FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891241246> ?p ?o ?g. }

• W2891241246 endingPage "3625" @default.
• W2891241246 startingPage "3620" @default.
• W2891241246 abstract "To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADPC) cell line LNCaP before and after the occurrence of androgen independence prostate cancer (AIPC) transition. In addition, we used the shRNA lentiviral vector to inhibit the PLD1 mRNA expression and observed its effect on LNCaP cell proliferation after AIPC transition by using MTS method. The results showed that the expression level of PLD1 mRNA was increased by 373-fold after AIPC transition (P<0.05); the PI3K/AKT signaling pathway-related gene expression was also elevated (P<0.05); the growth rate of LNCaP cells that had transited to androgen independence was reduced by about 30% when the PLD1 mRNA expression was inhibited by the shRNA lentivirus as compared with the negative control group (P<0.05). All these results suggest that PLD1 mRNA and the related PI3K/AKT signaling pathway may play an important role in AIPC. Down-regulating the expression of PLD1 mRNA could to some extent inhibit the proliferation rate of PCa cells after AIPC transition." @default.
• W2891241246 created "2018-09-27" @default.
• W2891241246 creator A5005170570 @default.
• W2891241246 creator A5012177911 @default.
• W2891241246 creator A5031415679 @default.
• W2891241246 creator A5036434427 @default.
• W2891241246 creator A5036479222 @default.
• W2891241246 creator A5049051557 @default.
• W2891241246 creator A5056723401 @default.
• W2891241246 creator A5073345002 @default.
• W2891241246 creator A5079375772 @default.
• W2891241246 date "2018-01-01" @default.
• W2891241246 modified "2023-10-18" @default.
• W2891241246 title "Inhibition of <i>Phospholipase D1</i> mRNA Expression Slows Down the Proliferation Rate of Prostate Cancer Cells That Have Transited to Androgen Independence" @default.
• W2891241246 cites W1489538543 @default.
• W2891241246 cites W1565459640 @default.
• W2891241246 cites W1973624256 @default.
• W2891241246 cites W1974406897 @default.
• W2891241246 cites W1979538859 @default.
• W2891241246 cites W1981279537 @default.
• W2891241246 cites W1984149271 @default.
• W2891241246 cites W1989689178 @default.
• W2891241246 cites W1996478052 @default.
• W2891241246 cites W2002853501 @default.
• W2891241246 cites W2040935952 @default.
• W2891241246 cites W2077907202 @default.
• W2891241246 cites W2107539666 @default.
• W2891241246 cites W2121257563 @default.
• W2891241246 cites W2129303232 @default.
• W2891241246 cites W2131949178 @default.
• W2891241246 cites W2137605045 @default.
• W2891241246 cites W2140777784 @default.
• W2891241246 cites W2156579546 @default.
• W2891241246 cites W2158734599 @default.
• W2891241246 cites W2467918789 @default.
• W2891241246 cites W2490404511 @default.
• W2891241246 cites W2519231905 @default.
• W2891241246 cites W2536255836 @default.
• W2891241246 cites W2536709210 @default.
• W2891241246 cites W2537333761 @default.
• W2891241246 cites W2735787139 @default.
• W2891241246 cites W2768734659 @default.
• W2891241246 doi "https://doi.org/10.7150/jca.26689" @default.
• W2891241246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171019" @default.
• W2891241246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310520" @default.
• W2891241246 hasPublicationYear "2018" @default.
• W2891241246 type Work @default.
• W2891241246 sameAs 2891241246 @default.
• W2891241246 citedByCount "4" @default.
• W2891241246 countsByYear W28912412462020 @default.
• W2891241246 countsByYear W28912412462021 @default.
• W2891241246 countsByYear W28912412462023 @default.
• W2891241246 crossrefType "journal-article" @default.
• W2891241246 hasAuthorship W2891241246A5005170570 @default.
• W2891241246 hasAuthorship W2891241246A5012177911 @default.
• W2891241246 hasAuthorship W2891241246A5031415679 @default.
• W2891241246 hasAuthorship W2891241246A5036434427 @default.
• W2891241246 hasAuthorship W2891241246A5036479222 @default.
• W2891241246 hasAuthorship W2891241246A5049051557 @default.
• W2891241246 hasAuthorship W2891241246A5056723401 @default.
• W2891241246 hasAuthorship W2891241246A5073345002 @default.
• W2891241246 hasAuthorship W2891241246A5079375772 @default.
• W2891241246 hasBestOaLocation W28912412461 @default.
• W2891241246 hasConcept C121608353 @default.
• W2891241246 hasConcept C173396325 @default.
• W2891241246 hasConcept C185592680 @default.
• W2891241246 hasConcept C190232843 @default.
• W2891241246 hasConcept C2779723316 @default.
• W2891241246 hasConcept C2780192828 @default.
• W2891241246 hasConcept C502942594 @default.
• W2891241246 hasConcept C54355233 @default.
• W2891241246 hasConcept C55493867 @default.
• W2891241246 hasConcept C6182249 @default.
• W2891241246 hasConcept C62112901 @default.
• W2891241246 hasConcept C62478195 @default.
• W2891241246 hasConcept C75217442 @default.
• W2891241246 hasConcept C81885089 @default.
• W2891241246 hasConcept C86554907 @default.
• W2891241246 hasConcept C86803240 @default.
• W2891241246 hasConcept C95444343 @default.
• W2891241246 hasConceptScore W2891241246C121608353 @default.
• W2891241246 hasConceptScore W2891241246C173396325 @default.
• W2891241246 hasConceptScore W2891241246C185592680 @default.
• W2891241246 hasConceptScore W2891241246C190232843 @default.
• W2891241246 hasConceptScore W2891241246C2779723316 @default.
• W2891241246 hasConceptScore W2891241246C2780192828 @default.
• W2891241246 hasConceptScore W2891241246C502942594 @default.
• W2891241246 hasConceptScore W2891241246C54355233 @default.
• W2891241246 hasConceptScore W2891241246C55493867 @default.
• W2891241246 hasConceptScore W2891241246C6182249 @default.
• W2891241246 hasConceptScore W2891241246C62112901 @default.
• W2891241246 hasConceptScore W2891241246C62478195 @default.
• W2891241246 hasConceptScore W2891241246C75217442 @default.
• W2891241246 hasConceptScore W2891241246C81885089 @default.
• W2891241246 hasConceptScore W2891241246C86554907 @default.
• W2891241246 hasConceptScore W2891241246C86803240 @default.
• W2891241246 hasConceptScore W2891241246C95444343 @default.
• W2891241246 hasIssue "19" @default.

• next