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- W2891210194 abstract "In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but their role in obesity is unknown. We show that obesity in humans correlates with reduced expression of adipose tissue NLRP12. Similarly, Nlrp12-/- mice show increased weight gain, adipose deposition, blood glucose, NF-κB/MAPK activation, and M1-macrophage polarization. Additionally, NLRP12 is required to mitigate HFD-induced inflammasome activation. Co-housing with wild-type animals, antibiotic treatment, or germ-free condition was sufficient to restrain inflammation, obesity, and insulin tolerance in Nlrp12-/- mice, implicating the microbiota. HFD-fed Nlrp12-/- mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced Lachnospiraceae family and the associated enzymes required for short-chain fatty acid (SCFA) synthesis. Lachnospiraceae or SCFA administration attenuates obesity, inflammation, and dysbiosis. These findings reveal that Nlrp12 reduces HFD-induced obesity by maintaining beneficial microbiota." @default.
- W2891210194 created "2018-09-27" @default.
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- W2891210194 date "2018-09-01" @default.
- W2891210194 modified "2023-10-18" @default.
- W2891210194 title "The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis" @default.
- W2891210194 cites W1505106993 @default.
- W2891210194 cites W1514693175 @default.
- W2891210194 cites W1966332336 @default.
- W2891210194 cites W1969783259 @default.
- W2891210194 cites W1971415551 @default.
- W2891210194 cites W1974033843 @default.
- W2891210194 cites W1980539060 @default.
- W2891210194 cites W1989823340 @default.
- W2891210194 cites W1990590570 @default.
- W2891210194 cites W1990955264 @default.
- W2891210194 cites W1991309264 @default.
- W2891210194 cites W1993399595 @default.
- W2891210194 cites W1994366077 @default.
- W2891210194 cites W2004549986 @default.
- W2891210194 cites W2008869160 @default.
- W2891210194 cites W2009823411 @default.
- W2891210194 cites W2032661113 @default.
- W2891210194 cites W2032848182 @default.
- W2891210194 cites W2041081124 @default.
- W2891210194 cites W2041136224 @default.
- W2891210194 cites W2046208657 @default.
- W2891210194 cites W2051303794 @default.
- W2891210194 cites W2060185417 @default.
- W2891210194 cites W2063131576 @default.
- W2891210194 cites W2068734008 @default.
- W2891210194 cites W2073332363 @default.
- W2891210194 cites W2074026248 @default.
- W2891210194 cites W2076633494 @default.
- W2891210194 cites W2080998956 @default.
- W2891210194 cites W2083119809 @default.
- W2891210194 cites W2085284704 @default.
- W2891210194 cites W2088940658 @default.
- W2891210194 cites W2089246633 @default.
- W2891210194 cites W2090488505 @default.
- W2891210194 cites W2097515723 @default.
- W2891210194 cites W2098662346 @default.
- W2891210194 cites W2101328621 @default.
- W2891210194 cites W2104890139 @default.
- W2891210194 cites W2110936821 @default.
- W2891210194 cites W2113511371 @default.
- W2891210194 cites W2119316150 @default.
- W2891210194 cites W2121722333 @default.
- W2891210194 cites W2121828560 @default.
- W2891210194 cites W2122242590 @default.
- W2891210194 cites W2124848390 @default.
- W2891210194 cites W2127047718 @default.
- W2891210194 cites W2127865222 @default.
- W2891210194 cites W2136024338 @default.
- W2891210194 cites W2138673784 @default.
- W2891210194 cites W2140380746 @default.
- W2891210194 cites W2141189887 @default.
- W2891210194 cites W2144275312 @default.
- W2891210194 cites W2145697808 @default.
- W2891210194 cites W2150702412 @default.
- W2891210194 cites W2151172917 @default.
- W2891210194 cites W2163691580 @default.
- W2891210194 cites W2164386968 @default.
- W2891210194 cites W2164683872 @default.
- W2891210194 cites W2166449272 @default.
- W2891210194 cites W2169330513 @default.
- W2891210194 cites W2172334166 @default.
- W2891210194 cites W2293988845 @default.
- W2891210194 cites W2414763988 @default.
- W2891210194 cites W2534977774 @default.
- W2891210194 cites W2556702335 @default.
- W2891210194 cites W2559267012 @default.
- W2891210194 cites W2587727241 @default.
- W2891210194 cites W2596103622 @default.
- W2891210194 cites W2747882868 @default.
- W2891210194 cites W2786057901 @default.
- W2891210194 cites W41959363 @default.
- W2891210194 cites W4238497443 @default.
- W2891210194 cites W4247702375 @default.