FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891163929> ?p ?o ?g. }

• W2891163929 endingPage "44" @default.
• W2891163929 startingPage "38" @default.
• W2891163929 abstract "The unchecked tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. Therefore, this oncogene is a highly important therapeutic target for chronic myelogenous leukaemia (CML). Tyrosine kinase inhibitors (TKIs) are an excellent drug treatment for CML patients. However, there are still some patients who are not responsive to TKIs. We found that a novel circular RNA (circRNA), named circBA9.3, is derived from BCR-ABL1. CircBA9.3 can efficiently promote the proliferation and inhibit apoptosis of cancer cells. In addition, some patients with TKI resistance have elevated circBA9.3 expression, which is positively correlated with the level of BCR-ABL1. Furthermore, circBA9.3 is predominantly located in the cytoplasm and enhances c-ABL1 and BCR-ABL1 oncoprotein expression. Thus, circBA9.3 is a molecule associated with increased tyrosine kinase activity that promotes resistance against TKI therapy. In this study, we provided a new potential target for the treatment of TKI-resistant CML patients." @default.
• W2891163929 created "2018-09-27" @default.
• W2891163929 creator A5000409700 @default.
• W2891163929 creator A5003787100 @default.
• W2891163929 creator A5033600820 @default.
• W2891163929 creator A5043567666 @default.
• W2891163929 creator A5061664113 @default.
• W2891163929 creator A5078632164 @default.
• W2891163929 creator A5087152928 @default.
• W2891163929 date "2018-11-01" @default.
• W2891163929 modified "2023-09-29" @default.
• W2891163929 title "CircBA9.3 supports the survival of leukaemic cells by up-regulating c-ABL1 or BCR-ABL1 protein levels" @default.
• W2891163929 cites W1032731786 @default.
• W2891163929 cites W1525555980 @default.
• W2891163929 cites W1966411071 @default.
• W2891163929 cites W1967770261 @default.
• W2891163929 cites W1968747503 @default.
• W2891163929 cites W1977214653 @default.
• W2891163929 cites W1994830891 @default.
• W2891163929 cites W1997730029 @default.
• W2891163929 cites W2016656445 @default.
• W2891163929 cites W2016809033 @default.
• W2891163929 cites W2017919052 @default.
• W2891163929 cites W2050904392 @default.
• W2891163929 cites W2057375535 @default.
• W2891163929 cites W2058835062 @default.
• W2891163929 cites W2064165694 @default.
• W2891163929 cites W2080090818 @default.
• W2891163929 cites W2088137428 @default.
• W2891163929 cites W2101217932 @default.
• W2891163929 cites W2107268345 @default.
• W2891163929 cites W2112158339 @default.
• W2891163929 cites W2264241115 @default.
• W2891163929 cites W2266356262 @default.
• W2891163929 cites W2318224129 @default.
• W2891163929 cites W2323385078 @default.
• W2891163929 cites W2398047035 @default.
• W2891163929 cites W2410092046 @default.
• W2891163929 cites W2511152819 @default.
• W2891163929 cites W2557141539 @default.
• W2891163929 cites W2560091712 @default.
• W2891163929 cites W2592060299 @default.
• W2891163929 cites W2594477541 @default.
• W2891163929 cites W2624817122 @default.
• W2891163929 cites W2744268790 @default.
• W2891163929 cites W2750206713 @default.
• W2891163929 cites W2762869808 @default.
• W2891163929 cites W2769946661 @default.
• W2891163929 cites W2798204307 @default.
• W2891163929 cites W3113125785 @default.
• W2891163929 cites W4238038536 @default.
• W2891163929 doi "https://doi.org/10.1016/j.bcmd.2018.09.002" @default.
• W2891163929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30224298" @default.
• W2891163929 hasPublicationYear "2018" @default.
• W2891163929 type Work @default.
• W2891163929 sameAs 2891163929 @default.
• W2891163929 citedByCount "47" @default.
• W2891163929 countsByYear W28911639292019 @default.
• W2891163929 countsByYear W28911639292020 @default.
• W2891163929 countsByYear W28911639292021 @default.
• W2891163929 countsByYear W28911639292022 @default.
• W2891163929 countsByYear W28911639292023 @default.
• W2891163929 crossrefType "journal-article" @default.
• W2891163929 hasAuthorship W2891163929A5000409700 @default.
• W2891163929 hasAuthorship W2891163929A5003787100 @default.
• W2891163929 hasAuthorship W2891163929A5033600820 @default.
• W2891163929 hasAuthorship W2891163929A5043567666 @default.
• W2891163929 hasAuthorship W2891163929A5061664113 @default.
• W2891163929 hasAuthorship W2891163929A5078632164 @default.
• W2891163929 hasAuthorship W2891163929A5087152928 @default.
• W2891163929 hasConcept C121608353 @default.
• W2891163929 hasConcept C125418893 @default.
• W2891163929 hasConcept C126322002 @default.
• W2891163929 hasConcept C170493617 @default.
• W2891163929 hasConcept C184235292 @default.
• W2891163929 hasConcept C203014093 @default.
• W2891163929 hasConcept C2776960273 @default.
• W2891163929 hasConcept C2777583451 @default.
• W2891163929 hasConcept C2778461978 @default.
• W2891163929 hasConcept C2778729363 @default.
• W2891163929 hasConcept C2778820342 @default.
• W2891163929 hasConcept C2781018059 @default.
• W2891163929 hasConcept C29537977 @default.
• W2891163929 hasConcept C42362537 @default.
• W2891163929 hasConcept C43907098 @default.
• W2891163929 hasConcept C502942594 @default.
• W2891163929 hasConcept C62478195 @default.
• W2891163929 hasConcept C71924100 @default.
• W2891163929 hasConcept C86803240 @default.
• W2891163929 hasConcept C95444343 @default.
• W2891163929 hasConceptScore W2891163929C121608353 @default.
• W2891163929 hasConceptScore W2891163929C125418893 @default.
• W2891163929 hasConceptScore W2891163929C126322002 @default.
• W2891163929 hasConceptScore W2891163929C170493617 @default.
• W2891163929 hasConceptScore W2891163929C184235292 @default.
• W2891163929 hasConceptScore W2891163929C203014093 @default.
• W2891163929 hasConceptScore W2891163929C2776960273 @default.
• W2891163929 hasConceptScore W2891163929C2777583451 @default.

• next