FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891160189> ?p ?o ?g. }

• W2891160189 endingPage "e13841" @default.
• W2891160189 startingPage "e13841" @default.
• W2891160189 abstract "Gαi2 , a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis. Platelet-expressed Gαi2 is decisive for the extent of tissue injury following ischemia/reperfusion. However, it is not known whether Gαi2 plays a role in the regulation of platelet apoptosis, which is characterized by caspase activation, cell shrinkage and cell membrane scrambling with phosphatidylserine (PS) translocation to the platelet surface. Stimulators of platelet apoptosis include thrombin and collagen-related peptide (CoRP), which are further known to enhance degranulation and activation of αIIb β3-integrin and caspases. Using FACS analysis, we examined the impact of agonist treatment on activation and apoptosis in platelets drawn from mice lacking Gαi2 and their wild-type (WT) littermates. As a result, treatment with either thrombin (0.01 U/mL) or CoRP (2 μg/mL or 5 μg/mL) significantly upregulated PS-exposure and significantly decreased forward scatter, reflecting cell size, in both genotypes. Exposure to CoRP triggered a significant increase in active caspase 3, ceramide formation, surface P-selectin, and αIIb β3-integrin activation. These molecular alterations were significantly less pronounced in Gαi2 -deficient platelets as compared to WT platelets. In conclusion, our data highlight a previously unreported role of Gαi2 signaling in governing platelet activation and apoptosis." @default.
• W2891160189 created "2018-09-27" @default.
• W2891160189 creator A5003363567 @default.
• W2891160189 creator A5004091570 @default.
• W2891160189 creator A5009905903 @default.
• W2891160189 creator A5015579866 @default.
• W2891160189 creator A5017428199 @default.
• W2891160189 creator A5028000508 @default.
• W2891160189 creator A5041020502 @default.
• W2891160189 creator A5058897031 @default.
• W2891160189 creator A5065486769 @default.
• W2891160189 creator A5070142597 @default.
• W2891160189 creator A5071468401 @default.
• W2891160189 creator A5079002169 @default.
• W2891160189 creator A5084208566 @default.
• W2891160189 date "2018-09-01" @default.
• W2891160189 modified "2023-10-05" @default.
• W2891160189 title "Heterotrimeric G-protein subunit G<i>α</i> _i2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets" @default.
• W2891160189 cites W1622902362 @default.
• W2891160189 cites W1971529415 @default.
• W2891160189 cites W1992093159 @default.
• W2891160189 cites W1995483578 @default.
• W2891160189 cites W2010231461 @default.
• W2891160189 cites W2012528572 @default.
• W2891160189 cites W2021332790 @default.
• W2891160189 cites W2028060910 @default.
• W2891160189 cites W2042549542 @default.
• W2891160189 cites W2079139403 @default.
• W2891160189 cites W2143727368 @default.
• W2891160189 cites W2161488081 @default.
• W2891160189 cites W2176268439 @default.
• W2891160189 cites W2284864531 @default.
• W2891160189 cites W2341698350 @default.
• W2891160189 cites W2483692171 @default.
• W2891160189 cites W2765734507 @default.
• W2891160189 cites W2777807685 @default.
• W2891160189 cites W2790752610 @default.
• W2891160189 cites W2794075611 @default.
• W2891160189 cites W2806782218 @default.
• W2891160189 cites W2891160189 @default.
• W2891160189 doi "https://doi.org/10.14814/phy2.13841" @default.
• W2891160189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125243" @default.
• W2891160189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30187671" @default.
• W2891160189 hasPublicationYear "2018" @default.
• W2891160189 type Work @default.
• W2891160189 sameAs 2891160189 @default.
• W2891160189 citedByCount "6" @default.
• W2891160189 countsByYear W28911601892019 @default.
• W2891160189 countsByYear W28911601892020 @default.
• W2891160189 countsByYear W28911601892022 @default.
• W2891160189 countsByYear W28911601892023 @default.
• W2891160189 crossrefType "journal-article" @default.
• W2891160189 hasAuthorship W2891160189A5003363567 @default.
• W2891160189 hasAuthorship W2891160189A5004091570 @default.
• W2891160189 hasAuthorship W2891160189A5009905903 @default.
• W2891160189 hasAuthorship W2891160189A5015579866 @default.
• W2891160189 hasAuthorship W2891160189A5017428199 @default.
• W2891160189 hasAuthorship W2891160189A5028000508 @default.
• W2891160189 hasAuthorship W2891160189A5041020502 @default.
• W2891160189 hasAuthorship W2891160189A5058897031 @default.
• W2891160189 hasAuthorship W2891160189A5065486769 @default.
• W2891160189 hasAuthorship W2891160189A5070142597 @default.
• W2891160189 hasAuthorship W2891160189A5071468401 @default.
• W2891160189 hasAuthorship W2891160189A5079002169 @default.
• W2891160189 hasAuthorship W2891160189A5084208566 @default.
• W2891160189 hasBestOaLocation W28911601891 @default.
• W2891160189 hasConcept C139407321 @default.
• W2891160189 hasConcept C153911025 @default.
• W2891160189 hasConcept C170493617 @default.
• W2891160189 hasConcept C185592680 @default.
• W2891160189 hasConcept C190283241 @default.
• W2891160189 hasConcept C203014093 @default.
• W2891160189 hasConcept C2777292125 @default.
• W2891160189 hasConcept C3018697912 @default.
• W2891160189 hasConcept C49802076 @default.
• W2891160189 hasConcept C55493867 @default.
• W2891160189 hasConcept C62478195 @default.
• W2891160189 hasConcept C80631254 @default.
• W2891160189 hasConcept C86803240 @default.
• W2891160189 hasConcept C89560881 @default.
• W2891160189 hasConcept C95444343 @default.
• W2891160189 hasConceptScore W2891160189C139407321 @default.
• W2891160189 hasConceptScore W2891160189C153911025 @default.
• W2891160189 hasConceptScore W2891160189C170493617 @default.
• W2891160189 hasConceptScore W2891160189C185592680 @default.
• W2891160189 hasConceptScore W2891160189C190283241 @default.
• W2891160189 hasConceptScore W2891160189C203014093 @default.
• W2891160189 hasConceptScore W2891160189C2777292125 @default.
• W2891160189 hasConceptScore W2891160189C3018697912 @default.
• W2891160189 hasConceptScore W2891160189C49802076 @default.
• W2891160189 hasConceptScore W2891160189C55493867 @default.
• W2891160189 hasConceptScore W2891160189C62478195 @default.
• W2891160189 hasConceptScore W2891160189C80631254 @default.
• W2891160189 hasConceptScore W2891160189C86803240 @default.
• W2891160189 hasConceptScore W2891160189C89560881 @default.
• W2891160189 hasConceptScore W2891160189C95444343 @default.
• W2891160189 hasFunder F4320320879 @default.
• W2891160189 hasFunder F4320332161 @default.

• next