FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891229318> ?p ?o ?g. }

• W2891229318 endingPage "170" @default.
• W2891229318 startingPage "162" @default.
• W2891229318 abstract "Objective: Colon cancer occupies the third place in incidence worldwide; eating habits, in particular, consumption of hypercaloric diets, are relevant in its etiopathogenesis. On the other hand, foods can also modulate carcinogenesis: for example, proteins, which when hydrolyzed release peptides with biological activities, and legumes, especially, chickpea, represent a good source of hydrolysates. The objective of this work was to verify the inhibitory effect of chickpea hydrolyzed protein on azoxymethane (AOM)-induced carcinogenesis in mice fed a hypercaloric diet.Methods: We hydrolyzed chickpea protein by pepsin, pancreatin, and a combined pepsin–pancreatin system, to test its anticarcinogenic and hypercaloric activity in mice that had consumed a hypercaloric diet or a normal diet but were injected with azoxymethane (AOM).Results: A concentrate (70% proteins) was obtained from chickpea seeds (18.5% proteins), and extensive hydrolysates were obtained at 15 minutes, in all tested enzyme systems. The greatest activity was evidenced in the hydrolysates obtained with pepsin–pancreatin at 90 minutes. Animals that consumed the hypercaloric diet had a higher concentration of cholesterol and a higher atherogenic index, which were significantly reduced with the administration of chickpea protein hydrolysates with a dose-response effect (10, 20, or 30 mg/kg), whereas no effect was observed in animals that consumed the normal diet. In animals given AOM, aberrant crypts were observed, at a higher rate in animals that consumed the hypercaloric diet; with the consumption of hydrolysates by the animals that consumed either diet, the number of aberrant crypts was reduced with the 3 doses tested, and the effect was better in those animals fed the hypercaloric diet. The best effect in all tests was with 30 mg/kg body weight.Conclusion: The consumption of chickpea protein hydrolysates might confer a protective effect against colon carcinogenesis." @default.
• W2891229318 created "2018-09-27" @default.
• W2891229318 creator A5028633322 @default.
• W2891229318 creator A5037174470 @default.
• W2891229318 creator A5040411424 @default.
• W2891229318 creator A5044348627 @default.
• W2891229318 creator A5058188265 @default.
• W2891229318 creator A5065391542 @default.
• W2891229318 creator A5067479413 @default.
• W2891229318 creator A5068803276 @default.
• W2891229318 creator A5068932362 @default.
• W2891229318 date "2018-09-13" @default.
• W2891229318 modified "2023-10-18" @default.
• W2891229318 title "Protective Effect of Chickpea Protein Hydrolysates on Colon Carcinogenesis Associated With a Hypercaloric Diet" @default.
• W2891229318 cites W1908608955 @default.
• W2891229318 cites W1912844778 @default.
• W2891229318 cites W1963578873 @default.
• W2891229318 cites W1963847091 @default.
• W2891229318 cites W1964423289 @default.
• W2891229318 cites W1967654099 @default.
• W2891229318 cites W1968861261 @default.
• W2891229318 cites W1973780224 @default.
• W2891229318 cites W1975090615 @default.
• W2891229318 cites W1978624255 @default.
• W2891229318 cites W1980262181 @default.
• W2891229318 cites W1982723421 @default.
• W2891229318 cites W1984093520 @default.
• W2891229318 cites W1985333297 @default.
• W2891229318 cites W1985399572 @default.
• W2891229318 cites W1987271694 @default.
• W2891229318 cites W1993358805 @default.
• W2891229318 cites W2000015736 @default.
• W2891229318 cites W2006364391 @default.
• W2891229318 cites W2011016034 @default.
• W2891229318 cites W2012594735 @default.
• W2891229318 cites W2020313062 @default.
• W2891229318 cites W2022887940 @default.
• W2891229318 cites W2023400907 @default.
• W2891229318 cites W2026294309 @default.
• W2891229318 cites W2043415570 @default.
• W2891229318 cites W2052742862 @default.
• W2891229318 cites W2056964357 @default.
• W2891229318 cites W2060851254 @default.
• W2891229318 cites W2062918677 @default.
• W2891229318 cites W2069464232 @default.
• W2891229318 cites W2075811557 @default.
• W2891229318 cites W2092279282 @default.
• W2891229318 cites W2102558232 @default.
• W2891229318 cites W2109238063 @default.
• W2891229318 cites W2111458274 @default.
• W2891229318 cites W2117217248 @default.
• W2891229318 cites W2117692326 @default.
• W2891229318 cites W2120045074 @default.
• W2891229318 cites W2124895814 @default.
• W2891229318 cites W2132710304 @default.
• W2891229318 cites W2139776835 @default.
• W2891229318 cites W2142163565 @default.
• W2891229318 cites W2155052327 @default.
• W2891229318 cites W2271159090 @default.
• W2891229318 cites W2287965964 @default.
• W2891229318 cites W2415240970 @default.
• W2891229318 cites W2426916522 @default.
• W2891229318 cites W2593224892 @default.
• W2891229318 cites W2726101739 @default.
• W2891229318 cites W2730582036 @default.
• W2891229318 cites W2756850303 @default.
• W2891229318 doi "https://doi.org/10.1080/07315724.2018.1487809" @default.
• W2891229318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30211662" @default.
• W2891229318 hasPublicationYear "2018" @default.
• W2891229318 type Work @default.
• W2891229318 sameAs 2891229318 @default.
• W2891229318 citedByCount "27" @default.
• W2891229318 countsByYear W28912293182019 @default.
• W2891229318 countsByYear W28912293182020 @default.
• W2891229318 countsByYear W28912293182021 @default.
• W2891229318 countsByYear W28912293182022 @default.
• W2891229318 countsByYear W28912293182023 @default.
• W2891229318 crossrefType "journal-article" @default.
• W2891229318 hasAuthorship W2891229318A5028633322 @default.
• W2891229318 hasAuthorship W2891229318A5037174470 @default.
• W2891229318 hasAuthorship W2891229318A5040411424 @default.
• W2891229318 hasAuthorship W2891229318A5044348627 @default.
• W2891229318 hasAuthorship W2891229318A5058188265 @default.
• W2891229318 hasAuthorship W2891229318A5065391542 @default.
• W2891229318 hasAuthorship W2891229318A5067479413 @default.
• W2891229318 hasAuthorship W2891229318A5068803276 @default.
• W2891229318 hasAuthorship W2891229318A5068932362 @default.
• W2891229318 hasConcept C121608353 @default.
• W2891229318 hasConcept C126322002 @default.
• W2891229318 hasConcept C134018914 @default.
• W2891229318 hasConcept C16311235 @default.
• W2891229318 hasConcept C181199279 @default.
• W2891229318 hasConcept C2778452354 @default.
• W2891229318 hasConcept C28800991 @default.
• W2891229318 hasConcept C31903555 @default.
• W2891229318 hasConcept C55493867 @default.
• W2891229318 hasConcept C555283112 @default.
• W2891229318 hasConcept C71924100 @default.

• next