FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891208481> ?p ?o ?g. }

• W2891208481 endingPage "119" @default.
• W2891208481 startingPage "104" @default.
• W2891208481 abstract "Substance use disorders (SUD) often co-occur with other mental disorders such as major depression (MD). Our previous findings revealed sex-dependent changes in extracellular levels of glutamate (Glu) and glutamine (Gln) in the nucleus accumbens (NAc) in Long-Evans rats that were exposed to 21 days of chronic social defeat stress (CSDS), which models MD. The current study investigated the role of a Gln transporter called sodium-coupled neutral amino acid transporter subtype 1/2 (SNAT 1/2), phosphate-activated glutaminase (PAG), and astrocytic glutamate transporter-1 (GLT-1) on CSDS animals exposed to cocaine. Before cocaine exposure, CSDS males already showed decreased levels of SNAT 1/2 in the NAc and prefrontal cortex (PFC) compared to non-CSDS controls. The reduction in SNAT 1/2 levels was associated with an increase in Gln localization in the mitochondrial outer membrane in accumbal glutamatergic nerve terminals projecting from the PFC. CSDS females showed increased GLT-1 levels in the NAc and PFC compared to non-CSDS controls. Both acute and repeated cocaine exposure attenuated locomotor responses in CSDS males but increased those in CSDS females. Cocaine reduced SNAT 1/2 levels in the NAc but increased them in the PFC in CSDS males. Additionally, both PAG and GLT-1 levels were increased in the PFC in CSDS males. On the other hand, cocaine reduced SNAT 1/2 and GLT-1 levels in the NAc and PFC in CSDS females. Our results show that CSDS altered locomotor responses upon cocaine exposure in a sex-dependent manner that may be mediated by molecules associated with the Glu-Gln transfer." @default.
• W2891208481 created "2018-09-27" @default.
• W2891208481 creator A5003499766 @default.
• W2891208481 creator A5012002968 @default.
• W2891208481 creator A5012942553 @default.
• W2891208481 creator A5025413148 @default.
• W2891208481 creator A5032178707 @default.
• W2891208481 creator A5047178373 @default.
• W2891208481 creator A5060622348 @default.
• W2891208481 creator A5065908954 @default.
• W2891208481 creator A5066991245 @default.
• W2891208481 creator A5070213141 @default.
• W2891208481 date "2018-11-01" @default.
• W2891208481 modified "2023-10-16" @default.
• W2891208481 title "Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses" @default.
• W2891208481 cites W1485666412 @default.
• W2891208481 cites W1529416836 @default.
• W2891208481 cites W1967308562 @default.
• W2891208481 cites W1971395905 @default.
• W2891208481 cites W1974333168 @default.
• W2891208481 cites W1977850361 @default.
• W2891208481 cites W1981977925 @default.
• W2891208481 cites W1983353697 @default.
• W2891208481 cites W1984170477 @default.
• W2891208481 cites W1988304783 @default.
• W2891208481 cites W1992521533 @default.
• W2891208481 cites W1992548377 @default.
• W2891208481 cites W1993087404 @default.
• W2891208481 cites W1993860176 @default.
• W2891208481 cites W1994678934 @default.
• W2891208481 cites W1996361773 @default.
• W2891208481 cites W1996982207 @default.
• W2891208481 cites W1997221862 @default.
• W2891208481 cites W2004331086 @default.
• W2891208481 cites W2009243814 @default.
• W2891208481 cites W2016224955 @default.
• W2891208481 cites W2028892830 @default.
• W2891208481 cites W2029460899 @default.
• W2891208481 cites W2037544016 @default.
• W2891208481 cites W2039924079 @default.
• W2891208481 cites W2045379279 @default.
• W2891208481 cites W2047933315 @default.
• W2891208481 cites W2050434337 @default.
• W2891208481 cites W2051147967 @default.
• W2891208481 cites W2051972330 @default.
• W2891208481 cites W2053981588 @default.
• W2891208481 cites W2055397340 @default.
• W2891208481 cites W2056035374 @default.
• W2891208481 cites W2057881212 @default.
• W2891208481 cites W2059140543 @default.
• W2891208481 cites W2061534302 @default.
• W2891208481 cites W2061748321 @default.
• W2891208481 cites W2061934875 @default.
• W2891208481 cites W2065663423 @default.
• W2891208481 cites W2070472535 @default.
• W2891208481 cites W2072177208 @default.
• W2891208481 cites W2074661552 @default.
• W2891208481 cites W2079533376 @default.
• W2891208481 cites W2086126583 @default.
• W2891208481 cites W2090406819 @default.
• W2891208481 cites W2091845617 @default.
• W2891208481 cites W2094046759 @default.
• W2891208481 cites W2095220624 @default.
• W2891208481 cites W2102432541 @default.
• W2891208481 cites W2106862702 @default.
• W2891208481 cites W2119365587 @default.
• W2891208481 cites W2130617495 @default.
• W2891208481 cites W2143494072 @default.
• W2891208481 cites W2149797144 @default.
• W2891208481 cites W2152603717 @default.
• W2891208481 cites W2171126911 @default.
• W2891208481 cites W2231655582 @default.
• W2891208481 cites W2286968510 @default.
• W2891208481 cites W2296336023 @default.
• W2891208481 cites W2375106168 @default.
• W2891208481 cites W2560568756 @default.
• W2891208481 cites W2566992328 @default.
• W2891208481 cites W2588408561 @default.
• W2891208481 cites W2625626526 @default.
• W2891208481 cites W2740037054 @default.
• W2891208481 cites W2754805941 @default.
• W2891208481 cites W2761575587 @default.
• W2891208481 cites W2773957517 @default.
• W2891208481 cites W2774535172 @default.
• W2891208481 cites W4234810743 @default.
• W2891208481 doi "https://doi.org/10.1016/j.neuroscience.2018.09.009" @default.
• W2891208481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240589" @default.
• W2891208481 hasPublicationYear "2018" @default.
• W2891208481 type Work @default.
• W2891208481 sameAs 2891208481 @default.
• W2891208481 citedByCount "5" @default.
• W2891208481 countsByYear W28912084812020 @default.
• W2891208481 countsByYear W28912084812021 @default.
• W2891208481 countsByYear W28912084812023 @default.
• W2891208481 crossrefType "journal-article" @default.
• W2891208481 hasAuthorship W2891208481A5003499766 @default.
• W2891208481 hasAuthorship W2891208481A5012002968 @default.
• W2891208481 hasAuthorship W2891208481A5012942553 @default.

• next