 cites W2007401642 @default.
- W2891131877 cites W2007474550 @default.
- W2891131877 cites W2011189731 @default.
- W2891131877 cites W2012564256 @default.
- W2891131877 cites W2013168242 @default.
- W2891131877 cites W2013825587 @default.
- W2891131877 cites W2014256027 @default.
- W2891131877 cites W2014716170 @default.
- W2891131877 cites W2018815299 @default.
- W2891131877 cites W2020101444 @default.
- W2891131877 cites W2023343492 @default.
- W2891131877 cites W2025950603 @default.
- W2891131877 cites W2026906462 @default.
- W2891131877 cites W2026909610 @default.
- W2891131877 cites W2027101916 @default.
- W2891131877 cites W2029711073 @default.
- W2891131877 cites W2029803700 @default.
- W2891131877 cites W2030757244 @default.
- W2891131877 cites W2031358273 @default.
- W2891131877 cites W2031616890 @default.
- W2891131877 cites W2035399728 @default.
- W2891131877 cites W2035976682 @default.
- W2891131877 cites W2036840208 @default.
- W2891131877 cites W2037334463 @default.
- W2891131877 cites W2042085536 @default.
- W2891131877 cites W2042727575 @default.
- W2891131877 cites W2043283741 @default.
- W2891131877 cites W2044367029 @default.
- W2891131877 cites W2047796618 @default.
- W2891131877 cites W2051935955 @default.
- W2891131877 cites W2057953498 @default.
- W2891131877 cites W2058426031 @default.
- W2891131877 cites W2059189780 @default.
- W2891131877 cites W2059225833 @default.
- W2891131877 cites W2060495652 @default.
- W2891131877 cites W2064263166 @default.
- W2891131877 cites W2067350830 @default.
- W2891131877 cites W2074769745 @default.
- W2891131877 cites W2074833932 @default.
- W2891131877 cites W2074977784 @default.
- W2891131877 cites W2076589331 @default.
- W2891131877 cites W2076806893 @default.
- W2891131877 cites W2078740239 @default.
- W2891131877 cites W2080487891 @default.
- W2891131877 cites W2081624976 @default.
- W2891131877 cites W2082588922 @default.
- W2891131877 cites W2084706514 @default.
- W2891131877 cites W2086623210 @default.
- W2891131877 cites W2087090756 @default.
- W2891131877 cites W2088200315 @default.
- W2891131877 cites W2089198034 @default.
- W2891131877 cites W2089973274 @default.
- W2891131877 cites W2090280523 @default.