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- W2891201722 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology. Autotaxin (ATX) is a secreted lysophospholipase D, largely responsible for extracellular production of lysophosphatidic acid (LPA), a bioactive phospholipid. LPA has numerous effects in most cell types, signaling through at least 6 receptors (LPAR) exhibiting wide spread distribution and overlapping specificities. The ATX/LPA axis has been suggested as a therapeutic target in different chronic inflammatory and fibroproliferative disorders, including pulmonary fibrosis. In this report, we examined head-to-head the efficacy of a potent inhibitor of ATX (PF-8380), that has not been tested in pulmonary fibrosis models, and an antagonist of LPAR1 (AM095) in bleomycin (BLM)-induced pulmonary fibrosis. Both compounds abrogated the development of pulmonary fibrosis and prevented the distortion of lung architecture, exhibiting qualitative and quantitative differences in different manifestations of the modeled disease." @default.
- W2891201722 created "2018-09-27" @default.
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- W2891201722 date "2018-10-01" @default.
- W2891201722 modified "2023-10-16" @default.
- W2891201722 title "Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis" @default.
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- W2891201722 doi "https://doi.org/10.1016/j.pupt.2018.08.003" @default.
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