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• W2891224975 startingPage "2549" @default.
• W2891224975 abstract "Small heat shock proteins (sHsps) are a ubiquitous family of molecular chaperones that rescue misfolded proteins from irreversible aggregation during cellular stress. Many such sHsps exist as large polydisperse species in solution, and a rapid dynamic subunit exchange between oligomeric and dissociated forms modulates their function under a variety of stress conditions. Here, we investigated the structural and functional properties of Hsp20 from thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. To provide a framework for investigating the structure-function relationship of Hsp20 and understanding its dynamic nature, we employed several biophysical and biochemical techniques. Our data suggested the existence of a ~24-mer of Hsp20 at room temperature (25 °C) and a higher oligomeric form at higher temperature (50 °C-70 °C) and lower pH (3.0-5.0). To our surprise, we identified a dimeric form of protein as the functional conformation in the presence of aggregating substrate proteins. The hydrophobic microenvironment mainly regulates the oligomeric plasticity of Hsp20, and it plays a key role in the protection of stress-induced protein aggregation. In Sulfolobus sp., Hsp20, despite being a non-secreted protein, has been reported to be present in secretory vesicles and it is still unclear whether it stabilizes substrate proteins or membrane lipids within the secreted vesicles. To address such an issue, we tested the ability of Hsp20 to interact with membrane lipids along with its ability to modulate membrane fluidity. Our data revealed that Hsp20 interacts with membrane lipids via a hydrophobic interaction and it lowers the propensity of in vitro phase transition of bacterial and archaeal lipids." @default.
• W2891224975 created "2018-09-27" @default.
• W2891224975 creator A5008589503 @default.
• W2891224975 creator A5020740373 @default.
• W2891224975 creator A5066553435 @default.
• W2891224975 creator A5089277669 @default.
• W2891224975 date "2018-12-01" @default.
• W2891224975 modified "2023-10-08" @default.
• W2891224975 title "The oligomeric plasticity of Hsp20 of Sulfolobus acidocaldarius protects environment-induced protein aggregation and membrane destabilization" @default.
• W2891224975 cites W1520225797 @default.
• W2891224975 cites W1790977108 @default.
• W2891224975 cites W1797775581 @default.
• W2891224975 cites W1868485901 @default.
• W2891224975 cites W1963994022 @default.
• W2891224975 cites W1964128878 @default.
• W2891224975 cites W1975200549 @default.
• W2891224975 cites W1975525201 @default.
• W2891224975 cites W1975773796 @default.
• W2891224975 cites W1975904015 @default.
• W2891224975 cites W1978029175 @default.
• W2891224975 cites W1983502971 @default.
• W2891224975 cites W1985530849 @default.
• W2891224975 cites W1988371819 @default.
• W2891224975 cites W1988598575 @default.
• W2891224975 cites W1989252221 @default.
• W2891224975 cites W1995466648 @default.
• W2891224975 cites W1996444327 @default.
• W2891224975 cites W2002602401 @default.
• W2891224975 cites W2004854794 @default.
• W2891224975 cites W2006910882 @default.
• W2891224975 cites W2007681784 @default.
• W2891224975 cites W2010335064 @default.
• W2891224975 cites W2011104464 @default.
• W2891224975 cites W2014300642 @default.
• W2891224975 cites W2014496529 @default.
• W2891224975 cites W2015585021 @default.
• W2891224975 cites W2018645739 @default.
• W2891224975 cites W2019866451 @default.
• W2891224975 cites W2020435673 @default.
• W2891224975 cites W2021821426 @default.
• W2891224975 cites W2024127505 @default.
• W2891224975 cites W2025493128 @default.
• W2891224975 cites W2039315146 @default.
• W2891224975 cites W2041718100 @default.
• W2891224975 cites W2043008590 @default.
• W2891224975 cites W2043587982 @default.
• W2891224975 cites W2045033562 @default.
• W2891224975 cites W2048141156 @default.
• W2891224975 cites W2054606479 @default.
• W2891224975 cites W2055085279 @default.
• W2891224975 cites W2058191960 @default.
• W2891224975 cites W2060716817 @default.
• W2891224975 cites W2068262186 @default.
• W2891224975 cites W2070670920 @default.
• W2891224975 cites W2070837164 @default.
• W2891224975 cites W2074842548 @default.
• W2891224975 cites W2075633711 @default.
• W2891224975 cites W2077758073 @default.
• W2891224975 cites W2079750084 @default.
• W2891224975 cites W2082768551 @default.
• W2891224975 cites W2083410704 @default.
• W2891224975 cites W2086068182 @default.
• W2891224975 cites W2087583350 @default.
• W2891224975 cites W2087689873 @default.
• W2891224975 cites W2088583078 @default.
• W2891224975 cites W2089192420 @default.
• W2891224975 cites W2090785584 @default.
• W2891224975 cites W2096878889 @default.
• W2891224975 cites W2097506306 @default.
• W2891224975 cites W2098555753 @default.
• W2891224975 cites W2101476524 @default.
• W2891224975 cites W2104775769 @default.
• W2891224975 cites W2105472242 @default.
• W2891224975 cites W2106630675 @default.
• W2891224975 cites W2124108854 @default.
• W2891224975 cites W2127033103 @default.
• W2891224975 cites W2129480430 @default.
• W2891224975 cites W2131102451 @default.
• W2891224975 cites W2134963281 @default.
• W2891224975 cites W2143227193 @default.
• W2891224975 cites W2144610636 @default.
• W2891224975 cites W2151487235 @default.
• W2891224975 cites W2154101227 @default.
• W2891224975 cites W2154940420 @default.
• W2891224975 cites W2170868227 @default.
• W2891224975 cites W2300552860 @default.
• W2891224975 cites W2315280707 @default.
• W2891224975 cites W2466861129 @default.
• W2891224975 cites W4237258603 @default.
• W2891224975 cites W4239833500 @default.
• W2891224975 doi "https://doi.org/10.1016/j.bbamem.2018.09.005" @default.
• W2891224975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30293966" @default.
• W2891224975 hasPublicationYear "2018" @default.
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