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• W2891177761 abstract "Both Disrupted-In-Schizophrenia-1 (DISC1) and dopamine receptors D2R have significant contributions to the pathogenesis of schizophrenia. Our previous study demonstrated that DISC1 binds to D2R and such protein-protein interaction is enhanced in patients with schizophrenia and Disc1-L100P mouse model of schizophrenia (Su et al., 2014). By uncoupling DISC1xD2R interaction (TAT-D2pep), the synthesized TAT-peptide elicited antipsychotic-like effects in pharmacological and genetic animal models, without motor side effects as tardive dyskinesia commonly seen with typical antipsychotic drugs (APD), indicating that the potential of TAT-D2pep of becoming a new APD. Therefore, in the current study, we further explored the APD-associated capacities of TAT-D2pep. We found that TAT-D2pep corrected the disrupted latent inhibition, as a hallmark of schizophrenia associated endophenotype, in Disc1-L100P mutant mice - a genetic model of schizophrenia, supporting further APD’ capacity of TAT-D2pep. Moreover, we found that TAT-D2pep elicited nootropic effects in C57BL/6NCrl inbred mice, suggesting that TAT-D2pep acts as a cognitive enhancer, a desirable feature of APDs of the new generation. Namely, TAT-D2pep improved working memory in T-maze, and cognitive flexibility assessed by the latent inhibition paradigm, in C57BL/6N mice. Next, we assessed the impact of TAT-D2pep on hippocampal long-term plasticity (LTP) under basal conditions and upon stimulation of D2 receptors using quinpirole. We found comparable effects of TAT-D2pep and its control TAT-D2pep-scrambled peptide (TAT-D2pep-sc) under basal conditions. However, under stimulation of D2R by quinpirole, LTP was enhanced in hippocampal slices incubated with TAT-D2pep, supporting the notion that TAT-D2pep acts in a dopamine-dependent manner and acts as synaptic enhancer. Overall, our experiments demonstrated implication of DISC1xD2R protein-protein interactions into mechanisms of cognitive and synaptic plasticity, which help to further understand molecular-cellular mechanisms of APD of the next generation." @default.
• W2891177761 created "2018-09-27" @default.
• W2891177761 creator A5010396892 @default.
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• W2891177761 date "2018-09-07" @default.
• W2891177761 modified "2023-10-14" @default.
• W2891177761 title "Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors" @default.
• W2891177761 cites W132119412 @default.
• W2891177761 cites W1481546376 @default.
• W2891177761 cites W1925492557 @default.
• W2891177761 cites W1930926196 @default.
• W2891177761 cites W1963593709 @default.
• W2891177761 cites W1968072841 @default.
• W2891177761 cites W1969197988 @default.
• W2891177761 cites W1970040173 @default.
• W2891177761 cites W1970285386 @default.
• W2891177761 cites W1971676848 @default.
• W2891177761 cites W1971964419 @default.
• W2891177761 cites W1972196645 @default.
• W2891177761 cites W1972295386 @default.
• W2891177761 cites W1977490836 @default.
• W2891177761 cites W1981983103 @default.
• W2891177761 cites W1982543486 @default.
• W2891177761 cites W1985431011 @default.
• W2891177761 cites W1993560189 @default.
• W2891177761 cites W1994374993 @default.
• W2891177761 cites W1995959193 @default.
• W2891177761 cites W1999848070 @default.
• W2891177761 cites W2004723866 @default.
• W2891177761 cites W2006749296 @default.
• W2891177761 cites W2009006606 @default.
• W2891177761 cites W2009999409 @default.
• W2891177761 cites W2018385636 @default.
• W2891177761 cites W2019569575 @default.
• W2891177761 cites W2022725791 @default.
• W2891177761 cites W2023806007 @default.
• W2891177761 cites W2030059527 @default.
• W2891177761 cites W2034020626 @default.
• W2891177761 cites W2034091951 @default.
• W2891177761 cites W2035252993 @default.
• W2891177761 cites W2038372923 @default.
• W2891177761 cites W2043937142 @default.
• W2891177761 cites W2048479922 @default.
• W2891177761 cites W2050066016 @default.
• W2891177761 cites W2051503211 @default.
• W2891177761 cites W2056491890 @default.
• W2891177761 cites W2068288948 @default.
• W2891177761 cites W2075578206 @default.
• W2891177761 cites W2076747821 @default.
• W2891177761 cites W2081966018 @default.
• W2891177761 cites W2087782827 @default.
• W2891177761 cites W2090979638 @default.
• W2891177761 cites W2092416470 @default.
• W2891177761 cites W2093684789 @default.
• W2891177761 cites W2094970290 @default.
• W2891177761 cites W2096891080 @default.
• W2891177761 cites W2097026419 @default.
• W2891177761 cites W2097260594 @default.
• W2891177761 cites W2105012896 @default.
• W2891177761 cites W2119856466 @default.
• W2891177761 cites W2120071240 @default.
• W2891177761 cites W2123713110 @default.
• W2891177761 cites W2126168108 @default.
• W2891177761 cites W2126582286 @default.
• W2891177761 cites W2147137091 @default.
• W2891177761 cites W2151331628 @default.
• W2891177761 cites W2152770536 @default.
• W2891177761 cites W2158321076 @default.
• W2891177761 cites W2159404136 @default.
• W2891177761 cites W2160004904 @default.
• W2891177761 cites W2160964316 @default.
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• W2891177761 cites W2166306682 @default.
• W2891177761 cites W2170461909 @default.
• W2891177761 cites W2232050196 @default.
• W2891177761 cites W2378219007 @default.
• W2891177761 cites W2587167145 @default.
• W2891177761 cites W4230685253 @default.
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• W2891177761 doi "https://doi.org/10.3389/fnsyn.2018.00031" @default.
• W2891177761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6137395" @default.
• W2891177761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245624" @default.
• W2891177761 hasPublicationYear "2018" @default.
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