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• W2891240143 abstract "ALK (D5F3) CDx: an immunohistochemistry assay to identify ALK-positive NSCLC patients Hironori Uruga,1 Mari Mino-Kenudson2 1Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan; 2Department of Pathology, Massachusetts General Hospital, Boston, MA, USA Abstract: Screening for anaplastic lymphoma kinase (ALK) rearrangements is a very important process in treatment decision making for advanced non-small-cell lung cancer (NSCLC). Although fluorescent in situ hybridization (FISH) is considered the universally accepted reference standard, it is associated with technical difficulties and high costs that have made global implementation of this assay challenging. Conversely, ALK immunohistochemistry has shown high sensitivity and specificity compared to FISH and other molecular assays and is more cost-effective. In fact, the ALK (D5F3) CDx immunohistochemistry assay was approved by the US Food and Drug Administration as a standalone test for ALK rearrangements in lung cancer in 2015. In this review, we will discuss the overview of ALK rearrangements in NSCLC, various testing methods for ALK rearrangements, and the details of immunohistochemistry for ALK, in particular one with the ALK antibody clone D5F3. Keywords: anaplastic lymphoma kinase gene ALK, D5F3 antibody, ALK (D5F3) CDx, non-small-cell lung cancer, adenocarcinoma" @default.
• W2891240143 created "2018-09-27" @default.
• W2891240143 creator A5056486246 @default.
• W2891240143 creator A5072389805 @default.
• W2891240143 date "2018-09-01" @default.
• W2891240143 modified "2023-10-18" @default.
• W2891240143 title "ALK (D5F3) CDx: an immunohistochemistry assay to identify ALK-positive NSCLC patients" @default.
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• W2891240143 doi "https://doi.org/10.2147/pgpm.s156672" @default.
• W2891240143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6147206" @default.
• W2891240143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271189" @default.
• W2891240143 hasPublicationYear "2018" @default.
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