FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891172725> ?p ?o ?g. }

• W2891172725 abstract "e15690 Background: Carcinoid syndrome (CS) is associated with a significant symptom burden and deleterious impacts on quality of life. Patients may experience delays in CS diagnosis of 5 to 7 years from initial onset of symptoms, as symptoms may be mistaken for other diseases, such as irritable bowel syndrome or menopause. The current study attempts to detect factors predictive of CS prior to CS diagnosis among patients with GI NETs. Methods: Using a US administrative claims database (IMS PharMetrics) and a retrospective case-control study design, patients (≥18 years) who were newly diagnosed with GI NETs without CS (controls) were exactly matched to patients with CS (cases) based on NET diagnosis date (month and year) at a 3-to-1 ratio. For CS patients, the study index date was the first CS diagnosis date. Each control patient was assigned to have the same index month and year as the matched case patient. The most frequently observed conditions other than symptoms/diagnoses known to be associated with CS during the 1 year prior to the index date were assessed. These conditions were entered into a forward-stepwise logistic regression model to derive predictive factors. Similar methods were applied to another administrative claims database (Truven Health Analytics MarketScan) to validate these predictors. Results: In the development database 1,004 patients with GI NETs were identified, among whom 251 (25%) had CS and 753 (75%) were controls. In both databases, three factors prior to CS diagnosis were found consistently associated with higher risks for CS, including liver disorder [odds ratio (95% CI): 3.38 (2.07 - 5.51)], enlargement of lymph nodes [2.13 (1.10 - 4.11)], and abdominal mass [3.79 (1.87 - 7.69)]. Conclusions: By assessing patients with GI NET from two independent US claim databases, this study suggested that patients diagnosed with CS were 2-3 times more likely to be diagnosed with liver disorder, enlargement of lymph nodes, or abdominal mass, than those without CS during the one year prior to CS diagnosis. Future studies using patients’ medical charts are warranted to validate and interpret the findings. These findings, when validated, may aid physicians to diagnose CS patients earlier." @default.
• W2891172725 created "2018-09-27" @default.
• W2891172725 creator A5008374258 @default.
• W2891172725 creator A5010044319 @default.
• W2891172725 creator A5017807808 @default.
• W2891172725 creator A5038383749 @default.
• W2891172725 creator A5078517105 @default.
• W2891172725 date "2017-05-20" @default.
• W2891172725 modified "2023-09-22" @default.
• W2891172725 title "Predictive factors of carcinoid syndrome among patients with gastrointestinal neuroendocrine tumors (GI NETs)." @default.
• W2891172725 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15690" @default.
• W2891172725 hasPublicationYear "2017" @default.
• W2891172725 type Work @default.
• W2891172725 sameAs 2891172725 @default.
• W2891172725 citedByCount "0" @default.
• W2891172725 crossrefType "journal-article" @default.
• W2891172725 hasAuthorship W2891172725A5008374258 @default.
• W2891172725 hasAuthorship W2891172725A5010044319 @default.
• W2891172725 hasAuthorship W2891172725A5017807808 @default.
• W2891172725 hasAuthorship W2891172725A5038383749 @default.
• W2891172725 hasAuthorship W2891172725A5078517105 @default.
• W2891172725 hasConcept C126322002 @default.
• W2891172725 hasConcept C143998085 @default.
• W2891172725 hasConcept C159110408 @default.
• W2891172725 hasConcept C2778506435 @default.
• W2891172725 hasConcept C2779066768 @default.
• W2891172725 hasConcept C2779951463 @default.
• W2891172725 hasConcept C2781151469 @default.
• W2891172725 hasConcept C71924100 @default.
• W2891172725 hasConcept C90924648 @default.
• W2891172725 hasConceptScore W2891172725C126322002 @default.
• W2891172725 hasConceptScore W2891172725C143998085 @default.
• W2891172725 hasConceptScore W2891172725C159110408 @default.
• W2891172725 hasConceptScore W2891172725C2778506435 @default.
• W2891172725 hasConceptScore W2891172725C2779066768 @default.
• W2891172725 hasConceptScore W2891172725C2779951463 @default.
• W2891172725 hasConceptScore W2891172725C2781151469 @default.
• W2891172725 hasConceptScore W2891172725C71924100 @default.
• W2891172725 hasConceptScore W2891172725C90924648 @default.
• W2891172725 hasLocation W28911727251 @default.
• W2891172725 hasOpenAccess W2891172725 @default.
• W2891172725 hasPrimaryLocation W28911727251 @default.
• W2891172725 hasRelatedWork W1968010660 @default.
• W2891172725 hasRelatedWork W2087059859 @default.
• W2891172725 hasRelatedWork W2128989652 @default.
• W2891172725 hasRelatedWork W2167203564 @default.
• W2891172725 hasRelatedWork W2559102023 @default.
• W2891172725 hasRelatedWork W2590625439 @default.
• W2891172725 hasRelatedWork W2600143366 @default.
• W2891172725 hasRelatedWork W2625594115 @default.
• W2891172725 hasRelatedWork W2791839429 @default.
• W2891172725 hasRelatedWork W2794497234 @default.
• W2891172725 hasRelatedWork W2885883408 @default.
• W2891172725 hasRelatedWork W2889737419 @default.
• W2891172725 hasRelatedWork W2905469019 @default.
• W2891172725 hasRelatedWork W2944515366 @default.
• W2891172725 hasRelatedWork W2955173620 @default.
• W2891172725 hasRelatedWork W2969839601 @default.
• W2891172725 hasRelatedWork W2985780809 @default.
• W2891172725 hasRelatedWork W3112976344 @default.
• W2891172725 hasRelatedWork W3160915265 @default.
• W2891172725 hasRelatedWork W350199319 @default.
• W2891172725 isParatext "false" @default.
• W2891172725 isRetracted "false" @default.
• W2891172725 magId "2891172725" @default.
• W2891172725 workType "article" @default.