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- W2891183577 abstract "Transient receptor potential (TRP) channels are polymodally regulated ion channels. TRPV4 (vanilloid 4) is sensitized by PIP2 and desensitized by Syndapin3/PACSIN3, which bind to the structurally uncharacterized TRPV4 N terminus. We determined the nuclear magnetic resonance structure of the Syndapin3/PACSIN3 SH3 domain in complex with the TRPV4 N-terminal proline-rich region (PRR), which binds as a class I polyproline II (PPII) helix. This PPII conformation is broken by a conserved proline in a cis conformation. Beyond the PPII, we find that the proximal TRPV4 N terminus is unstructured, a feature conserved across species thus explaining the difficulties in resolving it in previous structural studies. Syndapin/PACSIN SH3 domain binding leads to rigidification of both the PRR and the adjacent PIP2 binding site. We determined the affinities of the TRPV4 N terminus for PACSIN1, 2, and 3 SH3 domains and PIP2 and deduce a hierarchical interaction network where Syndapin/PACSIN binding influences the PIP2 binding site but not vice versa." @default.
- W2891183577 created "2018-09-27" @default.
- W2891183577 creator A5013925789 @default.
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- W2891183577 date "2018-12-01" @default.
- W2891183577 modified "2023-10-11" @default.
- W2891183577 title "Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2" @default.
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- W2891183577 doi "https://doi.org/10.1016/j.str.2018.08.002" @default.
- W2891183577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6281781" @default.
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