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- W2891137269 abstract "Abstract Aim Nijmegen breakage syndrome 1 (NBS1), also known as NBN, participates in cellular response to DNA damage and maintaining genomic stability. Functional polymorphisms located at a microRNA binding site in the 3′ UTR of NBS1 have been frequently studied in various cancers, but the results are inconsistent. The aim of the present study was to test a possible association between breast cancer risk and the NBS1 genetic variant, NBS1 rs2735383 541G > C, by performing a case–control study in an Iranian population. Materials & methods Allele-specific primer PCR method was utilized to genotype the genetic variant in 129 women with breast cancer and 117 healthy controls. The association tests with risk of breast cancer were examined by logistic regression. Results The NBS1 rs2735383 541G > C polymorphism was inversely associated with breast cancer (GC + CC vs GG, OR = 0.42, 95% C.I = 0.25–0.72, P value = 0.001; C vs G allele, OR = 0.43, 95% C.I = 0.29–0.62, P value Conclusion The rs2735383 variant may be a genetic modifier for breast cancer development in Iranians." @default.
- W2891137269 created "2018-09-27" @default.
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- W2891137269 date "2018-12-01" @default.
- W2891137269 modified "2023-09-23" @default.
- W2891137269 title "The miRNA binding site SNP in the 3′ UTR of NBS1 is inversely associated with breast cancer risk" @default.
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- W2891137269 doi "https://doi.org/10.1016/j.jocit.2018.09.013" @default.
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