FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891186709> ?p ?o ?g. }

• W2891186709 endingPage "e0203268" @default.
• W2891186709 startingPage "e0203268" @default.
• W2891186709 abstract "Emerging evidence has shown that oocytes from diabetic ovaries exhibit delayed maturation, mitochondrial dysfunction and meiotic defects, which are related increased apoptosis. The main objective of the present study was to analyze the apoptosis pathways activated during follicular loss at multiple time points in a diabetic mouse model. Twenty BALB/c mice were used in this study, and diabetes mellitus was induced by streptozotocin injection. Three diabetic and two control animals were sacrificed on days 15, 20, 70 and 80 posttreatment. The ovaries were then removed; one was used for follicular counting, TUNEL, immunohistochemistry and immunofluorescence, while the other was used for Western blot analysis. The proteins studied were BAX, BCL2, t-BID, FAS, FASL, active caspase 8, active caspase 9 and active caspase 3. Follicular apoptosis decreased over time, with the highest values observed at 15 days posttreatment. Granulosa cells were positive for active caspase 3, which showed constant expression levels at all time points. FAS, FASL, t-BID and active caspase 8 showed strong cytoplasmic immunostaining in the oocytes and granulosa cells of the diabetic mice, with significant increases observed at 15, 20 and 70 days posttreatment. BAX expression was slightly higher in the diabetic mouse ovaries than in the control ovaries at 15, 20 and 70 days posttreatment, whereas the highest active caspase 9 expression was at observed 20 days posttreatment. Low BCL2 protein levels were detected in the diabetic mouse ovaries at all time points. This study describes for the first time the behavior of apoptosis-related proteins in the diabetic mouse ovary and shows not only that the FAS/FASL pathway contributes to follicular loss but also that antral follicles are the most affected." @default.
• W2891186709 created "2018-09-27" @default.
• W2891186709 creator A5013355210 @default.
• W2891186709 creator A5041348193 @default.
• W2891186709 creator A5045888426 @default.
• W2891186709 creator A5064063683 @default.
• W2891186709 creator A5064850172 @default.
• W2891186709 creator A5084835361 @default.
• W2891186709 creator A5090293550 @default.
• W2891186709 date "2018-09-07" @default.
• W2891186709 modified "2023-10-14" @default.
• W2891186709 title "Long-term apoptosis-related protein expression in the diabetic mouse ovary" @default.
• W2891186709 cites W1787488570 @default.
• W2891186709 cites W1950806555 @default.
• W2891186709 cites W1964948989 @default.
• W2891186709 cites W1977178308 @default.
• W2891186709 cites W1980836434 @default.
• W2891186709 cites W2008199204 @default.
• W2891186709 cites W2017278386 @default.
• W2891186709 cites W2019856376 @default.
• W2891186709 cites W2020267609 @default.
• W2891186709 cites W2041447827 @default.
• W2891186709 cites W2064568420 @default.
• W2891186709 cites W2078181183 @default.
• W2891186709 cites W2079476910 @default.
• W2891186709 cites W2084912135 @default.
• W2891186709 cites W2111974690 @default.
• W2891186709 cites W2114308118 @default.
• W2891186709 cites W2121974974 @default.
• W2891186709 cites W2122801878 @default.
• W2891186709 cites W2124974255 @default.
• W2891186709 cites W2126060958 @default.
• W2891186709 cites W2132778480 @default.
• W2891186709 cites W2138302361 @default.
• W2891186709 cites W2142237503 @default.
• W2891186709 cites W2148125367 @default.
• W2891186709 cites W2149745618 @default.
• W2891186709 cites W2152284014 @default.
• W2891186709 cites W2157803698 @default.
• W2891186709 cites W2161624529 @default.
• W2891186709 cites W2166406815 @default.
• W2891186709 cites W2221938935 @default.
• W2891186709 cites W2229285487 @default.
• W2891186709 cites W2320355255 @default.
• W2891186709 cites W2471605942 @default.
• W2891186709 cites W2479340653 @default.
• W2891186709 cites W2573884300 @default.
• W2891186709 doi "https://doi.org/10.1371/journal.pone.0203268" @default.
• W2891186709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128485" @default.
• W2891186709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192809" @default.
• W2891186709 hasPublicationYear "2018" @default.
• W2891186709 type Work @default.
• W2891186709 sameAs 2891186709 @default.
• W2891186709 citedByCount "8" @default.
• W2891186709 countsByYear W28911867092020 @default.
• W2891186709 countsByYear W28911867092022 @default.
• W2891186709 countsByYear W28911867092023 @default.
• W2891186709 crossrefType "journal-article" @default.
• W2891186709 hasAuthorship W2891186709A5013355210 @default.
• W2891186709 hasAuthorship W2891186709A5041348193 @default.
• W2891186709 hasAuthorship W2891186709A5045888426 @default.
• W2891186709 hasAuthorship W2891186709A5064063683 @default.
• W2891186709 hasAuthorship W2891186709A5064850172 @default.
• W2891186709 hasAuthorship W2891186709A5084835361 @default.
• W2891186709 hasAuthorship W2891186709A5090293550 @default.
• W2891186709 hasBestOaLocation W28911867091 @default.
• W2891186709 hasConcept C104317684 @default.
• W2891186709 hasConcept C12519072 @default.
• W2891186709 hasConcept C126322002 @default.
• W2891186709 hasConcept C134018914 @default.
• W2891186709 hasConcept C16685009 @default.
• W2891186709 hasConcept C187785154 @default.
• W2891186709 hasConcept C190283241 @default.
• W2891186709 hasConcept C196795494 @default.
• W2891186709 hasConcept C204232928 @default.
• W2891186709 hasConcept C2776415932 @default.
• W2891186709 hasConcept C2778324911 @default.
• W2891186709 hasConcept C2780362710 @default.
• W2891186709 hasConcept C31573885 @default.
• W2891186709 hasConcept C4224716 @default.
• W2891186709 hasConcept C55493867 @default.
• W2891186709 hasConcept C66008609 @default.
• W2891186709 hasConcept C71924100 @default.
• W2891186709 hasConcept C86803240 @default.
• W2891186709 hasConceptScore W2891186709C104317684 @default.
• W2891186709 hasConceptScore W2891186709C12519072 @default.
• W2891186709 hasConceptScore W2891186709C126322002 @default.
• W2891186709 hasConceptScore W2891186709C134018914 @default.
• W2891186709 hasConceptScore W2891186709C16685009 @default.
• W2891186709 hasConceptScore W2891186709C187785154 @default.
• W2891186709 hasConceptScore W2891186709C190283241 @default.
• W2891186709 hasConceptScore W2891186709C196795494 @default.
• W2891186709 hasConceptScore W2891186709C204232928 @default.
• W2891186709 hasConceptScore W2891186709C2776415932 @default.
• W2891186709 hasConceptScore W2891186709C2778324911 @default.
• W2891186709 hasConceptScore W2891186709C2780362710 @default.
• W2891186709 hasConceptScore W2891186709C31573885 @default.
• W2891186709 hasConceptScore W2891186709C4224716 @default.

• next