Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891133335> ?p ?o ?g. }
- W2891133335 endingPage "6120" @default.
- W2891133335 startingPage "6107" @default.
- W2891133335 abstract "Abstract Dickkopf3 (DKK3) is a secretory protein that belongs to the DKK family, but exhibits structural divergence from other family members, and its corresponding receptors remain to be identified. Although DKK3 has been shown to have oncogenic functions in certain cancer types, the underlying mechanism by which DKK3 promotes tumorigenesis remains to be clarified. We show here that DKK3 stimulates esophageal cancer cell proliferation via cytoskeleton-associated protein 4 (CKAP4), which acts as a receptor for DKK3. DKK3 was expressed in approximately 50% of tumor lesions of esophageal squamous cell carcinoma (ESCC) cases; simultaneous expression of DKK3 and CKAP4 was associated with poor prognosis. Anti-CKAP4 antibody inhibited both binding of DKK3 to CKAP4 and xenograft tumor formation induced by ESCC cells. p63, a p53-related transcriptional factor frequently amplified in ESCC, bound to the upstream region of the DKK3 gene. Knockdown of p63 decreased DKK3 expression in ESCC cells, and reexpression of DKK3 partially rescued cell proliferation in p63-depleted ESCC cells. Expression of ΔNp63α and DKK3 increased the size of tumor-like esophageal organoids, and anti-CKAP4 antibody inhibited growth of esophageal organoids. Taken together, these results suggest that the DKK3-CKAP4 axis might serve as a novel molecular target for ESCC. Significance: In esophageal cancer, findings identify DKK3 as a poor prognostic indicator and demonstrate CKAP4 inhibition as an effective therapeutic strategy. Cancer Res; 78(21); 6107–20. ©2018 AACR." @default.
- W2891133335 created "2018-09-27" @default.
- W2891133335 creator A5017174755 @default.
- W2891133335 creator A5018442121 @default.
- W2891133335 creator A5028284770 @default.
- W2891133335 creator A5035190231 @default.
- W2891133335 creator A5036451745 @default.
- W2891133335 creator A5040891927 @default.
- W2891133335 creator A5046856618 @default.
- W2891133335 creator A5049747685 @default.
- W2891133335 creator A5061761883 @default.
- W2891133335 creator A5081009388 @default.
- W2891133335 creator A5088118861 @default.
- W2891133335 creator A5088956313 @default.
- W2891133335 date "2018-11-01" @default.
- W2891133335 modified "2023-10-05" @default.
- W2891133335 title "p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4" @default.
- W2891133335 cites W1515931733 @default.
- W2891133335 cites W1528865568 @default.
- W2891133335 cites W1589352523 @default.
- W2891133335 cites W1634699770 @default.
- W2891133335 cites W1757407923 @default.
- W2891133335 cites W1858379471 @default.
- W2891133335 cites W1920254011 @default.
- W2891133335 cites W1967073403 @default.
- W2891133335 cites W1970349562 @default.
- W2891133335 cites W1980814647 @default.
- W2891133335 cites W1990339803 @default.
- W2891133335 cites W1991528589 @default.
- W2891133335 cites W2001113336 @default.
- W2891133335 cites W2002513358 @default.
- W2891133335 cites W2006540657 @default.
- W2891133335 cites W2014938226 @default.
- W2891133335 cites W2024876545 @default.
- W2891133335 cites W2028955578 @default.
- W2891133335 cites W2042391568 @default.
- W2891133335 cites W2053387216 @default.
- W2891133335 cites W2055808176 @default.
- W2891133335 cites W2061377876 @default.
- W2891133335 cites W2062835218 @default.
- W2891133335 cites W2065081049 @default.
- W2891133335 cites W2081302775 @default.
- W2891133335 cites W2084275797 @default.
- W2891133335 cites W2115053373 @default.
- W2891133335 cites W2119226626 @default.
- W2891133335 cites W2147373137 @default.
- W2891133335 cites W2149377487 @default.
- W2891133335 cites W2165243775 @default.
- W2891133335 cites W2169373397 @default.
- W2891133335 cites W2441236057 @default.
- W2891133335 cites W2504314589 @default.
- W2891133335 cites W2513121575 @default.
- W2891133335 cites W2524820142 @default.
- W2891133335 cites W2570401594 @default.
- W2891133335 cites W2589343364 @default.
- W2891133335 cites W2590425124 @default.
- W2891133335 cites W2795895101 @default.
- W2891133335 cites W2800108104 @default.
- W2891133335 cites W4211048478 @default.
- W2891133335 doi "https://doi.org/10.1158/0008-5472.can-18-1749" @default.
- W2891133335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30181180" @default.
- W2891133335 hasPublicationYear "2018" @default.
- W2891133335 type Work @default.
- W2891133335 sameAs 2891133335 @default.
- W2891133335 citedByCount "29" @default.
- W2891133335 countsByYear W28911333352018 @default.
- W2891133335 countsByYear W28911333352019 @default.
- W2891133335 countsByYear W28911333352020 @default.
- W2891133335 countsByYear W28911333352021 @default.
- W2891133335 countsByYear W28911333352022 @default.
- W2891133335 countsByYear W28911333352023 @default.
- W2891133335 crossrefType "journal-article" @default.
- W2891133335 hasAuthorship W2891133335A5017174755 @default.
- W2891133335 hasAuthorship W2891133335A5018442121 @default.
- W2891133335 hasAuthorship W2891133335A5028284770 @default.
- W2891133335 hasAuthorship W2891133335A5035190231 @default.
- W2891133335 hasAuthorship W2891133335A5036451745 @default.
- W2891133335 hasAuthorship W2891133335A5040891927 @default.
- W2891133335 hasAuthorship W2891133335A5046856618 @default.
- W2891133335 hasAuthorship W2891133335A5049747685 @default.
- W2891133335 hasAuthorship W2891133335A5061761883 @default.
- W2891133335 hasAuthorship W2891133335A5081009388 @default.
- W2891133335 hasAuthorship W2891133335A5088118861 @default.
- W2891133335 hasAuthorship W2891133335A5088956313 @default.
- W2891133335 hasBestOaLocation W28911333351 @default.
- W2891133335 hasConcept C104317684 @default.
- W2891133335 hasConcept C121608353 @default.
- W2891133335 hasConcept C126322002 @default.
- W2891133335 hasConcept C127561419 @default.
- W2891133335 hasConcept C1491633281 @default.
- W2891133335 hasConcept C170493617 @default.
- W2891133335 hasConcept C173396325 @default.
- W2891133335 hasConcept C2779742542 @default.
- W2891133335 hasConcept C502942594 @default.
- W2891133335 hasConcept C54355233 @default.
- W2891133335 hasConcept C555283112 @default.
- W2891133335 hasConcept C62112901 @default.
- W2891133335 hasConcept C71924100 @default.