FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891133222> ?p ?o ?g. }

• W2891133222 endingPage "3416" @default.
• W2891133222 startingPage "3407" @default.
• W2891133222 abstract "Aim: Anti-VEGF therapy plays an important role in the treatment of malignant tumors, especially metastatic malignant tumors. However, resistance and an inefficient response to anti-VEGF therapy exist. The current study aimed to investigate whether autophagy plays a part in the anti-tumor effect of bevacizumab in colorectal cancer cells. Methods: VEGF-A expression was measured by immunohistochemical methods. Cell viability and cell apoptosis were detected using 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan (MTT) and flow cytometry. Autophagy was assessed by a western blot, fluorescence microscopy and transmission electron microscopy. HIF-1α was measured using a western blot. A xenograft tumor model of colorectal cancer was constructed to determine the efficacy of the treatment of bevacizumab and chloroquine. Results: VEGF-A protein was upregulated in colorectal cancer tissue. Anti-VEGF (bevacizumab) inhibited cell viability and induced apoptosis. Moreover, bevacizumab induced autophagy. The inhibition of autophagy by chloroquine or by small interfering RNA promoted bevacizumab-induced apoptosis and proliferation inhibition. Further study showed that bevacizumab treatment significantly augmented HIF-1α. Furthermore, cells pretreated with YC-1, a HIF-1α inhibitor, displayed significantly attenuated bevacizumab-induced autophagy. Finally, a combinatory treatment of bevacizumab and chloroquine synergistically inhibited tumor growth in a xenograft tumor model of colorectal cancer cells. Conclusions: Our results showed that the inhibition of autophagy promoted the anti-tumor effect of bevacizumab and may offer a promising therapeutic strategy for colorectal cancer." @default.
• W2891133222 created "2018-09-27" @default.
• W2891133222 creator A5003258955 @default.
• W2891133222 creator A5020363606 @default.
• W2891133222 creator A5020754736 @default.
• W2891133222 creator A5034654778 @default.
• W2891133222 creator A5048168253 @default.
• W2891133222 creator A5052248008 @default.
• W2891133222 date "2018-01-01" @default.
• W2891133222 modified "2023-10-16" @default.
• W2891133222 title "Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells" @default.
• W2891133222 cites W2025016054 @default.
• W2891133222 cites W2043809682 @default.
• W2891133222 cites W2055811314 @default.
• W2891133222 cites W2057420864 @default.
• W2891133222 cites W2079953288 @default.
• W2891133222 cites W2092583242 @default.
• W2891133222 cites W2098121718 @default.
• W2891133222 cites W2101399736 @default.
• W2891133222 cites W2126945850 @default.
• W2891133222 cites W2143852804 @default.
• W2891133222 cites W2161717621 @default.
• W2891133222 cites W2177430595 @default.
• W2891133222 cites W2265669783 @default.
• W2891133222 cites W2310478501 @default.
• W2891133222 cites W2419582720 @default.
• W2891133222 cites W2511078658 @default.
• W2891133222 cites W2741794924 @default.
• W2891133222 cites W2749693449 @default.
• W2891133222 cites W2752195019 @default.
• W2891133222 cites W2754385197 @default.
• W2891133222 cites W2754991740 @default.
• W2891133222 cites W2767216199 @default.
• W2891133222 cites W2768132193 @default.
• W2891133222 cites W2917837889 @default.
• W2891133222 cites W2974242035 @default.
• W2891133222 doi "https://doi.org/10.7150/jca.24201" @default.
• W2891133222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160673" @default.
• W2891133222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271503" @default.
• W2891133222 hasPublicationYear "2018" @default.
• W2891133222 type Work @default.
• W2891133222 sameAs 2891133222 @default.
• W2891133222 citedByCount "35" @default.
• W2891133222 countsByYear W28911332222019 @default.
• W2891133222 countsByYear W28911332222020 @default.
• W2891133222 countsByYear W28911332222021 @default.
• W2891133222 countsByYear W28911332222022 @default.
• W2891133222 countsByYear W28911332222023 @default.
• W2891133222 crossrefType "journal-article" @default.
• W2891133222 hasAuthorship W2891133222A5003258955 @default.
• W2891133222 hasAuthorship W2891133222A5020363606 @default.
• W2891133222 hasAuthorship W2891133222A5020754736 @default.
• W2891133222 hasAuthorship W2891133222A5034654778 @default.
• W2891133222 hasAuthorship W2891133222A5048168253 @default.
• W2891133222 hasAuthorship W2891133222A5052248008 @default.
• W2891133222 hasBestOaLocation W28911332221 @default.
• W2891133222 hasConcept C104317684 @default.
• W2891133222 hasConcept C121608353 @default.
• W2891133222 hasConcept C126322002 @default.
• W2891133222 hasConcept C127561419 @default.
• W2891133222 hasConcept C142724271 @default.
• W2891133222 hasConcept C185592680 @default.
• W2891133222 hasConcept C190283241 @default.
• W2891133222 hasConcept C203522944 @default.
• W2891133222 hasConcept C2776415932 @default.
• W2891133222 hasConcept C2776694085 @default.
• W2891133222 hasConcept C2777425658 @default.
• W2891133222 hasConcept C2777802072 @default.
• W2891133222 hasConcept C2778048844 @default.
• W2891133222 hasConcept C2779707156 @default.
• W2891133222 hasConcept C502942594 @default.
• W2891133222 hasConcept C526805850 @default.
• W2891133222 hasConcept C53227056 @default.
• W2891133222 hasConcept C55493867 @default.
• W2891133222 hasConcept C62112901 @default.
• W2891133222 hasConcept C71924100 @default.
• W2891133222 hasConcept C96232424 @default.
• W2891133222 hasConceptScore W2891133222C104317684 @default.
• W2891133222 hasConceptScore W2891133222C121608353 @default.
• W2891133222 hasConceptScore W2891133222C126322002 @default.
• W2891133222 hasConceptScore W2891133222C127561419 @default.
• W2891133222 hasConceptScore W2891133222C142724271 @default.
• W2891133222 hasConceptScore W2891133222C185592680 @default.
• W2891133222 hasConceptScore W2891133222C190283241 @default.
• W2891133222 hasConceptScore W2891133222C203522944 @default.
• W2891133222 hasConceptScore W2891133222C2776415932 @default.
• W2891133222 hasConceptScore W2891133222C2776694085 @default.
• W2891133222 hasConceptScore W2891133222C2777425658 @default.
• W2891133222 hasConceptScore W2891133222C2777802072 @default.
• W2891133222 hasConceptScore W2891133222C2778048844 @default.
• W2891133222 hasConceptScore W2891133222C2779707156 @default.
• W2891133222 hasConceptScore W2891133222C502942594 @default.
• W2891133222 hasConceptScore W2891133222C526805850 @default.
• W2891133222 hasConceptScore W2891133222C53227056 @default.
• W2891133222 hasConceptScore W2891133222C55493867 @default.
• W2891133222 hasConceptScore W2891133222C62112901 @default.
• W2891133222 hasConceptScore W2891133222C71924100 @default.
• W2891133222 hasConceptScore W2891133222C96232424 @default.

• next