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• W2891231177 abstract "The peritoneal spread of ovarian cancer makes it a potential target for hyperthermic intraperitoneal chemotherapy (HIPEC). Intraperitoneal delivery exposes the tumor to concentrations of cytotoxic drugs much greater than with intravenous delivery, and in vitro studies have also shown that combining hyperthermia and platinum leads to an additive cytotoxic effect. Pharmacokinetic analyses have confirmed very high concentrations of cytotoxic drugs in the peritoneal cavity, with minimal systemic exposure and toxicity. The majority of historical data evaluating HIPEC in ovarian cancer are based on retrospective research, which included heterogeneous groups of patients and drugs used for HIPEC. Recent publications on the findings of prospective studies, including the first randomized trial in which the only difference in intervention was the addition of HIPEC with cisplatin to interval debulking surgery in stage III patients, have shown a benefit in favor of HIPEC. Yet, a recent prospective study from Korea did not find a benefit. Opponents of HIPEC have cited higher rates of complications with this approach, yet most of the serious adverse events observed are likely related to the surgery itself, and are comparable to the rates reported in studies evaluating cytoreductive surgery without HIPEC. Findings from a recent randomized controlled trial showed no delays in initiation or completion of postoperative chemotherapy in patients treated with HIPEC. A growing body of evidence is indicating that it might be time to seriously consider HIPEC as a complementary treatment at the time of cytoreductive surgery for patients with advanced-stage ovarian cancer in the setting of an experienced center. Yet, more research is needed to identify the population of patients who gain the most benefit from this therapy." @default.
• W2891231177 created "2018-09-27" @default.
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• W2891231177 date "2018-12-01" @default.
• W2891231177 modified "2023-10-17" @default.
• W2891231177 title "It's time to warm up to hyperthermic intraperitoneal chemotherapy for patients with ovarian cancer" @default.
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• W2891231177 cites W1871865048 @default.
• W2891231177 cites W1922469696 @default.
• W2891231177 cites W1952942151 @default.
• W2891231177 cites W1964023152 @default.
• W2891231177 cites W1971608129 @default.
• W2891231177 cites W1973703018 @default.
• W2891231177 cites W1973886552 @default.
• W2891231177 cites W1977537964 @default.
• W2891231177 cites W1992365152 @default.
• W2891231177 cites W2000124372 @default.
• W2891231177 cites W2009375859 @default.
• W2891231177 cites W2016888963 @default.
• W2891231177 cites W2026021862 @default.
• W2891231177 cites W2029957790 @default.
• W2891231177 cites W2034646290 @default.
• W2891231177 cites W2037678485 @default.
• W2891231177 cites W2038328856 @default.
• W2891231177 cites W2041430550 @default.
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• W2891231177 doi "https://doi.org/10.1016/j.ygyno.2018.09.007" @default.
• W2891231177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6684262" @default.
• W2891231177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249527" @default.
• W2891231177 hasPublicationYear "2018" @default.
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