Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891145174> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2891145174 endingPage "2080" @default.
- W2891145174 startingPage "2074" @default.
- W2891145174 abstract "Rationale Gallic acid is one of the most common polyphenols in natural products and human diet. The consumption of gallic acid reduces the incidence of cardiovascular diseases, chronic metabolic disorders and cancers. Most previous publications focused on the antioxidative or prooxidative properties of gallic acid. In the present work, gallic acid as a trapping agent of blood formaldehyde was investigated by liquid chromatography/tandem mass spectrometry (LC/MS/MS) and neutral loss scan. Methods Serum samples incubated with gallic acid were subjected to LC/MS/MS analysis using an LTQ XL ion trap mass spectrometer. The adduct ions of gallic acid‐formaldehyde‐amino acids were explored by investigation of their fragmentation patterns and neutral loss scan experiments. Results A series of Mannich adducts (namely, gallic acid‐formaldehyde‐alanine, gallic acid‐formaldehyde‐proline, gallic acid‐formaldehyde‐leucine or gallic acid‐formaldehyde‐isoleucine and gallic acid‐formaldehyde‐phenylalanine) were identified as metabolites by neutral loss scan experiments. Conclusions This work demonstrated that serum amino acids are involved in gallic acid detoxification of formaldehyde. Because excessive formaldehyde in blood is implicated in a variety of disease pathologies, detoxification of formaldehyde, especially endogenous formaldehyde, may be another health beneficial effect of gallic acid. It also suggested that more attention should be paid to Mannich‐type metabolites of polyphenol‐formaldehyde‐amino acids in research into the pharmacokinetics and bioavailability of polyphenols." @default.
- W2891145174 created "2018-09-27" @default.
- W2891145174 creator A5002734224 @default.
- W2891145174 creator A5005215881 @default.
- W2891145174 creator A5007108042 @default.
- W2891145174 creator A5037365557 @default.
- W2891145174 creator A5056372442 @default.
- W2891145174 date "2018-11-05" @default.
- W2891145174 modified "2023-10-05" @default.
- W2891145174 title "Investigation of serum amino acids involved in gallic acid detoxification of formaldehyde by liquid chromatography/tandem mass spectrometry and neutral loss scan" @default.
- W2891145174 cites W1500121101 @default.
- W2891145174 cites W1964161751 @default.
- W2891145174 cites W1965668642 @default.
- W2891145174 cites W1977033351 @default.
- W2891145174 cites W1997259826 @default.
- W2891145174 cites W2000967440 @default.
- W2891145174 cites W2005775144 @default.
- W2891145174 cites W2007324558 @default.
- W2891145174 cites W2008941833 @default.
- W2891145174 cites W2019981961 @default.
- W2891145174 cites W2022094467 @default.
- W2891145174 cites W2025458587 @default.
- W2891145174 cites W2052267827 @default.
- W2891145174 cites W2053058287 @default.
- W2891145174 cites W2058924723 @default.
- W2891145174 cites W2062980660 @default.
- W2891145174 cites W2076681293 @default.
- W2891145174 cites W2078025007 @default.
- W2891145174 cites W2091099722 @default.
- W2891145174 cites W2103921650 @default.
- W2891145174 cites W2110620500 @default.
- W2891145174 cites W2117154880 @default.
- W2891145174 cites W2137998583 @default.
- W2891145174 cites W2141270060 @default.
- W2891145174 cites W2166129369 @default.
- W2891145174 cites W2168389275 @default.
- W2891145174 cites W2748677962 @default.
- W2891145174 cites W3192942089 @default.
- W2891145174 doi "https://doi.org/10.1002/rcm.8278" @default.
- W2891145174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192419" @default.
- W2891145174 hasPublicationYear "2018" @default.
- W2891145174 type Work @default.
- W2891145174 sameAs 2891145174 @default.
- W2891145174 citedByCount "7" @default.
- W2891145174 countsByYear W28911451742020 @default.
- W2891145174 countsByYear W28911451742021 @default.
- W2891145174 countsByYear W28911451742022 @default.
- W2891145174 crossrefType "journal-article" @default.
- W2891145174 hasAuthorship W2891145174A5002734224 @default.
- W2891145174 hasAuthorship W2891145174A5005215881 @default.
- W2891145174 hasAuthorship W2891145174A5007108042 @default.
- W2891145174 hasAuthorship W2891145174A5037365557 @default.
- W2891145174 hasAuthorship W2891145174A5056372442 @default.
- W2891145174 hasConcept C178790620 @default.
- W2891145174 hasConcept C185592680 @default.
- W2891145174 hasConcept C2775930285 @default.
- W2891145174 hasConcept C2778004101 @default.
- W2891145174 hasConcept C2778362808 @default.
- W2891145174 hasConcept C43617362 @default.
- W2891145174 hasConcept C70899900 @default.
- W2891145174 hasConceptScore W2891145174C178790620 @default.
- W2891145174 hasConceptScore W2891145174C185592680 @default.
- W2891145174 hasConceptScore W2891145174C2775930285 @default.
- W2891145174 hasConceptScore W2891145174C2778004101 @default.
- W2891145174 hasConceptScore W2891145174C2778362808 @default.
- W2891145174 hasConceptScore W2891145174C43617362 @default.
- W2891145174 hasConceptScore W2891145174C70899900 @default.
- W2891145174 hasFunder F4320321001 @default.
- W2891145174 hasFunder F4320322186 @default.
- W2891145174 hasIssue "23" @default.
- W2891145174 hasLocation W28911451741 @default.
- W2891145174 hasLocation W28911451742 @default.
- W2891145174 hasOpenAccess W2891145174 @default.
- W2891145174 hasPrimaryLocation W28911451741 @default.
- W2891145174 hasRelatedWork W1979792674 @default.
- W2891145174 hasRelatedWork W1986974960 @default.
- W2891145174 hasRelatedWork W2043757586 @default.
- W2891145174 hasRelatedWork W2075700590 @default.
- W2891145174 hasRelatedWork W2361320231 @default.
- W2891145174 hasRelatedWork W2372639119 @default.
- W2891145174 hasRelatedWork W2386973156 @default.
- W2891145174 hasRelatedWork W2388425693 @default.
- W2891145174 hasRelatedWork W2993601615 @default.
- W2891145174 hasRelatedWork W4200212353 @default.
- W2891145174 hasVolume "32" @default.
- W2891145174 isParatext "false" @default.
- W2891145174 isRetracted "false" @default.
- W2891145174 magId "2891145174" @default.
- W2891145174 workType "article" @default.