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- W2891184420 abstract "Human cells have to deal with the constant production of reactive oxygen species (ROS). Although ROS overproduction might be harmful to cell biology, there are plenty of data showing that moderate levels of ROS control gene expression by maintaining redox signaling. Osteoarthritis (OA) is the most common joint disorder with a multi-factorial etiology including overproduction of ROS. ROS overproduction in OA modifies intracellular signaling, chondrocyte life cycle, metabolism of cartilage matrix and contributes to synovial inflammation and dysfunction of the subchondral bone. In arthritic tissues, the NF-κB signaling pathway can be activated by pro-inflammatory cytokines, mechanical stress, and extracellular matrix degradation products. This activation results in regulation of expression of many cytokines, inflammatory mediators, transcription factors, and several matrix-degrading enzymes. Overall, NF-κB signaling affects cartilage matrix remodeling, chondrocyte apoptosis, synovial inflammation, and has indirect stimulatory effects on downstream regulators of terminal chondrocyte differentiation. Interaction between redox signaling and NF-κB transcription factors seems to play a distinctive role in OA pathogenesis." @default.
- W2891184420 created "2018-09-27" @default.
- W2891184420 creator A5002854875 @default.
- W2891184420 creator A5049588656 @default.
- W2891184420 creator A5077783091 @default.
- W2891184420 date "2019-02-01" @default.
- W2891184420 modified "2023-10-09" @default.
- W2891184420 title "Redox and NF-κB signaling in osteoarthritis" @default.
- W2891184420 cites W1059897138 @default.
- W2891184420 cites W1508450059 @default.
- W2891184420 cites W1568529372 @default.
- W2891184420 cites W1812173421 @default.
- W2891184420 cites W1855842058 @default.
- W2891184420 cites W1899997617 @default.
- W2891184420 cites W1949785606 @default.
- W2891184420 cites W1962678949 @default.
- W2891184420 cites W1965671005 @default.
- W2891184420 cites W1966522800 @default.
- W2891184420 cites W1966527137 @default.
- W2891184420 cites W1967291007 @default.
- W2891184420 cites W1968095645 @default.
- W2891184420 cites W1969088009 @default.
- W2891184420 cites W1970370575 @default.
- W2891184420 cites W1971918460 @default.
- W2891184420 cites W1972634148 @default.
- W2891184420 cites W1972707678 @default.
- W2891184420 cites W1973633280 @default.
- W2891184420 cites W1974133503 @default.
- W2891184420 cites W1974834837 @default.
- W2891184420 cites W1976087136 @default.
- W2891184420 cites W1976164614 @default.
- W2891184420 cites W1983308621 @default.
- W2891184420 cites W1983937216 @default.
- W2891184420 cites W1985162545 @default.
- W2891184420 cites W1985406857 @default.
- W2891184420 cites W1985811862 @default.
- W2891184420 cites W1986542510 @default.
- W2891184420 cites W1986804691 @default.
- W2891184420 cites W1987880652 @default.
- W2891184420 cites W1988664606 @default.
- W2891184420 cites W1989067276 @default.
- W2891184420 cites W1989957948 @default.
- W2891184420 cites W1993808418 @default.
- W2891184420 cites W1997081407 @default.
- W2891184420 cites W1997323725 @default.
- W2891184420 cites W1998549225 @default.
- W2891184420 cites W1999405426 @default.
- W2891184420 cites W2000287184 @default.
- W2891184420 cites W2000756519 @default.
- W2891184420 cites W2001150048 @default.
- W2891184420 cites W2001762931 @default.
- W2891184420 cites W2001803608 @default.
- W2891184420 cites W2002541599 @default.
- W2891184420 cites W2002611021 @default.
- W2891184420 cites W2002831974 @default.
- W2891184420 cites W2002966162 @default.
- W2891184420 cites W2004065216 @default.
- W2891184420 cites W2004426856 @default.
- W2891184420 cites W2005603138 @default.
- W2891184420 cites W2007096529 @default.
- W2891184420 cites W2007470352 @default.
- W2891184420 cites W2009569724 @default.
- W2891184420 cites W2011867519 @default.
- W2891184420 cites W2012579765 @default.
- W2891184420 cites W2013462509 @default.
- W2891184420 cites W2016892864 @default.
- W2891184420 cites W2017473646 @default.
- W2891184420 cites W2017713162 @default.
- W2891184420 cites W2023250644 @default.
- W2891184420 cites W2024222798 @default.
- W2891184420 cites W2025034297 @default.
- W2891184420 cites W2025663995 @default.
- W2891184420 cites W2025974944 @default.
- W2891184420 cites W2026303159 @default.
- W2891184420 cites W2026505192 @default.
- W2891184420 cites W2027626913 @default.
- W2891184420 cites W2027884736 @default.
- W2891184420 cites W2030531215 @default.
- W2891184420 cites W2031592383 @default.
- W2891184420 cites W2032935444 @default.
- W2891184420 cites W2033088300 @default.
- W2891184420 cites W2033800625 @default.
- W2891184420 cites W2035304177 @default.
- W2891184420 cites W2035790314 @default.
- W2891184420 cites W2036760275 @default.
- W2891184420 cites W2038773696 @default.
- W2891184420 cites W2039002046 @default.
- W2891184420 cites W2039732133 @default.
- W2891184420 cites W2040179925 @default.
- W2891184420 cites W2041004167 @default.
- W2891184420 cites W2041831078 @default.
- W2891184420 cites W2044874861 @default.
- W2891184420 cites W2044924856 @default.
- W2891184420 cites W2045526608 @default.
- W2891184420 cites W2050486464 @default.
- W2891184420 cites W2051324748 @default.
- W2891184420 cites W2053108974 @default.
- W2891184420 cites W2053210011 @default.