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- W2891163989 abstract "The ApcMin/+ mouse, carrying an inactivated allele of the adenomatous polyposis coli (Apc) gene, is a widely used animal model of human colorectal tumorigenesis. While crossed with other gene knockout or knock-in mice, these mice possess advantages in investigation of human intestinal tumorigenesis. Intestinal tumor pathogenesis involves multiple gene alterations; thus, various double gene deficiency models could provide novel insights into molecular mechanisms of tumor biology, as well as gene-gene interactions involved in intestinal tumor development and assessment of novel strategies for preventing and treating intestinal cancer. This review discusses approximately 100 double gene deficient mice and their associated intestinal tumor development and progression phenotypes. The dual gene knockouts based on the Apc mutation background consist of inflammation and immune-related, cell cycle-related, Wnt/β-catenin signaling-related, tumor growth factor (TGF)-signaling-related, drug metabolism-related, and transcription factor genes, as well as some oncogenes and tumor suppressors. Future studies should focus on conditional or inducible dual or multiple mouse gene knockout models to investigate the molecular mechanisms underlying intestinal tumor development, as well as potential drug targets." @default.
- W2891163989 created "2018-09-27" @default.
- W2891163989 creator A5012720957 @default.
- W2891163989 creator A5029484872 @default.
- W2891163989 creator A5046225712 @default.
- W2891163989 creator A5052931336 @default.
- W2891163989 date "2018-12-01" @default.
- W2891163989 modified "2023-09-27" @default.
- W2891163989 title "Dual gene deficient models of ApcMin/+ mouse in assessing molecular mechanisms of intestinal carcinogenesis" @default.
- W2891163989 cites W1455592191 @default.
- W2891163989 cites W1483245334 @default.
- W2891163989 cites W1487572239 @default.
- W2891163989 cites W1533904499 @default.
- W2891163989 cites W1569974486 @default.
- W2891163989 cites W1592051611 @default.
- W2891163989 cites W162614240 @default.
- W2891163989 cites W1659749843 @default.
- W2891163989 cites W1750666972 @default.
- W2891163989 cites W1820742834 @default.
- W2891163989 cites W1839349418 @default.
- W2891163989 cites W1963941229 @default.
- W2891163989 cites W1967243795 @default.
- W2891163989 cites W1967337834 @default.
- W2891163989 cites W1971633665 @default.
- W2891163989 cites W1971644781 @default.
- W2891163989 cites W1971716536 @default.
- W2891163989 cites W1971850308 @default.
- W2891163989 cites W1971967608 @default.
- W2891163989 cites W1972291791 @default.
- W2891163989 cites W1973056955 @default.
- W2891163989 cites W1979081816 @default.
- W2891163989 cites W1979898922 @default.
- W2891163989 cites W1984576980 @default.
- W2891163989 cites W1985671514 @default.
- W2891163989 cites W1986367356 @default.
- W2891163989 cites W1986396469 @default.
- W2891163989 cites W1988399759 @default.
- W2891163989 cites W1988525857 @default.
- W2891163989 cites W1989970624 @default.
- W2891163989 cites W1990499122 @default.
- W2891163989 cites W1990606472 @default.
- W2891163989 cites W1990664273 @default.
- W2891163989 cites W1992127683 @default.
- W2891163989 cites W1997937385 @default.
- W2891163989 cites W2002986373 @default.
- W2891163989 cites W2008563981 @default.
- W2891163989 cites W2009497053 @default.
- W2891163989 cites W2010537412 @default.
- W2891163989 cites W2012486985 @default.
- W2891163989 cites W2014748872 @default.
- W2891163989 cites W2019408347 @default.
- W2891163989 cites W2019828482 @default.
- W2891163989 cites W2020674613 @default.
- W2891163989 cites W2020756748 @default.
- W2891163989 cites W2021229976 @default.
- W2891163989 cites W2021388888 @default.
- W2891163989 cites W2022762333 @default.
- W2891163989 cites W2024848067 @default.
- W2891163989 cites W2025427356 @default.
- W2891163989 cites W2032167680 @default.
- W2891163989 cites W2041672953 @default.
- W2891163989 cites W2043696829 @default.
- W2891163989 cites W2044114076 @default.
- W2891163989 cites W2045729780 @default.
- W2891163989 cites W2049047355 @default.
- W2891163989 cites W2049230954 @default.
- W2891163989 cites W2050205197 @default.
- W2891163989 cites W2064317460 @default.
- W2891163989 cites W2064394958 @default.
- W2891163989 cites W2065861544 @default.
- W2891163989 cites W2066731188 @default.
- W2891163989 cites W2069436844 @default.
- W2891163989 cites W2070739037 @default.
- W2891163989 cites W2070854143 @default.
- W2891163989 cites W2074692187 @default.
- W2891163989 cites W2075165459 @default.
- W2891163989 cites W2075264528 @default.
- W2891163989 cites W2079037244 @default.
- W2891163989 cites W2079080809 @default.
- W2891163989 cites W2080107580 @default.
- W2891163989 cites W2082513242 @default.
- W2891163989 cites W2082610990 @default.
- W2891163989 cites W2084521532 @default.
- W2891163989 cites W2090085551 @default.
- W2891163989 cites W2090381064 @default.
- W2891163989 cites W2093187453 @default.
- W2891163989 cites W2094290879 @default.
- W2891163989 cites W2094945914 @default.
- W2891163989 cites W2096051275 @default.
- W2891163989 cites W2096528587 @default.
- W2891163989 cites W2100295977 @default.
- W2891163989 cites W2100396630 @default.
- W2891163989 cites W2100686094 @default.
- W2891163989 cites W2102914417 @default.
- W2891163989 cites W2103404052 @default.
- W2891163989 cites W2103868159 @default.
- W2891163989 cites W2104969843 @default.
- W2891163989 cites W2108804546 @default.