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• W2891184788 abstract "Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8+ T-cell infiltration, suggesting that it may present similar challenges for immunotherapy as human GBM. Based on these key features for immune reactivity, SB28 may represent a treatment-resistant malignancy likely to mirror responses of many human tumors. We therefore propose that SB28 is a particularly suitable model for optimization of GBM immunotherapy." @default.
• W2891184788 created "2018-09-27" @default.
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• W2891184788 date "2018-09-05" @default.
• W2891184788 modified "2023-10-13" @default.
• W2891184788 title "Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models" @default.
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• W2891184788 doi "https://doi.org/10.1080/2162402x.2018.1501137" @default.
• W2891184788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279422" @default.
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