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- W2891159778 abstract "Detecting disease-related biomarkers is of great significance for disease diagnosis and therapy. In this work, we develop an ultrasensitive surface-enhanced Raman scattering (SERS) biosensor for the detection of an acute myocardial infarction-related miRNA (miR-133a) using composition-adjustable hollow Ag/Au nanosphere-based SERS probes coupled with the target-catalyzed hairpin assembly (CHA) strategy. Bimetallic probes displaying high stability and a strong surface plasmon resonance effect were synthesized with a controllable ratio of silver and gold by a galvanic replacement method and then captured by a duplex linker produced in the CHA process to accomplish signal amplification. In this way, the target miR-133a can be detected in a wide linear range with a detection limit of 0.306 fM and high selectivity over other miRNAs expressed in human hearts. Practical applications in human blood samples reveal the strong anti-interference ability and ideal sensitivity of our developed sensing platform in physiological environments, benefiting its potential biomedical applications." @default.
- W2891159778 created "2018-09-27" @default.
- W2891159778 creator A5010278187 @default.
- W2891159778 creator A5066668521 @default.
- W2891159778 date "2018-09-03" @default.
- W2891159778 modified "2023-09-26" @default.
- W2891159778 title "Composition-Tunable Hollow Au/Ag SERS Nanoprobes Coupled with Target-Catalyzed Hairpin Assembly for Triple-Amplification Detection of miRNA" @default.
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- W2891159778 doi "https://doi.org/10.1021/acs.analchem.8b03067" @default.
- W2891159778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175580" @default.
- W2891159778 hasPublicationYear "2018" @default.
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