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- W2891143935 abstract "Abstract The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant challenge. Herein, we report an artificially designed chiral-group-resetting biocatalytic process, which uses simple achiral glycine and aldehydes to synthesize stereodefined α-functionalized organic acids. This cascade biocatalysis comprises a basic module and three different extender modules and operates in a modular assembly manner. The engineered Escherichia coli catalysts, which contained different module(s), provide access to α-keto acids, α-hydroxy acids, and α-amino acids with excellent conversion and enantioselectivities. Therefore, this biocatalytic process provides an attractive strategy for the conversion of low-cost achiral starting materials to high-value α-functionalized organic acids." @default.
- W2891143935 created "2018-09-27" @default.
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- W2891143935 date "2018-09-19" @default.
- W2891143935 modified "2023-10-16" @default.
- W2891143935 title "Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process" @default.
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- W2891143935 doi "https://doi.org/10.1038/s41467-018-06241-x" @default.
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