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- W2891146089 abstract "Human transplant programs provide significant opportunities for detailed in vitro assessments of physiological properties of selected tissues and cell types. We present a semi-quantitative study of the fundamental electrophysiological/biophysical characteristics of human chondrocytes, focused on K+ transport mechanisms, and their ability to regulate to the resting membrane potential, Em. Patch clamp studies on these enzymatically isolated human chondrocytes reveal consistent expression of at least three functionally distinct K+ currents, as well as transient receptor potential (TRP) currents. The small size of these cells and their exceptionally low current densities present significant technical challenges for electrophysiological recordings. These limitations have been addressed by parallel development of a mathematical model of these K+ and TRP channel ion transfer mechanisms in an attempt to reveal their contributions to Em. In combination, these experimental results and simulations yield new insights into: (i) the ionic basis for Em and its expected range of values; (ii) modulation of Em by the unique articular joint extracellular milieu; (iii) some aspects of TRP channel mediated depolarization-secretion coupling; (iv) some of the essential biophysical principles that regulate K+ channel function in chondrons. The chondron denotes the chondrocyte and its immediate extracellular compartment. The presence of discrete localized surface charges and associated zeta potentials at the chondrocyte surface are regulated by cell metabolism and can modulate interactions of chondrocytes with the extracellular matrix. Semi-quantitative analysis of these factors in chondrocyte/chondron function may yield insights into progressive osteoarthritis." @default.
- W2891146089 created "2018-09-27" @default.
- W2891146089 creator A5035987989 @default.
- W2891146089 creator A5074951070 @default.
- W2891146089 creator A5088661165 @default.
- W2891146089 creator A5088846739 @default.
- W2891146089 date "2018-09-04" @default.
- W2891146089 modified "2023-09-25" @default.
- W2891146089 title "The Resting Potential and K+ Currents in Primary Human Articular Chondrocytes" @default.
- W2891146089 cites W1497710305 @default.
- W2891146089 cites W1511142374 @default.
- W2891146089 cites W1554446171 @default.
- W2891146089 cites W1571837352 @default.
- W2891146089 cites W1599277155 @default.
- W2891146089 cites W1782148244 @default.
- W2891146089 cites W1833069420 @default.
- W2891146089 cites W1907180716 @default.
- W2891146089 cites W1957956713 @default.
- W2891146089 cites W1963817121 @default.
- W2891146089 cites W1963957029 @default.
- W2891146089 cites W1964355805 @default.
- W2891146089 cites W1965130745 @default.
- W2891146089 cites W1966138593 @default.
- W2891146089 cites W1968222832 @default.
- W2891146089 cites W1968649940 @default.
- W2891146089 cites W1969983111 @default.
- W2891146089 cites W1970889097 @default.
- W2891146089 cites W1971084572 @default.
- W2891146089 cites W1978353860 @default.
- W2891146089 cites W1982818212 @default.
- W2891146089 cites W1984968609 @default.
- W2891146089 cites W1993637697 @default.
- W2891146089 cites W1995857138 @default.
- W2891146089 cites W1995986197 @default.
- W2891146089 cites W2001518745 @default.
- W2891146089 cites W2001835147 @default.
- W2891146089 cites W2003331951 @default.
- W2891146089 cites W2009524387 @default.
- W2891146089 cites W2010240830 @default.
- W2891146089 cites W2010356581 @default.
- W2891146089 cites W2010909603 @default.
- W2891146089 cites W2015426350 @default.
- W2891146089 cites W2017435196 @default.
- W2891146089 cites W2017612052 @default.
- W2891146089 cites W2019889136 @default.
- W2891146089 cites W2022721848 @default.
- W2891146089 cites W2023683301 @default.
- W2891146089 cites W2024227894 @default.
- W2891146089 cites W2031574073 @default.
- W2891146089 cites W2033448044 @default.
- W2891146089 cites W2035058713 @default.
- W2891146089 cites W2036145275 @default.
- W2891146089 cites W2037758567 @default.
- W2891146089 cites W2042837372 @default.
- W2891146089 cites W2044474278 @default.
- W2891146089 cites W2044995040 @default.
- W2891146089 cites W2046185478 @default.
- W2891146089 cites W2048492290 @default.
- W2891146089 cites W2052958922 @default.
- W2891146089 cites W2053972873 @default.
- W2891146089 cites W2058067342 @default.
- W2891146089 cites W2060667756 @default.
- W2891146089 cites W2061086397 @default.
- W2891146089 cites W2061197019 @default.
- W2891146089 cites W2061867428 @default.
- W2891146089 cites W2062490687 @default.
- W2891146089 cites W2064315285 @default.
- W2891146089 cites W2064971284 @default.
- W2891146089 cites W2070522393 @default.
- W2891146089 cites W2071236789 @default.
- W2891146089 cites W2072081603 @default.
- W2891146089 cites W2072305464 @default.
- W2891146089 cites W2072427493 @default.
- W2891146089 cites W2074875891 @default.
- W2891146089 cites W2074910365 @default.
- W2891146089 cites W2075857412 @default.
- W2891146089 cites W2076259409 @default.
- W2891146089 cites W2077691483 @default.
- W2891146089 cites W2079357592 @default.
- W2891146089 cites W2080535356 @default.
- W2891146089 cites W2083546827 @default.
- W2891146089 cites W2086898489 @default.
- W2891146089 cites W2088824573 @default.
- W2891146089 cites W2090183574 @default.
- W2891146089 cites W2091444368 @default.
- W2891146089 cites W2091564611 @default.
- W2891146089 cites W2093970951 @default.
- W2891146089 cites W2094931111 @default.
- W2891146089 cites W2101009102 @default.
- W2891146089 cites W2101093856 @default.
- W2891146089 cites W2101235551 @default.
- W2891146089 cites W2104325257 @default.
- W2891146089 cites W2106826179 @default.
- W2891146089 cites W2109133991 @default.
- W2891146089 cites W2111787849 @default.
- W2891146089 cites W2118450542 @default.
- W2891146089 cites W2122883560 @default.
- W2891146089 cites W2124906522 @default.
- W2891146089 cites W2127748321 @default.
- W2891146089 cites W2137626687 @default.