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- W2891141728 endingPage "3848" @default.
- W2891141728 startingPage "3834" @default.
- W2891141728 abstract "Colorectal cancer (CRC) is often diagnosed at an advanced stage when tumor cell dissemination has taken place. Chemo- and targeted therapies provide only a limited increase of overall survival for these patients. The major reason for clinical outcome finds its origin in therapy resistance. Escape mechanisms to both chemo- and targeted therapy remain the main culprits. Here, we evaluate major resistant mechanisms and elaborate on potential new therapies. Amongst promising therapies is α-amanitin antibody-drug conjugate targeting hemizygous p53 loss. It becomes clear that a dynamic interaction with the tumor microenvironment exists and that this dictates therapeutic outcome. In addition, CRC displays a limited response to checkpoint inhibitors, as only a minority of patients with microsatellite instable high tumors is susceptible. In this review, we highlight new developments with clinical potentials to augment responses to checkpoint inhibitors." @default.
- W2891141728 created "2018-09-27" @default.
- W2891141728 creator A5004274922 @default.
- W2891141728 creator A5011006889 @default.
- W2891141728 creator A5019124641 @default.
- W2891141728 creator A5074045552 @default.
- W2891141728 creator A5087592041 @default.
- W2891141728 date "2018-09-14" @default.
- W2891141728 modified "2023-10-16" @default.
- W2891141728 title "Drug resistance and new therapies in colorectal cancer" @default.
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